Natzold 5mg Infusion 100ml

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Natzold 5mg Infusion 100ml

 Zoledronic Acid 5 mg

NATZOLD contains Zoledronic Acid which belongs to the group of medicines called Bisphosphonates. NATZOLD is used in post-menopausal women and adult men to treat osteoporosis or osteoporosis caused by treatment with corticosteroids and Paget’s disease of the bone in adults.

Osteoporosis is a bone disease that develops when bone mineral density and bone mass decreases or when the quality or structure of the bone changes. It usually occurs in women after the menopause and also occurs in adult men. Paget’s disease of bone is a chronic bone disorder which disrupts the normal cycle of bone renewal, causing bones to become weakened and possibly deformed.

Along treatment with NATZOLD your doctor might ask you to make some lifestyle changes such as eating balanced diet rich in calcium and vitamin D. Prior to starting the treatment with NATZOLD your doctor might want you to take some diagnostic tests to understand the existing condition.

NATZOLD is not recommended for use in patients with severe kidney problems and hypocalcemia (low levels of calcium in the blood). NATZOLD is not recommended for use in pregnant and breastfeeding women. Consult your doctor before receiving NATZOLD.

NATZOLD is not recommended for use in children and adolescents (under 18 years of age) and should be used with caution in elderly patients. The most common side effects of receiving NATZOLD are headache, dizziness, vomiting, diarrhoea, fever, chills, pain in muscles, joints or bones and pain in back, arms or legs. Inform your doctor if any of the symptom worsens.

USES OF NATZOLD
Treats osteoporosis or corticosteroid-induced osteoporosis (in post-menopausal women and adult men)
Treats Paget’s disease of the bone (in adults)
HOW NATZOLD WORKS

NATZOLD works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bones and minimizes the risk of fractures.

DIRECTIONS FOR USE

NATZOLD will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of NATZOLD for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF NATZOLD
COMMON
Fever, chills
Pain in muscles, joints or bones
Headache, dizziness
Sickness, vomiting
Diarrhoea
Pain in back, arms or legs
Flu-like symptoms such as tiredness, fever, muscle pain
Lack of interest, weakness, feeling unwell
Pain
Swelling or pain at the infusion site
Low calcium levels in blood (signs include muscle spasms or numbness or tingling sensation)
UNCOMMON
Upper respiratory tract infections
Decreased red cell count (anaemia)
Loss of appetite, heartburn
Sleeplessness
Sleepiness associated with reduced alertness and awareness
Tingling sensation or numbness, flushing
Temporary loss of consciousness, trembling
Eye infection or irritation or inflammation with pain and redness
Spinning sensation (vertigo)
Increased blood pressure
Shortness of breath, cough
Abdominal pain, upset stomach, constipation
Dry mouth, thirst
Skin rash, itching, skin reddening
Excessive sweating
Stiffness in muscles, bones or joints
Shoulder or neck pain, muscle spasms
Pain in chest muscles and rib cage
Joint inflammation
Muscular weakness
Abnormal frequent urination
Extreme tiredness, swelling of hands, ankles or feet
Toothache
Taste disturbances
RARE
Low levels of phosphate in blood
Unusual fracture of thigh bone (symptoms such as pain, weakness or discomfort in thigh, hip or groin)

Consult your doctor if you experience any of the following side effects after receiving NATZOLD:

Irregular heart rhythm (atrial fibrillation)
Swelling, redness, pain and itching to the eyes or eye sensitivity to light
Osteonecrosis of the jaw (signs include any problems with your mouth or teeth such as loose teeth, pain or swelling, or non-healing of sores or discharge)
HOW TO MANAGE SIDE EFFECTS

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.

Vomiting:

Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.

Dizziness:

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Inform your doctor if the symptom gets worse.

Diarrhoea:

Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high fat or spicy foods. Inform your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. If this does not help, inform your doctor for receiving alternate treatment for constipation.

Abdominal pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, inform your doctor.

WARNING & PRECAUTIONS
PREGNANCY

NATZOLD is not recommended for use in pregnant women. Consult your doctor before receiving NATZOLD.

BREASTFEEDING

NATZOLD is not recommended for use in breastfeeding women. Consult your doctor before receiving NATZOLD.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizziness after receiving NATZOLD.

KIDNEY

NATZOLD is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with other kidney problems. Consult your doctor before receiving NATZOLD.

