INTRODUCTION
REJUNEX OD CAPSULE is a combination of Alpha lipoic acid, Methylcobalamin, Folic acid and Pyridoxine which belongs to the group of medicines called Antioxidants and Vitamin B complex respectively. It is used to treat diabetic neuropathy (nerve damage occurring over time because of high sugar and fat levels in the blood due to diabetes).
Symptoms depend on the type of neuropathy, such as pain and numbness in your feet or problems with organ functions like those of your heart and bladder. It can also be used to treat general weakness and convalescence (recovering from an illness or injury).
REJUNEX OD CAPSULE is not recommended for use in children, so consult your doctor before taking it. Before taking REJUNEX OD CAPSULE, inform your doctor if you have any liver or kidney problems, cancer, a tumour, pernicious anaemia, are undergoing dialysis or if you have a coronary stent.
REJUNEX OD CAPSULE should not be used in pregnant women unless necessary. REJUNEX OD CAPSULE is not recommended for use by breastfeeding women. The most common side effects of REJUNEX OD CAPSULE are headache, low blood pressure, shortness of breath, a hot sensation or sweating. Contact your doctor if any of the symptoms get worse.
USES OF REJUNEX OD CAPSULE
Treats diabetic neuropathy
Treats general weakness
Treats convalescence
HOW REJUNEX OD CAPSULE WORKS
REJUNEX OD CAPSULE helps relieve nerve pain where methylcobalamin takes part in the production of myelin, a compound that covers and protects nerve fibres, thus restoring the damaged nerve cell and alpha-lipoic acid reduces oxidative stress, which is considered the main pathophysiology of diabetic neuropathy development. Folic acid (Vitamin B9) improves the functional recovery of nerves, the speed of nerve conduction and cell multiplication, while pyridoxine acts as a coenzyme in a wide range of metabolic functions affecting protein, carbohydrate and lipid utilization, like the breakdown of glycogen to glucose-1-phosphate and the synthesis of gamma-aminobutyric acid (GABA).
DIRECTIONS FOR USE
Take REJUNEX OD CAPSULE as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you based on your age, body weight and disease condition.
SIDE EFFECTS OF REJUNEX OD CAPSULE
COMMON
Headache
Decrease in blood pressure
Hot sensation
Sweating
RARE
Loss of appetite, nausea, vomiting, diarrhoea
Abdominal swelling, gas
Allergic reactions (redness, rash, itching, hives, breathlessness and anaphylactic reactions including shock)
Stop taking REJUNEX OD CAPSULE and contact your doctor immediately if you experience any of the following side effects:
Allergic reaction (rash, itching, breathlessness, swelling of face, lips, tongue or throat)
Decrease in blood sugar levels
HOW TO MANAGE SIDE EFFECTS
Headache:
Drink an ample amount of water and get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for a headache. If the headache does not improve, contact your doctor.
WARNING & PRECAUTIONS
PREGNANCY
REJUNEX OD CAPSULE is not recommended for use in pregnant women unless considered necessary. Consult your doctor before taking it.
BREASTFEEDING
REJUNEX OD CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel sleepy or dizzy after taking REJUNEX OD CAPSULE.
ALCOHOL
Avoid consumption of alcohol while taking REJUNEX OD CAPSULE because it may cause serious problems if you are thiamine deficient.
KIDNEY
REJUNEX OD CAPSULE should be taken with caution in patients with kidney problems or those undergoing haemodialysis due to kidney failure. Consult your doctor before taking it.
LIVER
REJUNEX OD CAPSULE should be taken with caution in patients with liver problems. Consult your doctor before taking it.
ALLERGY
Do not take REJUNEX OD CAPSULE if you are allergic to Alpha lipoic acid, Methylcobalamin, Folic acid, Pyridoxine or any of the other ingredients of this medicine.
HEART DISEASE
REJUNEX OD CAPSULE should be taken with caution in patients who have received a coronary stent (a tube inserted in the artery that leads to the heart, to prevent blockages). Consult your doctor before taking it.
OTHERS
REJUNEX OD CAPSULE is not recommended for use if you:
Have Leber’s disease (a genetic disease causing sudden vision loss)
Before taking REJUNEX OD CAPSULE, inform your doctor if you:
Have under or overactive thyroid
Have diabetes (high blood sugar)
Have polycythaemia vera (high numbers of red blood cells)
Have megaloblastic anaemia (abnormal red blood cells)
Have pernicious anaemia (prevention of vitamin B12 absorption) or could be having a vitamin B12 deficiency
Have cancer (unless you have anaemia due to folic acid deficiency)
Have a tumour
Use in Pediatrics:
REJUNEX OD CAPSULE is not recommended for use in children. Consult your doctor before taking it.
