Deriphyllin Injection 2ml

USES OF DERIPHYLLIN INJECTION

To treat:

• Asthma
• Chronic Bronchitis
• Chronic Obstructive Pulmonary Disease (COPD)

HOW DERIPHYLLIN INJECTION WORKS

DERIPHYLLIN INJECTION works by relaxing the smooth muscles in the airway in which etofylline works by dilating and relaxing the airway muscles and theophylline relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels, reduces the airway responsiveness to allergens thereby reducing inflammation.

DIRECTIONS FOR USE

DERIPHYLLIN INJECTION will be given to you only by a doctor or a nurse into the veins (intravenously). Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.

SIDE EFFECTS OF DERIPHYLLIN INJECTION

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink lots of or fruit juice to keep yourself hydrated. If the symptom does not show improvement, consult your doctor.

Headache

Avoid bright lights, drink more water, and take rest. If the symptom does not show improvement, consult your doctor.

Nausea And Vomiting

Stick to simple meals. Avoid eating rich or spicy food. If the symptom does not show improvement, consult your doctor.

Stomach Pain

Try to rest and relax and have smaller and frequent meals. Keep a heat pad on stomach. If the symptom does not show improvement, consult your doctor.

WARNING & PRECAUTIONS

PREGNANCY

MONITORING REQUIRED

DERIPHYLLIN INJECTION is not recommended for use in pregnant women or women planning to be pregnant uncles clearly necessary. Consult your doctor before receiving DERIPHYLLIN INJECTION.

BREASTFEEDING

CONTRAINDICATED

DERIPHYLLIN INJECTION is not recommended for use in breastfeeding women as it is excreted in breastmilk. Consult your doctor before receiving it.

DRIVING AND USING MACHINES

SAFE

DERIPHYLLIN INJECTION has no or negligible effect on your ability to drive or use machines. Do not drive or use machines in case of adverse effects.

ALCOHOL

CONSULT YOUR DOCTOR

Do not consume alcohol while receiving DERIPHYLLIN INJECTION as it can alter the way this medicine works.

KIDNEY

USE WITH CAUTION

DERIPHYLLIN INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving it.

LIVER

USE WITH CAUTION

DERIPHYLLIN INJECTION should be used with caution in patients with liver disease. Consult your doctor before receiving it.

ALLERGY

CONTRAINDICATED

Do not receive DERIPHYLLIN INJECTION if you are allergic to Etofylline or Theophylline or any other ingredients of this medicine.

LUNGS

USE WITH CAUTION

DERIPHYLLIN INJECTION should be used with caution in patients with chronic bronchitis or lung failure. Consult your doctor before receiving it.

HEART DISEASE

USE WITH CAUTION

DERIPHYLLIN INJECTION should be used with caution in patients with heart disease, high blood pressure, heart failure or any other heart problems. Consult your doctor before receiving it.

USE IN PEDIATRICS

CONTRAINDICATED

DERIPHYLLIN INJECTION is not recommended for use in children below 6 months of age. Consult your doctor before receiving it.

USE IN GERIATRICS

USE WITH CAUTION

DERIPHYLLIN INJECTION should be used with caution in elderly patients above 55 years of age. Consult your doctor before receiving it.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving DERIPHYLLIN INJECTION, inform your doctor if you are taking any of the following medicine:

• Certain other medicines to treat asthma or breathing conditions that contain theophylline, aminophylline, salbutamol, terbutaline, zafirlukast, or salmeterol, steroids (Ex. prednisolone, hydrocortisone)
• Oral contraceptives
• St John’s Wort, fluvoxamine or lithium (for depression)
• Carbamazepine or phenytoin (for seizures, fits or convulsions)
• Adenosine, diltiazem, isoprenaline, mexiletine, propafenone, propranolol, verapamil or beta blockers, regadenoson or dipyridamol (for high blood pressure and other heart problems)
• Sulphinpyrazone or allopurinol (for gout)
• Carbimazole (for problems of thyroid gland)
• Cimetidine or nizatidine (to treat stomach ulcers, indigestion or heartburn)
• Antibiotics (Ex. ciprofloxacin, clarithromycin, erythromycin, enoxacin)
• Fluconazole (treat fungal infections)
• Rifampicin or isoniazid (treat tuberculosis)
• Ritonavir to treat HIV
• Medicines to thin your blood (Ex. warfarin)
• Disulfiram (treats alcoholism)
• You have recently had, or are going to have a flu injection

B. Drug-Food interaction:

• Avoid caffeinated drinks during this treatment

Overdosage:

DERIPHYLLIN INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like thirsty, have ringing in your ears or feel palpitations.

SYNOPSIS

MORE INFORMATION

• Keep DERIPHYLLIN INJECTION out of reach from children
• Do not store above 25°C

FAQs ABOUT DERIPHYLLIN INJECTION

Q: What is DERIPHYLLIN INJECTION used for?

A: DERIPHYLLIN INJECTION is used in the treatment of asthma, chronic bronchitis, and chronic obstructive pulmonary disorder. Consult your doctor for more information.

Q: Can DERIPHYLLIN INJECTION be received pregnant women?

A: DERIPHYLLIN INJECTIONis not recommended for use in pregnant women or women planning to be pregnant uncles clearly necessary. Consult your doctor before receiving it.

Q: Can DERIPHYLLIN INJECTION be used in patients with heart problems?

A: DERIPHYLLIN INJECTIONshould be used with caution in patients with heart disease, high blood pressure, heart failure or any other heart problems. Consult your doctor before receiving it.

Q: Can I consume alcohol while receiving DERIPHYLLIN INJECTION?

A: Do not consume alcohol while receiving DERIPHYLLIN INJECTION as it can alter the way this medicine works. Consult your doctor if you are addicted to alcohol.

Q: How does DERIPHYLLIN INJECTION work?

A: DERIPHYLLIN INJECTION works by relaxing the smooth muscles in the airway in which etofylline works by dilating and relaxing the airway muscles and theophylline relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels, reduces the airway responsiveness to allergens thereby reducing inflammation.

REFERENCES

1. KD Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Eighth Edition. 2019. Page –243-247.

2. Peter J. Barnes. Theophylline. [Accessed on 9th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033977/

3. J Zuidema, J Verhoeven, F W Merkus. Pharmacokinetics of etofylline after intravenous and oral administration to humans. [Accessed on 9th August 2022] https://pubmed.ncbi.nlm.nih.gov/7263108/

4. Siegfried Hameln GmbH. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 9th August 2022]. https://www.medicines.org.uk/emc/files/pil.6299.pdf, https://www.medicines.org.uk/emc/product/6299/smpc

5. Pubchem. Etofylline. [Revised on August 2022] [Accessed on 9th August 2022] https://pubchem.ncbi.nlm.nih.gov/compound/etofylline

6. NIH. Etofylline. [Accessed on 9th August 2021] https://drugs.ncats.io/drug/L164909TBI

7. Theophylline. Mayoclinic.[Revised on February 2022] [Accessed on 9th August 2022] https://www.mayoclinic.org/drugs-supplements/theophylline-intravenous-route/description/drg-20073548

8. Etofylline, Theophylline. Mayoclinic. [Revised in April 2020] [Accessed on 9th August 2022] https://www.mayoclinic.org/diseases-conditions/copd/symptoms-causes/syc-20353679

USEFUL DIAGNOSTIC TESTS

• Lung function test
• Chest X-ray
• CT scan

AUTHOR DETAILS

Written By Dr. Dhivakaran R, BDS
Last updated on 13 Feb 2023 | 01:29 PM(IST)