ZOLFRAC contain zoledronic acid which belongs to a group of medicine called bisphosphonates. It is used to prevent bone complications such as fractures, bone metastases in adult patients and helps in reducing the amount of calcium in the blood in a condition called tumour-induced hypercalcaemia (TIH) in adult patients. Tumour can accelerate normal bone change in such a way that the release of calcium from bone is increased.
ZOLFRAC works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bone and minimize the risk of fracture. This medicine is strictly not recommended for use in children and adolescents under 18 years of age. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF ZOLFRAC
Prevent bone complications (e.g., fractures, in adult patients with bone metastases (spread of cancer from primary site to the bone))
Reduce the amount of calcium in tumour-induced hypercalcaemia (TIH) in adult patients
HOW ZOLFRAC WORKS
ZOLFRAC works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bone and minimize the risk of fracture.
DIRECTIONS FOR USE
ZOLFRAC will be administered by a doctor or nurse. It will be given as a drip (infusion) into a vein. Your doctor will decide the dose and frequency depending on your condition.
SIDE EFFECTS OF ZOLFRAC
Severe kidney impairment
Low level of calcium in the blood
Low level of phosphate in the blood
Flu-like syndrome such as fever, fatigue, weakness, drowsiness, chills, and bone, joint and/or muscle ache
Gastrointestinal reaction such as nausea, vomiting, loss of appetite
Low level of red blood cells (anaemia)
Unusual fracture of the thigh bone
Discomfort in your thigh, hip
Interstitial lung disease (inflammation of the tissue around the air sacks of the lungs)
HOW TO MANAGE SIDE EFFECTS
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Drink plenty of fluids and water. Avoid taking cold bath or showers.
Nausea and vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
WARNING & PRECAUTIONS
ZOLFRAC is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
ZOLFRAC is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machine while taking this medicine as it may cause drowsiness, sleepiness.
Consumption of alcohol is not recommended during treatment with ZOLFRAC.
ZOLFRAC should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
Do not take ZOLFRAC if you are allergic (hypersensitive) to zoledronic acid or any other ingredients in this medicine.
Tell your doctor if you have or had a condition such as,
Pain, swelling or numbness of the jaw, a feeling of heaviness in the jaw or loosening of a tooth
Dental treatment or are due to undergo dental surgery
Irregular heartbeat (cardiac arrhythmia), seizures, spasm and twitching (tetany) (secondary to severe hypocalcaemia)
Patients aged 65 years and over
Talk to your doctor if you are taking,
Aminoglycosides (used to treat severe infections)
Thalidomide (used to treat a certain type of blood cancer involving the bone)
Anti-angiogenic medicines (used to treat cancer)
Drug : Zoledronic acid
Pharmacological Category : Bisphosphonate Derivative
Therapeutic Indication : Bone complications
Dosage Forms : Injection
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT ZOLFRAC
Can I take ZOLFRAC during pregnancy?
No, it is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your Doctor.
Can I take ZOLFRAC during breastfeeding?
No, it is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your Doctor.
Can ZOLFRAC cause headache?
Yes, this medicine may cause headache in some individuals. Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page – 4229-4231.
2. J R Berenson 1. Zoledronic acid in cancer patients with bone metastases: results of Phase I and II trials. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Apr 2001. [Accessed 21 Dec 2020] https://pubmed.ncbi.nlm.nih.gov/11346862/
3. Agila Specialties Polska Sp. Zo.; Electronic Medicines Compendium (EMC); [Revised on 20 Oct 2015] [Accessed 21 Dec 2020] https://www.medicines.org.uk/emc/files/pil.7205.pdf
USEFUL DIAGNOSTIC TESTS
Intact Parathyroid Hormone
ZOLEDRONIC ACID 5MG
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