ROZUTIN CLA 10 Capsule 10’s

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INTRODUCTION

ROZUTIN CLA 10 CAPSULE is a combination of Aspirin, Clopidogrel and Rosuvastatin which belongs to theroup of medicines called Antiplatelets and HMG-CoA reductase inhibitors respectively. ROZUTIN CLA 10 CAPSULE is indicated for the treatment of acute coronary syndrome, myocardial infarction (heart attack), angina (chest pain) or stroke (reduced blood supply to brain leading to brain death) that were caused due to clot or plaque formation in the blood vessels supplying the heart.

Acute coronary syndrome is a heart condition caused by plaque rupture or clot formation in the coronary arteries. Symptoms include heart attack, chest pressure or pain while at rest, shortness of breath and sweating.

Along treatment with ROZUTIN CLA 10 CAPSULE follow a healthy low-fat diet as advised by doctor to achieve better results.

Avoid drinking alcohol during the therapy, as it could increase the risk of bleeding in theastrointestinal tract. ROZUTIN CLA 10 CAPSULE is not recommended for use in patients having severe liver, kidney or heart disease. Consult your doctor before taking this medicine.

ROZUTIN CLA 10 CAPSULE isenerally not recommended for use in pregnant or breastfeeding women and in children (below 18 years). Consult your doctor for an alternative therapy.

The most common side effects of taking ROZUTIN CLA 10 CAPSULE are increased bleeding tendency, nausea, indigestion, diarrhea, stomach pain, constipation, muscle pain, dizziness and headache. Contact your doctor if any of these symptoms worsen.

USES OF ROZUTIN CLA 10 CAPSULE
Treats acute coronary syndrome 
Treats myocardial infarction
Treats angina
Treats stroke
HOW ROZUTIN CLA 10 CAPSULE WORKS

ROZUTIN CLA 10 CAPSULE effectively improves cardiac function and reduces the risk of heart problems, where clopidogrel acts by inhibiting platelet aggregation in the coronary arteries, aspirin acts by blocking the actions of an enzyme called cyclo-oxygenase 1 which is believed to be responsible for catalyzing the synthesis of platelets and rosuvastatin acts by inhibiting the action of an enzyme called HMG-CoA reductase, which is required to catalyze the formation of cholesterol, thus preventing clot or plaque formation in the coronary arteries leading to an uninterrupted supply of oxygen and blood to the heart.

DIRECTIONS FOR USE

Take ROZUTIN CLA 10 CAPSULE as advised by your physician. Swallow ROZUTIN CLA 10 CAPSULE with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ROZUTIN CLA 10 CAPSULE
COMMON
Increased bleeding or bruising
Indigestion, diarrhea, stomach pain, nausea, constipation
Bleeding in theut
Diabetes (high bloodlucose)
Dizziness and headache
Muscle cramps or pain
Weakness or lack of energy
Epistaxis (bleeding from the nose)
UNCOMMON
Runny nose
Skin rash, itching or skin reactions
Breathing difficulty
Stomach ulcer, vomiting
Excessiveas in stomach or intestine
Tingling or numbness sensation
RARE
Signs of decreased platelet count (easy bleeding or bruising)
Enlarged breasts in men (gynecomastia)
Vertigo (spinning sensation)
Lupus-like disease syndrome (including rash, joint disorders and effects on blood cells)
Aplastic anemia
Intracranial hemorrhage (bleeding in the brain)

Stop taking ROZUTIN CLA 10 CAPSULE and contact your doctor immediately if you experience any of the following side effects:

Severe allergic reactions (such as skin rash, itching, swelling of the face, lips, throat and neck, difficulty in breathing or swallowing)
Thrombotic Thrombocytopenic Purpura (a blood disorder that causes blood clots in capillaries throughout the body)
Severe skin disorders with fever (Ex. Lyell’s syndrome, Steven-Johnsons syndrome, erythema nodosum, erythema multiforme)
Symptoms of pancreatitis (such as moderate to severe abdominal pain, nausea, vomiting, fever, rapid heart rate)
Jaundice (yellowing of eyes, skin and urine with fever)
Rhabdomyolysis (muscle rupture)
Unusual bleeding (such as blood in vomit or urine, coughing up blood, black stools, purple spots under the skin)
Flu-like symptoms (fever, cough, sore throat, headache and extreme tiredness)
Breathing difficulties (Ex. bronchospasm, asthma attack)
Hemorrhagic vasculitis (inflammation of the blood vessels with bleeding)
Abnormal heavy or prolonged menstrual periods
HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try to take ROZUTIN CLA 10 CAPSULE with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax.et enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Constipation:

Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS
PREGNANCY

ROZUTIN CLA 10 CAPSULE is not recommended for use in pregnant women. However, consult your doctor before taking ROZUTIN CLA 10 CAPSULE. Women of child-bearing potential should use suitable contraceptive method to avoid pregnancy while taking ROZUTIN CLA 10 CAPSULE.

