Voritrol 200mg Tablet 4’S

INTRODUCTION

VORITROL 200MG TABLET contains Voriconazole which belongs to the group of medicines called Antifungal agents. It is used to treat various fungal infections (such as invasive aspergillosis, candidaemia, invasive Candida sp. infections) in both adults and in children (aged 2 years or above). It can also be used to prevent fungal infections in high-risk bone marrow transplant recipients.

VORITROL 200MG TABLET should be taken at least 1 hour before or after meals. It is highly intended for patients with worsening or life-threatening fungal infections. It is important to complete the full course of therapy with VORITROL 200MG TABLET to achieve better control over infection.

Before taking VORITROL 200MG TABLET inform your doctor if you have any liver or heart problems. Do not take VORITROL 200MG TABLET if you are pregnant or breast-feeding without consulting your doctor.

Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with VORITROL 200MG TABLET. During treatment with VORITROL 200MG TABLET, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors.

The most common side-effects of taking VORITROL 200MG TABLET are visual impairment, fever, rash, nausea, vomiting, diarrhoea, headache, swelling of the extremities, stomach pain and breathing difficulties. Consult your doctor if any of these side effect troubles you.

USES OF VORITROL 200MG TABLET

It is used in adults and in children (aged 2 years or older) to:

Treat and prevent severe fungal infections
HOW VORITROL 200MG TABLET WORKS

VORITROL 200MG TABLET is an antifungal medication. It effectively controls fungal infections within the body. It disrupts the fungal cell membrane by blocking the production of certain chemicals (ergosterol) within the cell which is required for its survival. As a result, it stops the fungal cell from multiplication, thereby preventing the further spread of infection.

DIRECTIONS FOR USE

Take VORITROL 200MG TABLET 1 hour before or after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking VORITROL 200MG TABLET without consulting your doctor.

SIDE EFFECTS OF VORITROL 200MG TABLET
COMMON
Vision problems (such as blurred vision, colour changes, light sensitivity)
Fever, chills, weakness
Headache, dizziness, sleepiness
Nausea, vomiting, diarrhoea, stomach pain
Constipation, indigestion
Swelling of the extremities
Inflammation of the sinuses
Low RBC, WBC and platelet count in blood
Low blood sugar levels, low blood pressure
Low blood potassium or sodium levels
Breathing difficulties
Anxiety, depression, inability to sleep
Fits
Hair loss
UNCOMMON
Enlarged lymph glands
Problems in adrenal gland
Underactive thyroid gland
Feeling shaky
Abnormal sense of taste
Hearing difficulties, vertigo, ringing in the ears
Increased blood cholesterol and urea levels
RARE

Stop taking VORITROL 200MG TABLET and contact your doctor immediately if you experience any of the following side effects:

Signs of allergic reactions (such as severe skin rash with itching, blistering and peeling of the skin, mouth, eyes, throat, genitals, swelling of the face and tongue, bleeding under the skin causing appearance of red-pin point dots on the skin, skin swelling, along with fever, tiredness, confusion or jaundice)
Skin rashes, sun burn
Bone pain, inflammation of the tissue surrounding the bone
Skin cancer
Red, scaly patches or ring-shaped skin lesions
Jaundice (yellowing of the skin and whites of the eye)
Signs of adrenal insufficiency (such as severe tiredness, weak muscles, loss of appetite, weight loss, stomach pain)
Signs of Cushing’s syndrome (such as round face, weight gain, fatty hump between the shoulders, dark skin, skin thinning, easy bruising, high blood sugar levels, excessive hair growth and excessive sweating)
HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try to take VORITROL 200MG TABLET with or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

WARNING & PRECAUTIONS
PREGNANCY

VORITROL 200MG TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with VORITROL 200MG TABLET.

BREASTFEEDING

VORITROL 200MG TABLET should be used with caution in breastfeeding women. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you experience vision problems after taking VORITROL 200MG TABLET.

LIVER

VORITROL 200MG TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take VORITROL 200MG TABLET if you are allergic to Voriconazole or to any other azole antifungal agents (such as fluconazole, ketoconazole).

HEART DISEASE

VORITROL 200MG TABLET should be used with caution in patients with heart problems (such as cardiomyopathy, irregular or slow heart rate, prolong QT interval). Therefore, consult your doctor before taking it.

OTHERS

Use in paediatrics:

VORITROL 200MG TABLET is not recommended for use in children under 2 years of age. Therefore, consult your doctor before taking it.

