INTRODUCTION
BRIV contains Brivaracetam which belongs to a group of medicines called anti-epileptics. It is used to treat partial seizures. Epilepsy is a condition due to sudden, uncontrolled electrical disturbance in the brain which causes changes in behavior, movements or feelings and levels of consciousness and partial seizures are seizures which affects one side of the brain which spreads and extend to larger areas on both sides of the brain which is called a secondary generalisation.
This medicine is used to treat a type of epilepsy that has partial seizures with or without a secondary generalisation. It is used to lower the number of fits (seizures) and also used together with other medicines for epilepsy. It works by attaching itself to specific sites (SV2A) on the surfaces of nerve cells which suppresses the abnormal activity of the nerve cells in the brain and prevents the spread of electrical signals that cause seizures.
Take this medicine as instructed by your doctor. Your doctor will prescribe the dose depends on your age, other medications you are taking and whether you have any kidney or liver problems. It is not suitable for use in children below 4 years of age, pregnant women and breastfeeding mothers. The most common side effects of BRIV are flu, dizziness, tiredness or sleepiness.
USES OF BRIV
Treat partial seizures
HOW BRIV WORKS
BRIV works by attaching itself to specific sites (SV2A) on the surfaces of nerve cells which suppresses the abnormal activity of the nerve cells in the brain and prevents the spread of electrical signals that cause seizures.
DIRECTIONS FOR USE
Take this medicine as directed by your physician. Shake well before use. Dilute it in water or juice shortly before swallowing. It can be taken with or without food.
SIDE EFFECTS OF BRIV
COMMON
Sleepiness or dizziness
Flu
Tiredness (fatigue)
Convulsion (vertigo)
Feeling and being sick
Constipation
Depression, anxiety, not being able to sleep and irritability
Common cold or cough
Decreased appetite
Children: restlessness and hyperactivity
HOW TO MANAGE SIDE EFFECTS
Feeling and being sick:
Stick to regular meals and do not eat spicy foods.
Dizziness:
Get up and move around to feel awake, give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Constipation:
Add fruits, vegetables whole grains and fiber foods to your normal diet.
Flu:
Drink plenty of water, juice and warm soups to prevent dehydration.
WARNING & PRECAUTIONS
PREGNANCY
BRIV is not recommended for use in pregnant women unless necessary. Consult your doctor for advice.
BREASTFEEDING
BRIV is not recommended for use in breastfeeding women unless necessary. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or handle any machines while taking this medicine, since it may cause sleepiness, dizziness or tiredness.
ALCOHOL
Consumption of alcohol is not recommended during treatment with BRIV.
LIVER
BRIV should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Brivaracetam.
OTHERS
Inform your doctor if you have or had condition such as,
Psychotic disorders (suicidal thoughts)
INTERACTIONS
Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,
Rifampicin (treats bacterial infections)
St John’s wort (treats depression and anxiety)
SYNOPSIS
Drug : Brivaracetam
Pharmacological Category : Anticonvulsant
Therapeutic Indication : Partial-onset seizures
Dosage Forms : Tablet, Injection, Syrup
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT BRIV
Can BRIV be given in children?
It is not suitable for children under 4 years of age.
What are the most common side effects of BRIV?
The most common side effects are sleepiness, dizziness, feeling tired or nausea and vomiting
What if my seizures stop and feeling good? Do i still need to take BRIV?
Avoid stop taking your medicine without consulting your doctor.
REFERENCES
1. Roger J. Porter, MD, & Michael A. Rogawski. Anti-seizure Drugs. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page – 423.
2. Farbod Khaleghi and Eric C. Nemec. Brivaracetam: A Novel Adjunctive Therapy for Partial-Onset Seizures. Feb, 2017. [Accessed on March 26, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265234/
3. Pavel Klein, Anyzeila Diaz, Teresa Gasalla and John Whitesides. A review of the pharmacology and clinical efficacy of brivaracetam, Jan 19, 2018. [Accessed on March 26, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783144/
4. UCB Pharma S.A., Electronic Medicines Compendium (EMC); [Revised on Oct 2020] [Accessed on March 26, 2021] https://www.medicines.org.uk/emc/files/pil.1964.pdf
5. UCB, Inc., Smyrna, 2016, U.S. Food & Drug Administration; [Revised on May, 2018] [Accessed on March 26, 2021] https://www.briviact.com/briviact-PI.pdf
Country Of Origin
India
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