Zoladex 3.6mg Injection 1’s

Zoladex 3.6mg Injection 1’s

ZOLADEX 3.6MG contains Goserelin which belongs to a group of medicines called Luteinising hormone-releasing hormone (LHRH) analogues. It is used to treat prostate cancer (in men), breast cancer, endometriosis, uterine fibroids, infertility (with other medicines) which helps to control the release of eggs from the ovaries (in women).

Goserelin is a long-acting GnRH agonist which is classified as a leutinizing hormone releasing hormone (LHRH) agonist. LHRH agonists work by inhibiting the production of lutenizing hormone by the pituitary gland. This stimulates the testicles to release testosterone in men and stimulates the ovaries to release estrogen in women. This medicine does not have a direct effect on the cancer but act only on the testicles or ovaries. The lack of testosterone and estrogen interferes with stimulating cell growth in testosterone or estrogen dependent cancer cells. In treatment of prostate cancer ZOLADEX 3.6MG are often used together with anti-androgen medications. Anti-androgens are substances which block the effects of testosterone.

Before receiving this ZOLADEX 3.6MG, tell your doctor if you have liver, kidney or heart problems. It is not recommended for use in children, pregnant women and breastfeeding mothers. Your healthcare provider will inject under the skin (subcutaneous) on your stomach every four weeks (28 days). The common side effects are hot flushes, sweating, decreased sex drive and thinning of bones.

USES OF ZOLADEX 3.6MG

Treats,

Prostate cancer (in men)
Breast cancer, endometriosis, uterine fibroids, infertility (in women)
HOW ZOLADEX 3.6MG WORKS

ZOLADEX 3.6MG is a gonadotropin-releasing hormone (GnRH) analog. In men it works by reducing the amount of testosterone (hormone) that is produced by body. In women, it works by reducing the amount of oestrogen (hormone). LHRH agonists work by telling the pituitary gland located in the brain to stop producing leutinizing hormone, which stimulates the testicles to release testosterone in men and stimulates the ovaries to release estrogen in women.

DIRECTIONS FOR USE

ZOLADEX 3.6MG will be injected by your doctor or nurse under the skin on your stomach every four weeks (28 days).

SIDE EFFECTS OF ZOLADEX 3.6MG
SERIOUS
Abdominal pain or distension
Shortness of breath
Dizziness
Low blood pressure or any altered levels of consciousness
COMMON
Hot flushes and sweating
Decreased sex drive
Pain, bruising, bleeding, redness or swelling (injection site)
Thinning of bones
Skin rashes
Swelling and tenderness of breasts
Impotence, pain in lower back or problems passing urine, bone pain, reduced heart function and increased blood sugar levels (in men)
Dryness of vagina, acne and headache (in women)
RARE
Rash, itching or hives on the skin.
Swelling of the face, lips or tongue or other parts of the body
Wheezing or trouble breathing
Small cysts (swellings) on the ovaries which can cause pain
HOW TO MANAGE SIDE EFFECTS

Hot flushes:

Avoid hot and spicy foods, caffeinated beverages and alcohol which trigger hot flashes. Stay in a cool environment.

WARNING & PRECAUTIONS
PREGNANCY

ZOLADEX 3.6MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

ZOLADEX 3.6MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

ZOLADEX 3.6MG is not likely to affect you being able to drive or handle any machines.

LIVER

ZOLADEX 3.6MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Cosult your doctor for advice.

ALLERGY

Tell your doctor if you are allergic (hypersensitive) to Goserelin.

HEART DISEASE

ZOLADEX 3.6MG should be used with caution in patients suffering from heart or blood vessel conditions or any other active heart diseases. Consult your doctor for advice.

OTHERS

Inform your doctor if you have or had,

High blood pressure
Problems with passing urine and back, diabetes (in men)
Osteoporosis
INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

Anticonvulsants (used for epilepsy or fits)
Corticosteroids
Quinidine, procainamide, amiodarone and sotalol (used to treat heart problems)
Methadone (used for pain relief and addiction detoxification)
Moxifloxacin (an antibiotic)
Antipsychotics (used for serious mental illnesses)
Oral contraceptives
SYNOPSIS
Drug :   Goserelin
Pharmacological Category :   Antineoplastic Agent, Gonadotropin-Releasing Hormone Agonist
Therapeutic Indication :   Prostate cancer & stage B2 to C, Breast cancer, Endometrial thinning, Endometriosis
Dosage Forms :   Injection
MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ZOLADEX 3.6MG

How long does ZOLADEX 3.6MG take to leave your system?

It takes about 4 weeks (28 days) to dissolve completely. By four weeks, almost all the medicine is gone and has been used by the body.

How is ZOLADEX 3.6MG given?

It is given as a very small pellet injected under the skin (subcutaneously), usually in the tummy area. It releases the drug slowly as it dissolves under the skin.

Can ZOLADEX 3.6MG be used during pregnancy?

It is not recommended if you are trying to pregnant or pregnant. Consult your doctor for advice.

REFERENCES

1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 242.

2. Keith and Bernard. Introduction to endocrinology: The hypothalamic pituitary axis. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page – 1122.

3. Allan Hackshaw, Michael Baum, Tommy Fornander, Bo Nordenskjold, Antonio Nicolucci, Kathryn Monson, Sharon Forsyth, Krystyna Reczko, Ulla Johansson, Helena Fohlin, Miriam Valentini, and Richard Sainsbury. Long-term Effectiveness of Adjuvant Goserelin in Premenopausal Women with Early Breast Cancer. March 4, 2009; [Accessed Jan 11, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650713/

4. AstraZeneca UK Limited, Electronic Medicines Compendium (EMC); [Revised March 2015] [Accessed Jan 11, 2021] https://www.medicines.org.uk/emc/files/pil.1543.pdf

USEFUL DIAGNOSTIC TESTS
Anti Mullerian Hormone
Breast Cancer (CA 15.3/ ER/ PR)
Glycosylated Hemoglobin
Prostate Specific Antigen (Free) PSA
Prostate Specific Antigen (Total) PSA
Testosterone Total
Thyroid Stimulating Hormone
Net Qty
1 N

Ingredient
GOSERELIN 3.6MG

Hsn Code
30049099
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