TROMBOPAG 50 Tablet 7’s

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INTRODUCTION

TROMBOPAG 50 TABLET contains Eltrombopag which belongs to theroup of medicines called Thrombopoietin-receptor agonist. TROMBOPAG 50 TABLET is used to treat immune thrombocytopenia (platelet disorder) in patients aged 1-year/above when other medicines (such as corticosteroids/immunoglobulins) become ineffective to treat the disease.

TROMBOPAG 50 TABLET is also used to treat thrombocytopenia (low platelet count) in adults suffering from hepatitis C (viral) infection. The medicine is also indicated for use to treat low blood counts in adults suffering from severe aplastic anemia (rare blood disorder that occurs due to failure of bone marrow to produce new blood cells).

TROMBOPAG 50 TABLET is not recommended for use in patients allergic to Eltrombopag.

Before taking TROMBOPAG 50 TABLET, inform your doctor if you are at a risk of developing blood clot in veins/arteries, and/or have cancer, obesity, advanced chronic liver disease, and/or kidney problems (such as renal impairment).

TROMBOPAG 50 TABLET isenerally not recommended for use during pregnancy unless it is clearly necessary. Women of childbearing potential should use effective contraceptive measures while in treatment with TROMBOPAG 50 TABLET. It is also not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breastmilk.

TROMBOPAG 50 TABLET is not recommended for use in children (aged below 1-year) suffering from immune thrombocytopenia. It is also not recommended for use in children (aged below 18 years) suffering from low platelet counts due to hepatitis C/severe aplastic anemia. The medicine is advised to be used with caution in elderly patients (aged 65 years/above) after taking the medicine.

The most common side effects of taking TROMBOPAG 50 TABLET are common cold, cough, nausea, vomiting, diarrhea, constipation, and/or hair loss. Consult your doctor if any of these symptoms worsens.

USES OF TROMBOPAG 50 TABLET
Treats immune thrombocytopenia (platelet disorder)
Treats thrombocytopenia in adults suffering from hepatitis C (viral) infection
Treats low blood count in adults suffering from severe aplastic anemia (rare blood disorder caused due to bone marrow failure to produce new blood cells)
HOW TROMBOPAG 50 TABLET WORKS

TROMBOPAG 50 TABLET works by binding and activating thrombopoietin receptor protein (molecules responsible for regulating platelet production) which helps in activating the pathways within the cells to increase production and development of bone marrow progenitor cells (membrane bound units responsible for producing all types of cell in bone marrow) which results in increased production of platelet cells in patients affected with immune thrombocytopenia bleeding disorder associated with/without hepatitis C or severe aplastic anemia.

DIRECTIONS FOR USE

Take TROMBOPAG 50 TABLET as advised by your physician. Swallow the medicine with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

 

SIDE EFFECTS OF TROMBOPAG 50 TABLET
COMMON
Common cold, cough, cold sore, irritation/infection and swelling of sinus/tonsils, itchy/runny/blocked nose, bleeding nose, nasal congestion/sneezing
Loss of appetite, abdominal pain, nausea, vomiting, diarrhea, constipation, bloating,as
Infection in the nose, sinuses, throat, and upper airways
Back pain, bone pain, ear pain, nose/throat pain, toothache
Muscle pain/spasm/weakness
Heavy menstrual period
Sore throat and discomfort while swallowing
Eye problems including dry eye, cataract, spots/deposits in eye, yellowing of white of eye, itchy eye, blurred vision, and/or eye pain
Flu (influenza), pneumonia, infection of lungs, nose, and throat
Mouth problems (including dry mouth, sore mouth, sensitive tongue, bleedingums, mouth ulcers, blisters in mouth), inflammation ofum tissue
Tingling/prickling/numbness sensation  
Decreased skin sensations
Signs of blood clot in deep vein such as pain, swelling, and tenderness in one of your legs
Hematoma (localized swelling filled with blood due to break in blood vessel)
Hot flushes
Toothache
Skin changes including excessive sweating, itching bumpy rash, red spots, and/or changes in appearance of the skin
Hair loss
Signs of proteinuria (protein in urine) such as foamy, frothy, or bubbly-looking urine
High temperature, feeling hot
Weakness, dizziness, drowsiness, tiredness, fever, chills,eneral discomfort
Swelling in hands/feet
Sleeping problems, anxiety, depression, migraine (headache)
Decreased vision
Spinning sensation (vertigo)
Gas
UNCOMMON
Allergic reaction
Interruption of blood to supply to parts of heart
Signs of blood clot in lungs such as sudden shortness of breath, sharp pain in chest, and/or rapid breathing
Blockade in lung artery
Signs of blood clot in a vein such as possible pain, swelling, and/or redness around a vein
Blockage in the bile tract (yellowing of the skin and/or abdominal pain)
Liver damage
Liver injury
Signs of disorder related to the heart and the blood vessels such as heart beating faster, irregular heartbeat, bluish discoloration of the skin, and/or disturbances of heart rhythm
Gout
Mood changes, lack of interest, crying at unexpected times, problems with balance, speech and nerve function, shaking
Painful/abnormal skin sensations
Paralysis on one side of the body
Nerve damage
Dilation/swelling of blood vessels that cause headache
Eye problems such as bleeding of retina
Digestive system problems including frequent bowel movements, food poisoning, blood in stool, vomiting of blood
Rectal bleeding
Sunburn
Redness/swelling around a wound
Bleeding around a catheter (if present) into the skin
Sensation of a foreign body
Signs of kidney problems such as inflammation of the kidney, excessive urination at night, and/or kidney failure
Changes in the shape of the red blood cells
Infection of the skin
Skin changes including skin discoloration, peeling, redness, itching, and/or sweating
Cancer of the rectum and colon
RARE

