INTRODUCTION
NERVZ DPN TABLET is a combination of Duloxetine and Methylcobalamin which belongs to the group of medicines called Serotonin and Norepinephrine Reuptake Inhibitors (SNRI) and Vitamins. It is indicated for the treatment of neuropathic pain.
NERVZ DPN TABLET is not recommended for use in patients with liver or severe kidney disease. Contact your doctor before taking NERVZ DPN TABLET should be used with caution in patients with kidney disease. [GBNKKEYWORD] is generally not recommended for use in pregnancy unless necessary.
NERVZ DPN TABLET should not be used by breastfeeding women because it may pass through the breast milk.NERVZ DPN TABLET is generally not advised for use in children and adolescents under the age of 18 unless necessary.
NERVZ DPN TABLET should be used with caution in patients over the age of 65. Specific serious side effects include the risk of suicidal ideation or behaviour (suicidality) after taking NERVZ DPN TABLET. This medicine’s most common side effects are headache, feeling sleepy, nausea, dry mouth, etc. Contact your physician if any of the symptoms worsen.
USES OF NERVZ DPN TABLET
Treats neuropathic pain
HOW NERVZ DPN TABLET WORKS
NERVZ DPN TABLET helps treat neuropathic pain, whereas duloxetine increases serotonin and noradrenaline levels in the brain. These messengers inhibit the pain signals reaching the brain and methylcobalamin, which helps in the production of myelin, a substance that protects nerve fibres and rejuvenates damaged nerve cells, Together, relieves neuropathic pain.
DIRECTIONS FOR USE
Take this medicine as advised by your physician. Swallow this medicine as a whole with a glass of water and do not crush or chew the medicine.
SIDE EFFECTS OF NERVZ DPN TABLET
COMMON
Headache, feeling sleepy
Nausea, dry mouth
Constipation, diarrhoea, stomach pain, vomiting, heartburn or indigestion, flatulence
Lack of appetite
Trouble sleeping, feeling agitated
Decreased sexual drive
Failure to experience orgasm
Anxiety
Unusual dreams
Dizziness, sluggish, tremor, numbness, pricking or tingling of the skin
Blurring of eyes
Tinnitus
Feeling pressure on the heart
Increased blood pressure, flushing
Increased yawning
Increased sweating, (itchy) rash
Muscle pain or spasm
Painful urination, frequent urination
Problems getting an erection
Changes in ejaculation
Falls
Fatigue
Weight loss
UNCOMMON
Throat inflammation causing a hoarse voice
Suicidal thoughts, difficulty sleeping, grinding or clenching the teeth, feeling disorientated, lack of motivation
Sudden involuntary jerks or muscle twitches, the sensation of restlessness or an inability to sit or stand still, feeling nervous, difficulty in concentration, changes in sense of taste, difficulty in controlling movement ex. lack of coordination or involuntary muscle movements, restless legs syndrome and decreased sleep
Large pupils, problems with eyesight
Dizziness or spinning sensation (vertigo), ear pain
Heart palpitations
Fainting, dizziness, light-headedness or fainting on standing up, cold fingers and toes
Throat tightness, nose bleeds
Vomiting blood or black tarry stools (faeces), gastroenteritis, burping, difficulty in swallowing
Night sweats, hives, cold sweats, sensitivity to sunlight and bruises easily
Muscle tightness or twitching
Difficulty in urination
Abnormal vaginal bleeding
Abnormal periods such as heavy, painful, irregular or prolonged periods or light or missed periods,
Pain in the testicles or scrotum
Pain in the chest
Coldness, thirsty
Shivers, feeling hot
Abnormal gait
Weight gain
Increases in liver enzymes
Increase in potassium
Increase in creatine phosphokinase
Elevated sugar levels
Increased cholesterol in the blood
RARE
Decreased thyroid function causing tiredness or weight gain
Low sodium levels (hyponatremia), dehydration
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
Serotonin syndrome (feelings of great happiness, drowsiness, clumsiness, restlessness, feeling of being drunk, fever, sweating or rigid muscles)
Fits
Increased pressure in the eye (glaucoma)
Coughing, wheezing and shortness of breath, accompanied by a high fever
Mouth inflammation
Passing red-coloured stools
Bad breath, inflammation of the large intestine causing diarrhoea
Contraction of the jaw muscle
Change in urine smell
Symptoms of menopause
Abnormal breast milk production in men or women
Excessive vaginal bleeding after birth (postpartum haemorrhage)
Acne-like and blister rashes
Stop taking NERVZ DPN TABLET and contact your physician immediately if you experience any of the following side effects:
Allergic reaction such as itchy rash, swelling of the face, lips, tongue or throat causing difficulty in breathing
Symptoms of Stevens-Johnson syndrome such as serious illness with blisters on the skin, mouth, eyes and genitals
Symptoms of liver disease such as yellowish discolouration of the skin or whites of the eyes (jaundice), abdominal pain
Vomiting blood or black tarry stools
Mania (over-activity), hallucinations, aggression and anger
Suicidal behaviour or thoughts about suicide or dying
New or worsening depression
New or worsening anxiety
Feeling very agitated or restless
Panic attacks
Insomnia
New or worse irritability
Aggressiveness, being angry or violent
Acting on dangerous impulses
Other unusual changes in behaviour or mood
HOW TO MANAGE SIDE EFFECTS
Nausea, vomiting:
Take this medicine with meals or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.