BREASTFEEDING

ROZUTIN CLA 10 CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

DRIVING AND USING MACHINES

ROZUTIN CLA 10 CAPSULE does not affect your ability to drive or operate machines. However, if you experience dizziness during treatment with ROZUTIN CLA 10 CAPSULE, do not drive or operate any machines. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

ALCOHOL

Avoid consumption of alcohol while taking ROZUTIN CLA 10 CAPSULE as it may increase the risk of stomach bleeding and aggravate your existing condition.

KIDNEY

ROZUTIN CLA 10 CAPSULE is not recommended for use in patients having moderate-to-severe kidney disease and ROZUTIN CLA 10 CAPSULE should be used with caution in patients with kidney problems. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

LIVER

ROZUTIN CLA 10 CAPSULE is not recommended for use in patients having severe liver disease and active liver disease (including persistent elevations of serum transaminases exceeding three times the upper limit) and ROZUTIN CLA 10 CAPSULE should be used with caution in patients with history of liver disease. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

ALLERGY

Do not take ROZUTIN CLA 10 CAPSULE if you are allergic to Clopidogrel, Rosuvastatin, Aspirin or prostaglandin synthetase inhibitors (Ex. naproxen, ibuprofen, mefenamic acid and indomethacin).

LUNGS

ROZUTIN CLA 10 CAPSULE should be used with caution in patients with interstitial lung disease or severe respiratory failure. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

HEART DISEASE

ROZUTIN CLA 10 CAPSULE is not recommended for use in patients with recent ischemic stroke. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

OTHERS

ROZUTIN CLA 10 CAPSULE is not recommended for use if you:

Have or had any repeated or unexplained muscle pains
Have family history of hereditary muscular disorders
Have family history of muscle problems following treatment with cholesterol-lowering medicines
Have an underactive thyroidland
Haveastrointestinal problems (such as peptic ulcer or bleeding in theut)
Have bleeding disorders (Ex. bleeding in the brain, hemophilia or others)
Have thrombocytopenia (decreased platelet count)
Haveout
Have lactose intolerance
Have diabetes
Have dehydration
Have menorrhagia (abnormally heavy bleeding during menstruation)
Are alcoholic

Before taking ROZUTIN CLA 10 CAPSULE, inform your doctor if you have:

Upcoming planned surgery (including dental surgery)

Use in pediatrics:

ROZUTIN CLA 10 CAPSULE is strictly not recommended for use in children under 6 years of age andenerally not recommended for use in children and adolescents (under 18 years of age) unless prescribed by your physician due to increased risk of bleeding. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

Use ineriatrics:

ROZUTIN CLA 10 CAPSULE should be used with caution in elderly patients (aged 70 years or above) because of increased risk ofastro-intestinal bleeding and perforation when used for prolonged duration (if prolonged therapy is essential, patients should be reviewed regularly). Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

INTERACTIONS

A. Drug-Drug interactions:

Before taking ROZUTIN CLA 10 CAPSULE inform to your doctor, if you are taking any of these medicines:

Other anticoagulants (used for blood thinning) Ex. warfarin, coumarin, heparin, phenindione
Other cholesterol-lowering medicines (Ex. clofibrate,emfibrozil, fenofibrate, ezetimibe)
Other non-steroidal anti-inflammatory drugs (Ex. ibuprofen, paracetamol)
Medicines used to treat HIV infection (Ex. ritonavir with lopinavir and/or atazanavir or sofosbuvir with velpatasvir and voxilaprevir)
Selective serotonin reuptake inhibitors (used to treat depression) Ex. fluoxetine, sertraline, paroxetine or fluvoxamine 
Medicines used to treat stomach ulcers such as antacids (Ex. aluminium hydroxide, magnesium hydroxide) and proton-pump inhibitors (Ex. omeprazole or esomeprazole)
Medicines used during percutaneous coronary intervention (Ex. abciximab, eptifibatide and tirofiban)
Antibiotics (used to treat bacterial infections) such as macrolides (Ex. azithromycin, erythromycin, roxithromycin and clarithromycin) or fusidic acid
Medicines used to treat epilepsy (Ex. phenytoin, valproic acid)
Medicines used to treat diabetes (Ex. insulin,lipizide,limepiride)
Ciclosporin or tacrolimus (used to preventraft rejection or treat auto-immune disease)
Nicotinic acid (used to treat vitamin b3 deficiency)
Azole antifungal agents (used to treat fungal infection) Ex. clotrimazole, fluconazole
Methotrexate (used to treat cancer or other auto-immune diseases)
Digoxin (used to treat abnormal heart rate)
Darolutamide (used to treat prostate cancer)
Regorafenib (used to treat colon or rectal cancer)
Probenecid or sulfinpyrazone (used to treatout)
Dipyridamole (an antiplatelet medicine)
Lithium (used to treat metal illness)
Corticosteroids (used to treat pain and inflammation) Ex. prednisolone, dexamethasone
Acetazolamide (used to treat or prevent altitude sickness)
Mifepristone (abortion pill)
Metoclopramide (used to treat vomiting)

Overdosage:

If you or anyone else take too much of ROZUTIN CLA 10 CAPSULE, contact your doctor immediately oro to a hospital straight away. Overdosage symptoms of ROZUTIN CLA 10 CAPSULE might include increased bleeding, confusion, disorientation, coma, convulsions, vomiting, tinnitus (ringing in the ears), vertigo (spinning sensation), sweating, warm extremities with bounding pulses, increased respiratory rate and hyperventilation.