Use in Geriatrics:
Your doctor will prescribe the right dose of REJUNEX OD CAPSULE depending on your age, body weight and health condition. Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking REJUNEX OD CAPSULE, inform your doctor if you are taking any of the following medicines:
Medicines used to treat bacterial infections (Ex. neomycin, aminosalicylic acid, trimethoprim, sulphonamides, cotrimoxazole, chloramphenicol)
Medicines used to prevent stomach ulcers (Ex. famotidine, omeprazole)
Colchicine (used to treat gout)
Medicines used to prevent pregnancy (Ex. ethinylestradiol, norethindrone)
Medicines used to treat diabetes (Ex. insulin, metformin, glimepiride)
Medicines used to control epileptic fits (Ex. phenytoin, fosphenytoin, phenobarbital, primidone)
Medicines used to treat certain tumours (Ex. fluorouracil, methotrexate)
Medicines used to treat indigestion (Ex. edible clay, aluminium, magnesium)
Zinc (supplement important in pregnancy)
Sulfasalazine (used to treat inflammatory bowel diseases like ulcerative colitis and Crohn’s disease)
Cholestyramine (used to reduce blood cholesterol)
Levodopa (used to treat Parkinson’s disease)
Isoniazid (used to treat tuberculosis)
Penicillamine (used to treat arthritis)
Pyrimethamine (used to treat parasitic infections)
Amiodarone (used to treat irregular heartbeat)
Overdosage:
If you or anyone else accidentally took too much of REJUNEX OD CAPSULE, contact your doctor immediately.
SYNOPSIS
Drug : Alpha Lipoic Acid, Methylcobalamin, Folic Acid, Pyridoxine
Pharmacological Category : Antioxidants, Vitamins
Therapeutic Indication : Diabetic neuropathy, General weakness, Convalescence
Dosage Forms : Tablet, Capsule, Soft gel Capsule
MORE INFORMATION
Keep REJUNEX OD CAPSULE out of reach from children
Store below 25°C
FAQs ABOUT REJUNEX OD CAPSULE
Q: Can REJUNEX OD CAPSULE cause sunburn?
A: Taking REJUNEX OD CAPSULE along with amiodarone (a medicine used to treat irregular heartbeat) might increase the chances of sunburn, blistering or rashes on the skin exposed to sunlight. Wear sunblock, a screen and protective clothing when you are out in the sun, without fail.
Q: Can REJUNEX OD CAPSULE be given to children?
A: No, REJUNEX OD CAPSULE is intended for adults and should not be used by children. Your doctor will select a suitable alternative treatment for your child.
Q: Can I take REJUNEX OD CAPSULE if I have received a coronary stent?
A: No. Avoid using REJUNEX OD CAPSULE after receiving a coronary stent (a tube inserted in the artery that leads to the heart to prevent blockages), as it may increase the risk of blood vessel narrowing. Consult your doctor for further doubts.
Q: What if I forget to take a dose of REJUNEX OD CAPSULE?
A: If you forget to take a dose of REJUNEX OD CAPSULE, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take the medicine twice to make up for the forgotten dose.
Q: Can I take REJUNEX OD CAPSULE if I have any eye problems?
A: Do not take REJUNEX OD CAPSULE if you have Leber’s disease (a genetic disease-causing sudden vision loss), as it can seriously harm the optic nerve, which might cause blindness. Consult your doctor before taking this medicine if you have any other eye problems.
Q: Can REJUNEX OD CAPSULE be stopped?
A: Continue taking REJUNEX OD CAPSULE until your doctor tells you to stop, unless you experience any unwanted effects, a worsening of your condition or any new symptoms. Contact your doctor in such a case.
Q: Can I consume alcohol during treatment with REJUNEX OD CAPSULE?
A: Avoid consuming alcohol with REJUNEX OD CAPSULE treatment as it can lower the amount of thiamine (vitamin B1) in the body. Taking this medicine when there is a thiamine deficiency might cause serious health problems. Consult your doctor for further doubts.
Q: How should REJUNEX OD CAPSULE be taken? Can it be crushed?
A: No. Do not break, crush or chew REJUNEX OD CAPSULE. Take it as advised by your physician. Swallow it with a glass of water. Your doctor will determine the correct dose and duration for you based on your age, body weight and disease condition.
REFERENCES
1. KD Tripathi. Drugs Affecting Blood and Blood Formation. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 608.
2. Kang WB, Chen YJ, Lu DY, Yan JZ. Folic acid contributes to peripheral nerve injury repair by promoting Schwann cell proliferation, migration and secretion of nerve growth factor. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. January 2019. [Accessed on 1st August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263007/
3. Serhiyenko V, Serhiyenko L, Suslik G, et al. Alpha-lipoic acid: mechanisms of action and beneficial effects in the prevention and treatment of diabetic complications. MOJ Public Health. MedCrave. July 2018. [Accessed on 1st August 2022] https://medcraveonline.com/MOJPH/alpha-lipoic-acid-mechanisms-of-action-and-beneficial-effects-in-the-prevention-and-treatment-of-diabetic-complications.html
4. Duta Wacana Christian University. The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in December 2020] [Accessed on 1st August 2022] https://clinicaltrials.gov/ct2/show/NCT04689971?term=folic+acid&cond=Diabetic+Neuropathies&draw=2&rank=2
5. Ordain Health Care Global Pvt. Ltd. Alpha Lipoic Acid + Methylcobalamin + Folic Acid + Pyridoxine. [Revised in July 2019] [Accessed on 1st August 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2845.pdf
6. Micro Labs Ltd. Alpha Lipoic Acid + Methylcobalamin + Folic Acid + Pyridoxine. [Accessed on 1st August 2022] https://www.microlabsltd.com/elibrary/node/1799
USEFUL DIAGNOSTIC TESTS
Nerve conduction testing
Electromyography
Net Qty
1 N
Item Weight
17.5 g
Ingredient
MECOBALAMIN(METHYLCOBALAMIN) 1500 MCG+ALPHA LIPOIC ACID 100 mg+Pyridoxine Hydrochloride(Vit B6) 3 MG+FOLIC ACID 1.5 mg
Hsn Code
30045034
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