Stop taking TROMBOPAG 50 TABLET and contact your doctor immediately if you experience any of the following side effects:

Signs of blood clot such as swelling/pain/tenderness in one leg, sudden shortness of breath (associated with sharp pain in the chest), rapid breathing, stomach pain, enlarged abdomen, and/or blood in stools
Signs of liver problems such as yellowing of skin/ whites of the eyes (jaundice), dark-colored urine
Signs of bleeding in the digestive system such as vomiting blood, black tarry stools, and/or blood in stools
HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Take TROMBOPAG 50 TABLET with/just after a meal. Stick to simple meals. Avoid eating oil rich/spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, and drink slowly in between meals. Consult your doctor if the condition worsens.

Diarrhoea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult and inform your doctor if the symptom worsens.

Constipation:

Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (such asoing for a daily walk/ running) and if this does not help, consult and inform your doctor for receiving alternate treatments for constipation.

Dizziness:

Try to rest andet enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.

Headache:

If TROMBOPAG 50 TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usuallyo away after the first week of taking TROMBOPAG 50 TABLET. If it lasts more than a week or becomes severe, then consult and inform your doctor.

Tiredness:

Make sure you take rest and drink plenty of fluids. Avoid/limit the consumption of alcohol. Try to take TROMBOPAG 50 TABLET at a time when you can sit down (or lie down) when the symptoms are at their worst. Avoid driving or using tools or machinery until you feel well.

Dry mouth:

Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult and inform your doctor if the symptomets worse.

WARNING & PRECAUTIONS
PREGNANCY

TROMBOPAG 50 TABLET isenerally not recommended for use during pregnancy unless it is clearly necessary. Women of childbearing potential should use effective contraceptive measures while in treatment with TROMBOPAG 50 TABLET. Consult your doctor before taking the medicine.

 

BREASTFEEDING

TROMBOPAG 50 TABLET is not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breastmilk. Consult your doctor before taking the medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy or less alert after taking TROMBOPAG 50 TABLET.

KIDNEY

TROMBOPAG 50 TABLET should be taken with caution in patients with kidney problems such as renal impairment. Consult your doctor before taking TROMBOPAG 50 TABLET.

LIVER

TROMBOPAG 50 TABLET should be used with caution in patients suffering from advanced chronic liver disease only if necessary, since the medicine may increase the risk of occurrence of side effects/blood clot. Consult your doctor before taking TROMBOPAG 50 TABLET.

ALLERGY

Do not take TROMBOPAG 50 TABLET if you are allergic to Eltrombopag, and/or any other ingredients of this medicine.

OTHERS

Before taking TROMBOPAG 50 TABLET, inform your doctor if you:

Are at a risk of developing blood clot in veins/arteries
Are suffering from cancer
Recently undergone surgery
Had a physical injury
Are obese
Are a smoker
Have cataract (eye lensetting cloudy)
Suffer from another blood condition such as s myelodysplastic syndrome

Use in Pediatrics:

TROMBOPAG 50 TABLET is not recommended for use in children (aged below 1-year) suffering from immune thrombocytopenia (platelet disorder). It is also not recommended for use in children (aged below 18 years) suffering from low platelet counts due to hepatitis C/severe aplastic anemia. Consult your doctor before taking TROMBOPAG 50 TABLET.

