INTRODUCTION

AVOMINE contains Promethazine which belongs to the group of medicines called Antihistamines. It is used to induce sleep in adults suffering from insomnia (difficulty in falling asleep) and in children aged 5 years or older. It can also be used to treat allergic reactions such as hay fever or skin rashes. It also helps to stop nausea and vomiting caused due to travelling (travel sickness).

Promethazine is an antihistamine with sedative properties. It acts by blocking the release of certain chemicals (histamines) in the body that causes allergic reactions and vomiting. It can also directly act on the brain and help you feel relaxed and calm.

Before taking AVOMINE, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have asthma, or other breathing problems, glaucoma, epilepsy, hearing problems or blockage in the gut before taking AVOMINE as a precaution.

Talk to your doctor before taking AVOMINE if you are already taking any medicines for depression. Avoid consumption of alcohol while taking AVOMINE as it may reduce its effectiveness. Consult your doctor before taking AVOMINE if you are pregnant or breastfeeding.

AVOMINE may cause excessive sleepiness or drowsiness. Therefore, avoid driving or operating any heavy tools or performing activities that requires complete attention. Other most common side effects of taking AVOMINE are dry mouth, blurred vision, headache, tiredness, skin sensitivity, dizziness, and indigestion. Contact your doctor if any of these side effect worsens.

Talk to your doctor if you cannot see any improvement in your condition even after using AVOMINE for the specific period prescribed for you.

USES OF AVOMINE

It is used as a short-term therapy to:

Treat insomnia (difficulty in falling asleep) in adults
Treat allergic conditions (such as hay fever or skin rashes)
Treat nausea and vomiting caused due to travel (travel sickness)
Induce sleep (sleeping aid) in children aged 5 years or older
HOW AVOMINE WORKS

AVOMINE is an antihistamine with anti-emetic and sedative properties. It acts by blocking the release of certain chemicals (histamines) in the body that causes allergic reactions and vomiting. It can also directly act on the brain and induce sleep by blocking the actions of certain chemical messengers (acetylcholine, glutamate, and dopamine) that hinders sleep and keeps you awake.

DIRECTIONS FOR USE

Take AVOMINE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Continue to take AVOMINE for the stipulated duration prescribed by your doctor to achieve better results.

SIDE EFFECTS OF AVOMINE
COMMON
Dry mouth
Blurred vision
Difficulty in passing urine
Feeling tired, sleepy, dizzy, drowsy, or faint
Headache, sleep problems
Loss of appetite, indigestion
Feeling confused, especially in elderly people
Increased skin sensitivity towards sun
Urge to move your legs frequently (Restless Legs Syndrome)
RARE

Stop taking AVOMINE and contact your doctor immediately if you experience any of the following side effects:

Signs of allergic reaction (such as skin rash, swallowing or breathing problems, swelling of the lips, face, throat, or tongue)
Signs of liver problems (such as yellowing of the skin and eyes)
Muscle stiffness or shaking
Unable to control the muscles of the face or head, facial muscle spasms, rolling eyes and trembling
Irregular or rapid heartbeat
Anaemia symptoms such as tiredness
Over-active behaviour in children
HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Feeling sleep, dizzy, or drowsy:

Try to rest and relax. Get enough sleep. Avoid driving or operating any heavy tools or machines completely while you are feeling sleepy or dizzy. Do not consume excessive alcohol. Consult your doctor if your condition worsens.

Dry mouth:

Drink plenty of water or fluids at regular intervals. Frequent small sips of water or the use of artificial saliva may be beneficial. However, if it bothers you or if your condition worsens contact your doctor.

WARNING & PRECAUTIONS
PREGNANCY

AVOMINE should be used in pregnant women only if prescribed by the physician. However, it is not recommended for use in pregnant women during the last few weeks (2 weeks) of pregnancy. Therefore, consult your doctor before taking it.

BREASTFEEDING

AVOMINE is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Therefore, consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines after taking AVOMINE. This is because, AVOMINE may cause excessive sleepiness or drowsiness which can hinder your abilities of driving or handling machines.

ALCOHOL

Avoid consumption of alcohol while taking AVOMINE as it may reduce its effectiveness.

KIDNEY

AVOMINE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

LIVER

AVOMINE should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take AVOMINE if you are allergic to Promethazine.

LUNGS

AVOMINE should be used with caution in patients with bronchitis (inflammation of the bronchus), asthma or other breathing difficulties. Therefore, consult your doctor before taking it.

HEART DISEASE

AVOMINE should be used with caution in patients with any serious heart problems. Therefore, consult your doctor before taking it.

OTHERS

AVOMINE is not recommended for use if you:

Suffer from severe dizziness, drowsiness, or headache
Are in unconscious or coma state

Before taking AVOMINE, inform your doctor if you:

Have epilepsy
Have blockage in the gut
Have difficulty in passing urine
Have problems in hearing
Have narrow angle glaucoma (increased pressure in the eye)
Have or had Reye’s Syndrome (vomiting, tiredness and confusion following a viral infection) in the past
Are going for a pregnancy test or skin test

Use in pediatrics:

AVOMINE should be used in children and adolescents (aged 5 years or older) only if prescribed by the physician. It is not recommended for use in children aged below 5 years. Therefore, consult your doctor before taking it.

