INTRODUCTION
THROMBOHEPEL contains Heparin which belongs to theroup of medicines called Anticoagulants. It is used to treat varicose syndromes and their complications, phlebothrombosis (blood clot in veins), thrombophlebitis (inflammation of a vein due to blood clot), superficial periphlebitis (inflammation of the superficial veins), varicose ulcers, post-surgical varicose veins, after saphenectomy (removal of a damaged vein).
THROMBOHEPEL can also be used in traumas and injuries, localized oedemas, subcutaneous hematoma (collection of blood under the skin) alone or in combination with systemic therapy.
A blood clot or thrombus is ael-like collection of blood that form in arteries or veins when blood changes from liquid to partially solid form. Your doctor might want you to take certain blood tests prior to the treatment.
Before applying THROMBOHEPEL inform your doctor if you have bleeding, open wounds or mucosae, sites of infection, or hemorrhagic phenomena (excessive bleeding). There is a lack of data on the use of THROMBOHEPEL in pregnant and breastfeeding women. Consult with your doctor before using.
THROMBOHEPEL is not recommended for use in children and adolescents below 18 years of age. The most common side effects of applying THROMBOHEPEL are burning, redness, itching and irritation at application site. Consult your doctor if symptoms do not show improvement.
USES OF THROMBOHEPEL
Treats,
Varicose syndromes and their complications, varicose ulcers
Phlebothrombosis (blood clot in veins of the leg)
Thrombophlebitis (inflammation of a vein in the leg)
Post-surgical varicose veins
Saphenectomy (removal of a damaged vein)
Traumas and injuries
Localized oedemas
Subcutaneous hematoma (collection of blood under the skin)
HOW THROMBOHEPEL WORKS
THROMBOHEPEL binds to the antithrombin (an enzyme present in the clotting system) which in turn inhibits several clotting factors such as factor Xa, factor IIa. This inactivation of thrombin prevents the formation of clots and prolongs the clotting time of blood.
DIRECTIONS FOR USE
Apply THROMBOHEPEL as advised by your physician. It is for external use only. Apply the medicine to the affected area and massageently. Wash your hands before and after the application of the medicine. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
SIDE EFFECTS OF THROMBOHEPEL
COMMON
Skin rashes
Redness
Itching and burning sensation on the skin
Rough patches on the skin
RARE
Stop applying THROMBOHEPEL and contact your doctor immediately if you experience any of the following side effects:
Sensitization phenomenon (repeated exposure to the same drug increases specific behavioural, physiological responses to it)
HOW TO MANAGE SIDE EFFECTS
Itchy skin:
Hot water makes your skin irritated, so avoid taking hot showers. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. To soothe and hydrate irritated skin, apply moisturizers. Contact your doctor if the itching worsens.
WARNING & PRECAUTIONS
PREGNANCY
There is a lack of data on the use of THROMBOHEPEL in pregnant women. Consult with your doctor before using.
BREASTFEEDING
There is a lack of data on the use of THROMBOHEPEL in breastfeeding women. Consult with your doctor before using.
DRIVING AND USING MACHINES
THROMBOHEPEL does not affect your ability to drive or use machines.
ALLERGY
Do not apply THROMBOHEPEL if you are allergic to Heparin or any other ingredients of this medicine.
OTHERS
THROMBOHEPEL is not recommended for use if you:
Have hypersensitivity to the medicine
Before applying THROMBOHEPEL, inform your doctor if you have:
Bleeding, open wounds or mucosae
Sites of infection
Hemorrhagic phenomena (excessive bleeding)
Use in pediatrics:
THROMBOHEPELis not recommended for use in children and adolescents below 18 years of age as safety and effectiveness have not been established yet. Consult with your child’s doctor before using THROMBOHEPEL for your child.
Use ineriatrics:
There is no information the use of THROMBOHEPEL in elderly patients. Ask for your doctor’s advice before using.
INTERACTIONS
A. Drug – Drug interactions:
Before applying THROMBOHEPEL, inform your doctor if you are taking any of the following medicine:
Other oral anticoagulants used to prevent blood clots (Ex. warfarin)
Overdosage:
If you or anyone else accidentally ingests or applies too much of THROMBOHEPEL, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
Drug : Heparin
Pharmacological Category : Anticoagulant
Therapeutic Indication : Blood clots
Dosage Forms : el, Injection, Solution, Topical solution
MORE INFORMATION
Keep THROMBOHEPEL out of reach of children
Store THROMBOHEPEL at room temperature below 25°C
FAQs ABOUT THROMBOHEPEL
Can THROMBOHEPEL be used in children?
THROMBOHEPELis not recommended for use in children and adolescents below 18 years of age as safety and effectiveness have not been established yet. Consult your child’s doctor before using THROMBOHEPEL for your child.
What is THROMBOHEPEL used for?
THROMBOHEPEL is used to treat varicose syndromes and their complications, blood clots in veins of the leg, inflammation of veins in the leg, varicose ulcers, post-surgical varicose veins, after removal of the damaged vein, traumas and injuries, localized oedemas, subcutaneous hematoma
Can THROMBOHEPEL be used in pregnant women?
Inform your doctor if you are pregnant or planning to have a baby before applying THROMBOHEPELas safety and effectiveness has not been established yet. Consult your doctor before applying it.
Can THROMBOHEPEL cause any side effects?
THROMBOHEPEL can cause itching, burning, redness and irritation at the application site in certain patients. Consult your doctor if the symptoms worsen
How does THROMBOHEPEL work?
THROMBOHEPEL binds to the antithrombin which in turn inhibits several clotting factors (factor Xa, factor IIa). Thus, by inactivating the thrombin it prevents the formation of clots and prolongs the clotting time of blood.
REFERENCES
1. KD Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis. Essentials of medical pharmacology. Eighth Edition. 2019. Page –663-664.
2. Vikas Saini, Tanvir Samra, Nitin Ahuja, Sameer Sethi. A prospective randomized study to evaluate safety and efficacy of heparin topical solution (1000 IU/ml) compared to heparin topicalel (200 IU/g) in prevention of infusion-associated phlebitis. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed Central. November 2018. [Accessed on 11th August 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364337/
3. Cesare Vecchio, Anna Frisinghelli. Topically applied heparins for the treatment of vascular disorders: a comprehensive review. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.govl.. [Accessed on 11th August 2022]. https://pubmed.ncbi.nlm.nih.gov/18783299/
4. A.Menarini Manufacturing Logistics and Services s. r.l. Heparin. [Revised in April 2022] [Accessed on 11th August 2022] https://myhealthbox.eu/en/view/1713833/12bf9dc32c5347af6f251ea29579737d/leaflet
5. Prevago Healthcare. Thrombohepel (Heparin). [Accessed on 11th August 2022]. https://www.prevegohealthcare.com/product-page/thrombohep-gel
6. Leeford Healthcare. Aparin (Heparin). [Accessed on 11th August 2022]. https://www.leeford.in/product/1244/aparin
7. Heparin. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 11th August 2022] https://cdscoonline.gov.in/CDSCO/Drugs
Drug bank. Heparin. [Accessed on 11th August 2022]. https://go.drugbank.com/drugs/DB01109
USEFUL DIAGNOSTIC TESTS
Blood tests
Prothrombin Time
PRODUCT DETAILS
Country Of Origin
India
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