Use ineriatrics:

TROMBOPAG 50 TABLET should be used with caution in elderly patients (aged 65-years/above). Consult your doctor before taking TROMBOPAG 50 TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking TROMBOPAG 50 TABLET inform your doctor if you are taking any of the following medicine:

A blood thinner
Antacids (used in indigestion, stomach ulcers/heartburn) Ex. aluminum hydroxide, magnesium carbonate
Statins (used to treat high cholesterol) Ex. atorvastatin, fluvastatin
Lopinavir, ritonavir (medicines used to treat HIV)
Ciclosporin (used to prevent rejection of transplanted organ)
Vitamins and mineral supplements such as iron, calcium, aluminum, magnesium, selenium, and zinc
Methotrexate, topotecan (medicines used to treat cancer)
Corticosteroids (used to provide relief from inflammation) Ex. cortisone, hydrocortisone
Danazol (used to treat endometriosis)
Azathioprine (used for inflammatory conditions)

B. Drug-food interaction:

Avoid taking TROMBOPAG 50 TABLET with dairy foods/drinks since calcium in dairy products may affect the absorption of the medicine and alter its effect.

Overdosage:

If you or anyone else accidentally take too much of TROMBOPAG 50 TABLET, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.

SYNOPSIS
Drug :   Eltrombopag
Pharmacological Category :   Thrombopoietin-receptor agonist
Therapeutic Indication :   Immune thrombocytopenia, thrombocytopenia with hepatitis C virus infection/aplastic anemia          
Dosage Forms :   Tablet
MORE INFORMATION
Keep TROMBOPAG 50 TABLET out of reach of children
Store TROMBOPAG 50 TABLET at room temperature
FAQs ABOUT TROMBOPAG 50 TABLET

What is TROMBOPAG 50 TABLET used for?

TROMBOPAG 50 TABLET is used to treat immune thrombocytopenia (platelet disorder) in patients aged 1-year/above when other medicines (such as corticosteroids/immunoglobulins) become ineffective to treat the disease. It is also used to treat thrombocytopenia (low platelet count) in adults suffering from hepatitis C (viral) infection and/or severe aplastic anemia (rare blood disorder) in affected individuals.

What are the common side effects of taking TROMBOPAG 50 TABLET?

The most common side effects of taking TROMBOPAG 50 TABLET are common cold, cough, nausea, vomiting, diarrhea, constipation, and/or hair loss. Consult your doctor if any of these symptoms worsens.

How TROMBOPAG 50 TABLET works?

TROMBOPAG 50 TABLET works by binding and activating thrombopoietin receptor protein (molecules responsible for regulating platelet production) which helps in activating the pathways within the cells to increase production and development of bone marrow progenitor cells (membrane bound units responsible for producing all types of cell in bone marrow) which results in increased production of platelet cells in patients affected with immune thrombocytopenia bleeding disorder associated with/without hepatitis C or severe aplastic anemia.

How TROMBOPAG 50 TABLET should be taken?

Take TROMBOPAG 50 TABLET as advised by your physician. Swallow the medicines with alass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Can TROMBOPAG 50 TABLET be used in pregnant women?

TROMBOPAG 50 TABLET isenerally not recommended for use during pregnancy unless it is clearly necessary. Women of childbearing potential should use effective contraceptive measures while in treatment with TROMBOPAG 50 TABLET. Consult your doctor before taking the medicine.

REFERENCES

1. Kenneth Kaushansky and Thomas J. Kipps. Hematopoietic Agents:rowth Factors, Minerals, and Vitamins. Hematopoietic Agents:rowth Factors, Minerals, and Vitamins.oodman &ilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 751-767.

2. Thomas Kühne, Paul Imbach. Eltrombopag: an update on the novel, non-peptide thrombopoietin receptor agonist for the treatment of immune thrombocytopenia. Annals of Hematology. Springer Link.  April 2010. [Accessed on 11th May 2022] https://link.springer.com/article/10.1007/s00277-010-0953-x

3. John W Bauman, Carolyn T Vincent, Bin Peng, Mary B Wire, Daphne D Williams, Jung Wook Park. Effect of hepatic or renal impairment on eltrombopag pharmacokinetics. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. May 2011. [Accessed on 11th May 2022] https://pubmed.ncbi.nlm.nih.gov/20663991/

4. Novartis Pharmaceuticals UK Limited. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 11th May 2022] https://www.medicines.org.uk/emc/files/pil.7819.pdf

USEFUL DIAGNOSTIC TESTS
Blood smear test
VIDEOS
Eltrombopag Tablet – Drug Information

Eltrombopag Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage

PRODUCT DETAILS
Country Of Origin
India

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TROMBOPAG 50 Tablet 7's

US$97.00US$164.00 (-41%)

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