INTRODUCTION
CORMUZIK +/ OINTMENT is a combination of Fluticasone and Mupirocin which belongs to the group of medicines called Corticosteroids and Antibiotics respectively. It is used to treat and manage steroid-responsive inflammatory disorders of the skin where secondary bacterial infections are present, suspected, or likely to occur.
These include atopic dermatitis, nummular dermatitis (discoid eczemas), irritant or allergic contact dermatitis, seborrhoeic dermatitis, prurigo nodularis, psoriasis (excluding widespread plaque psoriasis), lichen simplex chronicus (neurodermatitis) and lichen planus, discoid lupus erythematosus, insect bite reactions, and miliaria (prickly heat).
Dermatitis is a common skin irritation which has many causes and forms and usually involves itchy, dry skin or a rash, blistering, oozing, crust or flake off. Psoriasis is a long-term skin disease that causes a rash with itchy, scaly patches, most commonly on the knees, elbows, trunk, and scalp which can be painful, interfere with sleep and make it hard for you to focus.
During course of the treatment your doctor might regularly examine your skin to avoid any untoward side effects.
CORMUZIK +/ OINTMENT is not recommended for long-term continuous use in infants, children and adolescents under 12 years of age.
Before using CORMUZIK +/ OINTMENT inform your doctor if you have skin conditions such as rosacea, acne vulgaris, perioral dermatitis, pruritus without inflammation, perianal and genital pruritus, primary or secondary viral, yeast, fungal and bacterial infections, or dermatoses in infants under 3 months of age.
CORMUZIK +/ OINTMENT should be used in pregnant and breastfeeding women only if specifically directed by your doctor.
The most common side effects of using CORMUZIK +/ OINTMENT are burning, or itching. Contact your doctor if any of the side effects worsen.
USES OF CORMUZIK +/ OINTMENT
It is used to treat and manage:
Atopic, nummular, irritant or allergic contact, and seborrhoeic dermatitis
Prurigo nodularis
Psoriasis
Lichen simplex chronicus and lichen planus
Discoid lupus erythematosus
Insect bite reactions
Miliaria
HOW CORMUZIK +/ OINTMENT WORKS
CORMUZIK +/ OINTMENT relieves skin infection and inflammation where fluticasone exerts a direct local effect of blood vessel constriction and anti-inflammatory action by decreasing inflammatory cells like eosinophils, monocytes, mast cells, macrophages, and dendritic cells, along with the number of cytokines they produce, and decreasing mucus gland secretions. Mupirocin mediates its antibacterial activity by blocking the bacterial protein synthesis and formation of bacterial proteins essential for survival.
DIRECTIONS FOR USE
Apply CORMUZIK +/ OINTMENT as advised by your physician. It is for external use only. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF CORMUZIK +/ OINTMENT
COMMON
Burning, itching
UNCOMMON
Redness
Stinging and dryness (area of application)
Cutaneous sensitization reactions
RARE
Stop using CORMUZIK +/ OINTMENT and consult your doctor immediately if you experience any of the following side effects:
Symptoms of Cushing’s syndrome and reversible hypothalamic-pituitary adrenal (HPA) axis suppression
Blurred vision or other visual disturbances
WARNING & PRECAUTIONS
PREGNANCY
CORMUZIK +/ OINTMENT should be used in pregnant women only if specifically directed by your doctor. Consult your doctor before using the medicine.
BREASTFEEDING
CORMUZIK +/ OINTMENT should be used in breastfeeding women only if specifically directed by your doctor. It should not be applied to the breasts to avoid accidental ingestion by the baby. Consult your doctor before using the medicine.
KIDNEY
CORMUZIK +/ OINTMENT should be used in minimum quantity for the shortest duration in patients with kidney impairment. Consult your doctor before using it.
LIVER
CORMUZIK +/ OINTMENT should be used in minimum quantity for the shortest duration in patients with liver impairment. Consult your doctor before using it.
ALLERGY
Do not use CORMUZIK +/ OINTMENT if you are allergic to Fluticasone, Mupirocin or any other ingredients of this medicine.
