INTRODUCTION
PROGUT S POWDER contains Saccharomyces boulardi which belongs to the group of medicines called Probiotics. PROGUT S POWDER is used to treat acute infectious diarrhoea in adults and children (aged below 18 years) which is also used to treat and prevent antibiotic associated colitis (inflammatory bowel disease) and diarrhoea in affected individuals.
PROGUT S POWDER is also used in addition to vancomycin/metronidazole (antibiotic) medicines to treat recurrent Clostridium difficile diseases (colon infection) and prevent tube-feeding associated diarrhoea. The medicine is also indicated for use to treat irritable bowel syndrome (intestinal disorder) in affected individuals.
PROGUT S POWDER is not recommended for use in patients allergic to Saccharomyces boulardii. It is also not recommended for use in patients with central venous catheter (long flexible tube inserted into the vein of neck, chest, arm, and/or groin), and in patients who are immunocompromised/hospitalised (due to serious illness, and/or altered/weakened immune system).
Before taking PROGUT S POWDER, inform you had undergone liver transplantation. PROGUT S POWDER is not recommended for use in pregnant and breastfeeding women.
PROGUT S POWDER should be used with caution in children and adolescents (aged below 18 years) and is advised to be used in elderly patients (aged 65 years and above) after consulting the doctor.
The most common side effects of taking PROGUT S POWDER are constipation, bloating, and/or faecal incontinence. Consult your doctor if any of these symptoms worsens.
USES OF PROGUT S POWDER
Treats acute infectious diarrhoea in adults and children (aged below 18 years)
Treats and prevent antibiotic associated colitis (inflammatory bowel disease) and diarrhoea
Treats recurrent Clostridium difficile diseases (colon infection) and prevents tube-feeding associated diarrhoea
Treats irritable bowel syndrome (intestinal disorder) in affected individuals
HOW PROGUT S POWDER WORKS
PROGUT S POWDER works by inhibiting protease enzyme (responsible for protein breakdown) which helps to prevent development of bacterial overgrowth, host cell adherence, and provides a protective effect to the normal healthy gut flora thus preventing inflammation of gut and reducing frequency of passing stool and tiredness in individuals affected with diarrhoea.
DIRECTIONS FOR USE
Always take PROGUT S POWDER as advised by your physician. Pour the contents of the sachet in a little amount of water/ sweetened drink or mix it with food. Avoid mixing it with very cold/hot liquids/food and consume the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
SIDE EFFECTS OF PROGUT S POWDER
COMMON
Constipation
Bloating
Faecal incontinence
RARE
Flatulence
Stop taking PROGUT S POWDER and contact your doctor if you experience any of the following side effects:
Deterioration of health after 2 days of treatment
Fever, vomiting
Presence of blood/mucus in stools
Signs of dehydration such as intense thirst, and/or dryness of tongue
HOW TO MANAGE SIDE EFFECTS
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (such as going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate treatments for constipation.
WARNING & PRECAUTIONS
PREGNANCY
PROGUT S POWDER is generally not recommended for use during pregnancy. Consult your doctor before taking the medicine.
BREASTFEEDING
PROGUT S POWDER should be used with caution in breastfeeding women. Consult your doctor before taking the medicine.
LIVER
PROGUT S POWDER should be used with caution in patients who had undergone hepatic transplant. Consult a doctor before taking PROGUT S POWDER.
ALLERGY
Do not take PROGUT S POWDER if you are allergic to Saccharomyces boulardii, and/or any other ingredients of this medicine.
OTHERS
PROGUT S POWDER is not recommended for use if you:
Have central venous catheter (long flexible tube inserted into the vein of neck, chest, arm, and/or groin to receive drugs, fluids or blood in emergency or long-term treatment)
Are immunocompromised/hospitalised (due to serious illness, and/or altered/weakened immune system)
Have fructose intolerance
Suffer from congenital galactosemia (inability to break down galactose sugar), glucose and galactose malabsorption syndrome, and/or lactose intolerance
Use in Pediatrics:
PROGUT S POWDER should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
PROGUT S POWDER should be used with caution in elderly patients (aged 65 and above). Consult your doctor before taking PROGUT S POWDER.