ALLERGY

Do not receive NATZOLD if you are allergic to Zoledronic Acid or other bisphosphonate (such as alendronate) or any of the other ingredients of this medicine.

OTHERS

NATZOLD is not recommended for use if you:

Have hypocalcaemia (low levels of calcium in the blood)

Before receiving NATZOLD inform your doctor if you:

Are unable to take daily calcium supplements
Have had some or all of the parathyroid glands in neck surgically removed
Have had intestinal sections removed
Have any problems with mouth or teeth such as poor dental health or gum disease
Have not received routine dental care or have not had dental check-up for long time
Are smoker (increase the risk of dental problems)
Are under dental treatment or due to undergo dental surgery (Ex. tooth extractions)
Have cancer

Use in paediatrics:

NATZOLD is not recommended for use in children and adolescents (under 18 years of age). Consult child’s doctor for advice.

 Use in geriatrics:

NATZOLD should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving NATZOLD.

INTERACTIONS

A. Drug – Drug Interactions:

Before receiving NATZOLD, inform your doctor if you are taking any of the following medicines:

Aminoglycosides such as gentamicin (used to treat severe bacterial infections)
Diuretics (water pills) such as chlorthalidone, indapamide (used to treat high blood pressure or oedema)
Other bisphosphonates such as alendronate (used to treat or prevent bone disorders)
Corticosteroids such as prednisolone or dexamethasone (used to treat inflammation)

Overdosage:

NATZOLD will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms after receiving NATZOLD.

SYNOPSIS
Drug :   Zoledronic Acid
Pharmacological Category :   Bisphosphonates
Therapeutic Indication :   Osteoporosis, Paget’s disease of the bone
Dosage Forms :   Injection, Infusion
MORE INFORMATION
Store at room temperature
FAQs ABOUT NATZOLD

How long should I receive NATZOLD?

NATZOLD should be received in the dose and duration as advised by your doctor. The medicine takes around 6 months to show its maximum benefits on bones. However, in some cases, the doctor may suggest NATZOLD for a longer duration. The exact duration will depend on the condition you are being treated for.

How is NATZOLD administered?

NATZOLD will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of NATZOLD for you depending upon your age, body weight and disease condition.

What are the lifestyle changes should I follow while receiving NATZOLD?

To get maximum benefit from this medicine, there are certain lifestyle changes that you must adhere to. Include some calcium or vitamin D rich foods for bone strength. Try to spend more time in sunlight to get natural vitamin D. Quit smoking and reduce alcohol consumption as they may harm your bones. You can take up an exercise regime such as walking and low-impact aerobics as they are good for your bones. Similarly, you can try strength-training exercises where you use your own body weight which in turn improve bone health.

Can NATZOLD cause constipation?

Yes, NATZOLD may cause constipation in some individuals. To manage this effect, try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. If this does not help, inform your doctor for receiving alternate treatment for constipation.

Is NATZOLD safe to use in pregnant or breast-feeding women?

NATZOLD is not recommended for use in pregnant and breast-feeding women. Consult your doctor before receiving NATZOLD if you are pregnant or planning to pregnant or breast-feeding.

REFERENCES

1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page – 4229-4231.

2. Ma Chao, Qin Hua, Zhou Yingfeng, Wan Guang, Shi Shufeng, Dong Yuzhen, Wang Wei, and Tan Haifeng. Study on the role of zoledronic acid in treatment of postmenopausal osteoporosis women. NIH: National Library of Medicine, National center of biotechnology Information, PMC Pubmed Central. December 2013 [Accessed on 7th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905367/

3. Margaret Seton and Stephen M Krane. Use of zoledronic acid in the treatment of Paget’s disease. NIH: National Library of Medicine, National center of biotechnology Information, PMC, Pubmed Central. October 2007 [Accessed on 7th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376069/

4. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 7th June 2022] https://www.medicines.org.uk/emc/files/pil.5242.pdf

USEFUL DIAGNOSTIC TESTS
Calcium Test
Intact Parathyroid Hormone

PRODUCT DETAILS

Net Qty
1 N
Shelf Life
24 Months

Item Weight
120 g

Ingredient
ZOLEDRONIC ACID 5MG

Hsn Code
30049095
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Natzold 5mg Infusion 100ml

US$93.00US$160.00 (-42%)

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