OTHERS
CORMUZIK +/ OINTMENT is not recommended for use if you have:
Rosacea
Acne vulgaris
Perioral dermatitis
Pruritus without inflammation
Perianal and genital pruritus
Primary or secondary viral, yeast, fungal and bacterial infections
Use in pediatrics:
CORMUZIK +/ OINTMENT should be used with caution in children and infants aged 3 months and over. Your doctor will prescribe the right dose depends on your child’s age, body weight and severity of infection. Consult your doctor before using it.
Use in geriatrics:
CORMUZIK +/ OINTMENT should be used in minimum quantity for the shortest duration in elderly patients. Consult your doctor before using it.
INTERACTIONS
A. Drug – Drug interactions:
Before using CORMUZIK +/ OINTMENT inform your doctor if you are taking any of the following medicines:
Ritonavir (used to treat HIV infection)
Itraconazole (used to treat fungal infection)
Overdosage:
If you or anyone else accidentally uses too much of CORMUZIK +/ OINTMENT, contact your doctor immediately or visit the nearby hospital.
SYNOPSIS
Drug : Fluticasone, Mupirocin
Pharmacological Category : Corticosteroids, Antibiotic
Therapeutic Indication : Skin infection and inflammation
Dosage Forms : Cream, Ointment
MORE INFORMATION
Keep CORMUZIK +/ OINTMENT out of reach of children
Do not store above 25°C
FAQs ABOUT CORMUZIK +/ OINTMENT
Can I stop using CORMUZIK +/ OINTMENT?
Do not stop using CORMUZIK +/ OINTMENT unless your doctor advises you to stop. Treatment with topical corticosteroids should be gradually withdrawn once control is achieved as rebound of pre-existing skin disease can occur with abrupt discontinuation.
Can I use CORMUZIK +/ OINTMENT for acne?
Do not use CORMUZIK +/ OINTMENT for conditions other than that prescribed for, and it is not recommended for use in acne vulgaris. Consult your doctor before using it.
Can I apply CORMUZIK +/ OINTMENT on the face?
Long-term application of CORMUZIK +/ OINTMENT on the face is not recommended, as this area is more susceptible to atrophic changes. Consult your doctor before using it.
Can CORMUZIK +/ OINTMENT be used for psoriasis?
CORMUZIK +/ OINTMENT should be used with caution in psoriasis as rebound, tolerance, risk of generalized pustular psoriasis and local or systemic toxicity due to impaired barrier function of the skin can occur. Careful patient supervision is important when used in psoriasis. Consult your doctor before using it.
What if CORMUZIK +/ OINTMENT accidentally gets into my eye?
Avoid contact of CORMUZIK +/ OINTMENT with the eyes to ensure it does not enter the eye as cataract and glaucoma might result from repeated exposure. If contaminated, wash your eyes thoroughly with water until the medicine residues have been removed. Consult your doctor if you feel any eye discomfort.
REFERENCES
1. Kailey Remien, Andy Bowman. Fluticasone. StatPearls. StatPearls Publishing. November 2021. [Accessed on 31st May 2022] https://www.ncbi.nlm.nih.gov/books/NBK542161/#article-37573.s3
2. M A Parenti, S M Hatfield, J J Leyden. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 1987. [Accessed on 31st May 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Mupirocin#section=Pharmacology
3. GlaxoSmithKline Pharmaceuticals Limited. Fluticasone Propionate and Mupirocin Ointment. [Revised in October 2021] [Accessed on 31st May 2022] https://india-pharma.gsk.com/media/6377/flutibact-skin-ointment.pdf
4. Fluticasone Propionate and Mupirocin. Canbro Healthcare. [Accessed on 31st May 2022] https://www.canbro.in/product/fluticasone-propionate0-005-mupirocin-2-in-a-cream-base
5. Mayo Clinic. Dermatitis. [Accessed on 31st May 2022] https://www.mayoclinic.org/diseases-conditions/dermatitis-eczema/symptoms-causes/syc-20352380
6. Mayoclinic. Psoriasis. [Accessed on 31st May 2022] https://www.mayoclinic.org/diseases-conditions/psoriasis/symptoms-causes/syc-20355840#:~:text=Psoriasis%20is%20a%20skin%20disease,make%20it%20hard%20to%20concentrate
Net Qty
1 N
Ingredient
FLUTICASONE PROPIONATE 0.005%+MUPIROCIN 2%
Hsn Code
30039090
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