INTERACTIONS
A. Drug–Drug interactions:
Before taking PROGUT S POWDER, inform your doctor if your taking any of the following medicines:
Oral antifungal agents (medicines used to treat fungal infections) Ex. Ketoconazole, clotrimazole, amphotericin
B. Drug–Food interactions:
Avoid taking too hot/cold food items while taking PROGUT S POWDER since it may reduce the effect of medicine.
Overdosage:
If you or anyone else accidentally takes too much of PROGUT S POWDER, then consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
SYNOPSIS
Drug : Saccharomyces
Pharmacological Category : Probiotics
Therapeutic Indication : Acute infectious diarrhoea, Recurrent Clostridium difficile diseases, and irritable bowel syndrome,Prevents antibiotic associated colitis & diarrhoea, Tube-feeding associated diarrhoea
Dosage Forms : Capsule, Syrup, Powder, Sachet
MORE INFORMATION
Keep PROGUT S POWDER out of reach for children
Do not store PROGUT S POWDER above 25°C
FAQs ABOUT PROGUT S POWDER
Q. What is PROGUT S POWDER used for?
A. PROGUT S POWDER is used to treat acute infectious diarrhoea in adults and children (aged below 18 years) which is also used to treat and prevent antibiotic associated colitis (inflammatory bowel disease) and diarrhoea in affected individuals. It is also used in addition to vancomycin/metronidazole (antibiotic) medicines to treat recurrent Clostridium difficile diseases (colon infection) and prevent tube-feeding associated diarrhoea. The medicine is also indicated for use to treat irritable bowel syndrome (intestinal disorder) in affected individuals.
Q. What are the common side effects of taking PROGUT S POWDER ?
A. The most common side effects of taking PROGUT S POWDER are constipation, bloating, and/or faecal incontinence. Consult your doctor if any of these symptoms worsens.
Q. How PROGUT S POWDER should be taken?
A. Always take PROGUT S POWDER as advised by your physician. Pour the contents of the sachet in a little amount of water/ sweetened drink or mix it with food. Avoid mixing it with very cold/hot liquids/food and consume the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q. What happens if PROGUT S POWDER is taken more than its required dosage?
A. If you or anyone else accidentally takes too much of PROGUT S POWDER, then consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Q. How PROGUT S POWDER works?
A. PROGUT S POWDER works by inhibiting protease enzyme (responsible for protein breakdown) which helps to prevent development of bacterial overgrowth, host cell adherence, and provides a protective effect to the normal healthy gut flora thus preventing inflammation of gut and reducing frequency of passing stool and tiredness in individuals affected with diarrhoea.
REFERENCES
1. K.D Tripathi. Drugs for Constipation and Diarrhoea. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 683.
2. Karolina Kazmierczak-Siedlecka, Jakub Ruszkowski, Mateusz Fic, Marcin Folwarski, Wojciech Makarewicz. Saccharomyces boulardii CNCM I-745: A Non-bacterial Microorganism Used as Probiotic Agent in Supporting Treatment of Selected Diseases. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. May 2020. [Accessed on 6th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415030/
3. Ener Cagri Dinleyici, Ates Kara, Metehan Ozen, Yvan Vandenplas. Saccharomyces boulardii CNCM I-745 in different clinical conditions. NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. July 2014. [Accessed on 6th January 2023] https://pubmed.ncbi.nlm.nih.gov/24995675/
4. C. Pothoulakis. Review article: Anti-inflammatory mechanisms of action of Saccharomyces boulardii. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. July 2008. [Accessed on 6th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761627/
5. S J Lewis, L F Potts, R E Barry. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients. NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. March 1998. [Accessed on 6th January 2023] https://pubmed.ncbi.nlm.nih.gov/9570649/
6. BIOCODEX. Ghana Food and Drugs Authority. [Revised in January 2019] [Accessed on 6th January 2023] https://fdaghana.gov.gh/img/pils/Bioflor%20250mg%20sachet.pdf
USEFUL DIAGNOSTIC TESTS
Blood culture
Stool culture
PRODUCT DETAILS
Hsn Code
30049099
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