Use in geriatrics:

VORITROL 200MG TABLET can be used with caution in elderly patients. Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug – Drug Interactions:

Before taking VORITROL 200MG TABLET, inform your doctor if you are taking any of the following medicines such as:

Medicines used for allergy (Ex. terfenadine, astemizole)
Medicines used for symptoms of chronic heart failure (Ex. ivabradine)
Medicines used for stomach problems (Ex. cisapride)
Medicines used for treating mental illness (Ex. pimozide, phenytoin, phenobarbital, midazolam, triazolam and lurasidone)
Carbamazepine, phenytoin (medicines used to treat fits)
Medicines used for irregular heartbeat (Ex. quinidine)
Medicines used for treating tuberculosis (Ex. rifampicin, rifabutin)
Medicines used for treating HIV (Ex. efavirenz, ritonavir, efavirenz, delavirdine, nevirapine)
Medicines used for migraine (Ex. ergotamine, dihydroergotamine)
Medicines used in transplant patients (Ex. sirolimus, ciclosporin, tacrolimus)
St. John’s Wort (herbal supplement used to treat depression)
Medicines used to treat constipation (Ex. naloxegol)
Medicines used to treat hyponatremia (Ex. tolvaptan)
Medicines used in treating patients with blood cancer (Ex. venetoclax)
Medicines used for treating cancer (Ex. glasdegib, vincristine, vinblastine)
Warfarin (a medicine used to prevent blood clotting)
Medicines used for diabetes (Ex. tolbutamide, glipizide, glyburide)
Medicines used for lowering cholesterol (Ex. atorvastatin, simvastatin)
Medicines used for treating stomach ulcers (Ex. omeprazole)
Oral contraceptives (used to prevent pregnancy) Ex. ethinylestradiol
Medicines used to treat drug addiction (Ex. methadone)
Painkillers used for surgical procedures (Ex. alfentanil, fentanyl, sufentanil)
Medicines used to treat moderate to severe pain (Ex. oxycodone, hydrocodone, ibuprofen, diclofenac)
Other medicines used to treat fungal infections (Ex. fluconazole)
Medicines used for treating advanced kidney cancer and in transplant patients (Ex. everolimus)
Medicine used for preventing cytomegalovirus (CMV) disease after bone marrow transplant (Ex. letermovir)
Medicines used to treat cystic fibrosis (Ex. ivacaftor)

Overdosage:

If you or anyone else accidentally took more VORITROL 200MG TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS
Drug :   Voriconazole
Pharmacological Category :   Azole Antifungal agents
Therapeutic Indication :   Fungal Infections
Dosage Forms :   Tablet, Injection, Eye Drops
MORE INFORMATION
Keep VORITROL 200MG TABLET out of reach of children
Store VORITROL 200MG TABLET at room temperature
FAQs ABOUT VORITROL 200MG TABLET

What is the use of VORITROL 200MG TABLET?

VORITROL 200MG TABLET is used to treat various fungal infections (such as invasive aspergillosis, candidaemia, invasive Candida sp. infections) in both adults and in children (aged 2 years or above). It can also be used to prevent fungal infections in high-risk bone marrow transplant recipients.

How VORITROL 200MG TABLET works?

VORITROL 200MG TABLET is an antifungal medication. It effectively controls fungal infections within the body. It disrupts the fungal cell membrane by blocking the production of certain chemicals (ergosterol) within the cell which is required for its survival. As a result, it stops the fungal cell from multiplication, thereby preventing the further spread of infection.

How to take VORITROL 200MG TABLET?

Take VORITROL 200MG TABLET 1 hour before or after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

How long should I take VORITROL 200MG TABLET?

You need to take VORITROL 200MG TABLET for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

What to do if I forgot to take a dose of VORITROL 200MG TABLET?

If you forgot to take a dose of VORITROL 200MG TABLET, take it as soon as you remember. However, if it is time for the next dose of VORITROL 200MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of VORITROL 200MG TABLET to compensate the missed ones.

Is VORITROL 200MG TABLET safe?

VORITROL 200MG TABLET is safe at doses prescribed by the physician. Therefore, do not alter the dose of VORITROL 200MG TABLET without consulting your doctor.

Can I stop taking VORITROL 200MG TABLET without consulting your doctor?

No. You should not stop taking VORITROL 200MG TABLET without consulting your doctor as it may reduce its effectiveness. Therefore, take VORITROL 200MG TABLET for the stipulated duration recommended by your doctor to achieve maximum results.

What happens if I take too more of VORITROL 200MG TABLET?

If you or anyone else accidentally took more VORITROL 200MG TABLET, consult your doctor immediately or visit the nearby hospital.

Will taking a higher dose of VORITROL 200MG TABLET be more effective?

No, taking a higher dose of VORITROL 200MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Can VORITROL 200MG TABLET be used in pregnant women?

VORITROL 200MG TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.

How much VORITROL 200MG TABLET should I take?

VORITROL 200MG TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

REFERENCES

1. KD. Tripathi. Anti-Fungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 795.

2. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Voriconazole. [Accessed on 22nd November 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Voriconazole

3. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2022]. [Accessed on 22nd November 2022] https://www.medicines.org.uk/emc/files/pil.4415.pdf

USEFUL DIAGNOSTIC TESTS
Complete Blood Count
Liver Function Test
Kidney Function Test
Net Qty
1 N
Item Weight
10 g
Ingredient
VORICONAZOLE 200MG
Hsn Code
30049099
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