Use in geriatrics:

AVOMINE should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug Interaction:

Before taking AVOMINE, inform your doctor if you are taking any of the following:

Medicines used to treat depression such as monoamine oxidase inhibitors (Ex. fluoxetine, selegiline, phenelzine, isocarboxazid)
Anticholinergic medicines (used to improve heart rate, decrease muscle movements, and body secretions) Ex. atropine, dicyclomine
Diazepam or zolpidem (used to induce sleep)
Aspirin (a medicine used for pain relief or blood thinning)

Overdosage:

If you or anyone else accidentally took more AVOMINE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include hyperactivity, unsteady movements, uncontrolled writhing movements especially of the hands or feet, hallucinations, fits, very fast or uneven heartbeat, breathing problems and excessive sleepiness or drowsiness.

SYNOPSIS
Drug : Promethazine
Pharmacological Category :

Phenothiazines

Therapeutic Indication :

Insomnia, Sedation, Nausea, Vomiting, Allergic reactions

Dosage Forms :

Tablet, Injection, Syrup

MORE INFORMATION
Keep AVOMINE out of reach of children
Store AVOMINE at room temperature
FAQs ABOUT AVOMINE

Can the use of AVOMINE make me feel sleepy?

Yes. AVOMINE may cause excessive sleepiness or drowsiness. Therefore, avoid driving or operating any heavy tools or performing activities that requires complete attention. Try to rest and relax. Get enough sleep. Do not consume excessive alcohol. Consult your doctor if your condition worsens.

Can the use of AVOMINE make me feel high?

Yes. The use of AVOMINE may cause excitement, agitation, or highs, especially in the children. This happens due to the effects of promethazine on the central nervous system. Talk to your doctor immediately if you or your child experiences any such symptoms.

Can AVOMINE be used in children?

Yes. AVOMINE can be used in children (aged 5 years or older) if prescribed by the physician. It is not suitable for use in children aged below 5 years. Therefore, consult your doctor before taking it.

Can AVOMINE be used to treat morning sickness during pregnancy?

No. AVOMINE should be used in pregnant women only if it is considered necessary by the physician. It is strictly not recommended for use in pregnant women during the last few weeks (2 weeks) of pregnancy. Therefore, consult your doctor before taking it.

What is the use of AVOMINE?

AVOMINE is used to induce sleep in adults suffering from insomnia and in children aged 5 years or older. It can also be used to treat allergic reactions (such as hay fever or skin rashes) and stops nausea and vomiting caused due to travelling.

Is AVOMINE good for vertigo?

AVOMINE may be effective in treating vertigo (sensation of spinning) due to its anti-emetic properties. However, consult your doctor before taking.

Can I take AVOMINE with paracetamol?

Yes. AVOMINE can be taken along with paracetamol But, before taking any medicines along with AVOMINE consult your doctor for advice.

How long does it take for AVOMINE to start working?

AVOMINE is a fast-acting medicine. It starts working within 20 minutes following administration and its effects may last up to 4-6 hours or even longer.

Can I stop taking AVOMINE once my symptoms subside?

No. Do not stop taking AVOMINE without consulting your doctor as it may cause the symptoms to reappear. Make sure to take AVOMINE for the stipulated duration recommended by your doctor to achieve the maximum results.

What should I do if I forgot to take a dose of AVOMINE?

If you forgot a dose of AVOMINE, take it as soon as you remember. However, if it is time for the next dose, skip the missed one and take the next one at regular times. Do not take a double dose of AVOMINE to compensate the missed ones.

Will taking a higher dose of AVOMINE be more effective?

Do not consume a higher dose of AVOMINE than the one prescribed by your doctor, as it may lead to unwanted side effects. Your doctor will decide the correct dose for you, depending on your age body weight and disease condition. If the prescribed dose, does not help you, contact your doctor.

Can AVOMINE cause dryness of mouth?

Yes. AVOMINE may cause dryness of mouth. If you experience mouth dryness, drink plenty of water or fluids at regular intervals. Frequent small sips of water may be beneficial. However, if it bothers you or if your condition worsens contact your doctor.

REFERENCES

1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 220.

2. Brittin T. Southard; Yasir Al Khalili. Promethazine. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. May 2022. [Accessed on 11th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK544361/

3. FAMAR HEALTH CARE SERVICES MADRID, S.A.U. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 7th June 2022] https://www.medicines.org.uk/emc/files/pil.5587.pdf

4. Teva Operations Poland Sp. Z o.o, UI. Promethazine Hydrochloride Tablet. [Revised in March 2020] [Accessed on 7th June 2022] https://products.tevauk.com/mediafile/id/48737.pdf

USEFUL DIAGNOSTIC TESTS
Absolute Eosinophil Count
Peripheral Smear Examination
Total IgE
PRODUCT DETAILS
Net Qty
1 N
Item Weight
17.5 g
Ingredient
PROMETHAZINE 25MG
Hsn Code
30049031
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