Headache:
Rest and relax. Drink plenty of fluids, such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom does not improve.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices, to keep you hydrated. Take no medication on your own to treat diarrhoea. Contact your doctor if the symptom does not improve.
Stomach pain:
Try to rest and relax. Consume small meals regularly. Keep a heating pad on your stomach. Contact your doctor if the symptom does not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom does not improve.
Flatulence:
Eat smaller and more frequent meals. Eat and exercise regularly. Contact your doctor if the symptom does not improve.
Constipation:
Eat plenty of fibre-rich foods, such as fresh fruits, vegetables and cereals and drink water. Exercise regularly.
Skin rash:
Avoid hot showers because hot water can further irritate your skin. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturise your skin. Contact your doctor if the symptoms do not resolve.
WARNING & PRECAUTIONS
PREGNANCY
[GBNKKEYWORD] is generally not recommended for use in pregnancy unless considered necessary. Contact your doctor before taking it.
BREASTFEEDING
NERVZ DPN TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Contact your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizzy or sleepy after taking NERVZ DPN TABLET.
ALCOHOL
Avoid consumption of alcohol while taking NERVZ DPN TABLET as it may lead to unwanted effects.
KIDNEY
NERVZ DPN TABLET is not recommended for use in patients with severe kidney disease. Contact your doctor before taking it.
LIVER
NERVZ DPN TABLET is not recommended for use in patients with liver disease. Contact your doctor before taking it.
ALLERGY
Do not take NERVZ DPN TABLET if you are allergic to Duloxetine, Methylcobalamin or sucrose, lactose, some sugars or other ingredients of this medicine.
HEART DISEASE
NERVZ DPN TABLET should be used with caution in patients with heart diseases. Contact your doctor before taking it.
OTHERS
NERVZ DPN TABLET is not recommended for use if you have:
Uncontrolled blood pressure
Before taking NERVZ DPN TABLET, inform your doctor if you have:
Seizures
Mania
Major depressive disorder
Bipolar disorder
Depression or anxiety
Glaucoma
Leber’s disease
History of bleeding disorders
Low sodium levels
Low potassium levels
Urinary incontinence or retention
Orthostatic hypotension and syncope
Concomitant illness
Decreased gastric emptying
Diabetes
Pernicious anaemia
Iron or folic acid deficiency
Use in Paediatrics:
NERVZ DPN TABLET is generally not recommended for use in children and adolescents under 18 years of age unless necessary. Contact your doctor before taking it.
Use in Geriatrics:
NERVZ DPN TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Inform your physician if you are using:
Medicines used for depression like moclobemide, fluvoxamine, nortriptyline, amitriptyline, imipramine, desipramine, clomipramine, paroxetine, fluoxetine, venlafaxine
Benzodiazepines (medicines used for seizures, insomnia) Ex. diazepam
Tramadol, pethidine (medicines used for severe pain)
Antipsychotics like olanzapine and risperidone (medicines used to treat psychoses)
Phenobarbital (medicines used to treat seizures)
Antihistamines like chlorpheniramine (used for allergies)
Linezolid (medicines used to treat bacterial infections)
St John’s Wort (medicines used for depression)
Sumatriptan (medicines used for migraine)
Tryptophan (nutrient supplement)
Theophylline (medicines used to treat asthma)
Tolterodine (a medicine used for overactive bladder)
Flecainide, propafenone and metoprolol (medicines used to treat heart diseases)
Oral contraceptives (used for preventing pregnancy)
Steroids (medicines used to treat pain and inflammation) Ex. prednisone
Anticoagulants Ex. warfarin (medicines used to treat blood clots)
Antiplatelet agents like dipyridamole (medicines used to prevent blood cell clumping)
Aluminium- and magnesium-containing antacids (medicines used to treat heartburn or indigestion)
Cimetidine, famotidine (medicines used for stomach ulcers)
Ciprofloxacin or enoxacin (medicines used for bacterial infections)
Diuretics (medicines used to treat high blood pressure) Ex. Chlorothiazide
Neomycin, chloramphenicol (medicines used to treat bacterial infections)
Colchicine (medicines used to treat gout)
Metformin (medicines used to treat diabetes mellitus)
Omeprazole, lansoprazole (medicines used to treat stomach ulcers, indigestion)
Cholestyramine (medicines used to decrease high cholesterol levels)
Potassium chloride (medicines used to treat potassium correction)
Methyldopa (medicines used for hypertension)
Antimetabolites like fluorouracil (medicines used to treat cancer)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are somnolence, coma, serotonin syndrome (feelings of great happiness, drowsiness, clumsiness, restlessness, feeling of being drunk, fever, sweating or rigid muscles), seizures, syncope, tachycardia, hypotension, hypertension and vomiting.
SYNOPSIS
Drug : Duloxetine, Methylcobalamin
Pharmacological Category : Serotonin and Norepinephrine Reuptake Inhibitor and Vitamins
Therapeutic Indication : Neuropathic pain
Dosage Forms : Tablet
MORE INFORMATION
Keep out of reach from children
Store NERVZ DPN TABLET below 30°C
FAQs ABOUT NERVZ DPN TABLET
Q: How does NERVZ DPN TABLET function?
A: NERVZ DPN TABLET helps treat neuropathic pain, where duloxetine works by increasing the levels of serotonin and noradrenaline in the brain. These messengers inhibit the pain signals reaching the brain and methylcobalamin, which helps in the production of myelin, a substance that protects nerve fibres and rejuvenates damaged nerve cells, Together, they relieve neuropathic pain.
Q: Does NERVZ DPN TABLET cause suicidal thoughts?
A: Yes. NERVZ DPN TABLET causes suicidal thoughts. Stop taking NERVZ DPN TABLET and contact your doctor if you experience any unusual symptoms, like suicidal ideation or behaviour.
Q: Does NERVZ DPN TABLET cause weight gain?
A: Yes. NERVZ DPN TABLET may cause weight gain with long-term use. Contact your doctor before taking it.
Q: Does NERVZ DPN TABLET cause sleepiness?
A: Yes. NERVZ DPN TABLET may cause sleepiness. Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling sleepy. Do not consume alcohol, as it can aggravate your sleepiness. Contact your doctor if the symptom does not improve.
Q: What are the side effects of taking NERVZ DPN TABLET?
A: The most common side effects of this medicine are headache, feeling sleepy, nausea, dry mouth, etc. Contact your physician if any of the symptoms worsen.
REFERENCES
1. KD Tripathi. Antidepressant and Antianxiety drugs & Haematinics and Erythropoietin. Essentials of medical pharmacology. Seventh edition. 2013. Page- 462, 608.
2. Chetna Sharma, Inderpal Kaur, Harpreet Singh, Inderpal Singh Grover and Jatinder Singh. Uses of methylcobalamin plus duloxetine. Indian Journal of Pharmacology. September 2021. [Accessed on 14th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641739/
3. Jaberpreet S. Dhaliwal, Benjamin C. Spurling, Mohammed Molla. Mechanism of duloxetine. National Institute of Health. NLM. National Centre for Biotechnology Information. Pubmed.gov. May 2022. [Accessed on 14th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK549806/
4. Gupta JK, Qureshi Shaiba Sana. Uses of methylcobalamin. Austin Journal of Pharmacology and therapeutics. October 2015. [Accessed on 14th June 2022] https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v3-id1076.php#:~:text=Methylcobalamin%20helps%20in%20the%20synthesis,approved%20treatment%20for%20peripheral%20neuropathy
5. Eli Lilly and Company. U.S. Food & Drug Administration. [Revised in October 2010] [Accessed on 14th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022516lbl.pdf
6. Pharmathen International S.A. Health Products Regulatory Authority (HPRA). [Revised in February 2021] [Accessed on 14th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/7e72e981-379d-4e2b-989b-7e3ff3db9b91.pdf
7. Eli Lilly and Company Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 14th June 2022] https://www.medicines.org.uk/emc/files/pil.3880.pdf
8. Recipharm Limited. Electronic Medicines Compendium (EMC). [Revised in April 2019] [Accessed on 14th June 2022] https://www.medicines.org.uk/emc/files/pil.5716.pdf
9. Duloxetine. Torrent Pharmaceuticals Ltd. [Revised in July 2019] [Accessed on 14th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2895.pdf
Net Qty
1 N
Item Weight
17.5 g
Ingredient
DULOXETINE 60MG+METHYLCOBALAMIN 1500MCG
Hsn Code
30049099
Show more
Reviews
There are no reviews yet.