SYNOPSIS
Drug :   Aspirin, Clopidogrel, Rosuvastatin
Pharmacological Category :  

Antiplatelets, HMG-CoA reductase inhibitors

Therapeutic Indication :  

Acute coronary syndrome, Myocardial infarction, Angina, Stroke           

Dosage Forms :   Tablet, Capsule
MORE INFORMATION
Keep ROZUTIN CLA 10 CAPSULE out of reach of children
Store at room temperature
FAQs ABOUT ROZUTIN CLA 10 CAPSULE

Can ROZUTIN CLA 10 CAPSULE make me bleed more?

Yes. ROZUTIN CLA 10 CAPSULE can increase your tendency to bleed and therefore it should be used with caution in patients having bleeding disorders like hemophilia, bleeding in theut, brain or under the skin or others. While taking ROZUTIN CLA 10 CAPSULE if you experience any symptoms like blood in vomit or urine, coughing up blood, black stools or purple spots under the skin, contact your doctor immediately as it could be a sign of severe internal bleeding.

Can ROZUTIN CLA 10 CAPSULE be taken during periods?

ROZUTIN CLA 10 CAPSULEenerally can increase your tendency to bleed and if taken during periods, it may cause heavy menstrual bleeding. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE. Your doctor might either ask you to discontinue the treatment with ROZUTIN CLA 10 CAPSULE for some time or may suggest an alternative therapy to improve your disease condition.

Can I continue to take ROZUTIN CLA 10 CAPSULE before any planned surgeries?

No. Avoid taking ROZUTIN CLA 10 CAPSULE if you areoing to undergo any surgery (including dental surgery) because this medicine can make you bleed more than usual. Your doctor might either ask you to discontinue the treatment with ROZUTIN CLA 10 CAPSULE for some time or may suggest an alternative therapy to improve your disease condition.

Can ROZUTIN CLA 10 CAPSULE be used in children?

No. ROZUTIN CLA 10 CAPSULE is not recommended for use in children and adolescents (under 18 years) unless prescribed by your physician. ROZUTIN CLA 10 CAPSULE is strictly not recommended for use in children aged less than 6 years due to risk of increased side effects. Consult your doctor before taking ROZUTIN CLA 10 CAPSULE.

Can I try toet pregnant while taking ROZUTIN CLA 10 CAPSULE?

No. ROZUTIN CLA 10 CAPSULE should be discontinued from use if you are trying toet pregnant because, it may cause severe abnormalities to therowing fetus. Also, it is advised that women of child-bearing potential should use suitable contraceptive method to avoid pregnancy while taking ROZUTIN CLA 10 CAPSULE.

Can I consume alcohol while taking ROZUTIN CLA 10 CAPSULE?

No. Avoid consumption of alcohol while taking ROZUTIN CLA 10 CAPSULE as it could aggravate your existing disease condition and increase the risk of bleeding. Before taking ROZUTIN CLA 10 CAPSULE inform your doctor if you are alcoholic or have history of alcohol abuse.

REFERENCES

1. KD. Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis and Hypolipidemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page – 629-633 & 636-638.

2. Jeffery I. Weitz. Blood coagulation and Anticoagulant, Fibrinolytic and Antiplatelet Drugs. Thomas P. Bersot. Drug therapy for hypercholesterolemia and dyslipidemia.oodman &ilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 868-870 & 892-898.

3.erald. Briggs and Roger K. Freeman. A. C. & R. A referenceuide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 888-891, 288-298 & 3463-3465.

4. Susan Smyth. Early Use of Rosuvastatin in Acute Coronary Syndromes: Targeting Platelet-Leukocyte Interactions. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in March 2017] [Accessed on 7th October 2021] https://www.clinicaltrials.gov/ct2/show/study/NCT01241903

5. Michael J. Lim, Frederick A. Spencer, Joel M.ore, Omar H. Dabbous, Giancarlo Agnelli, Eva M. Kline-Rogers, Donna DiBenedetto, Kim A. Eagle, Rajendra H. Mehta. Impact of combined pharmacologic treatment with clopidogrel and a statin on outcomes of patients with non-ST-segment elevation acute coronary syndromes: perspectives from a large multinational registry. European Heart Journal. Oxford Academic. February 2005. [Accessed on 7th October 2021] https://academic.oup.com/eurheartj/article/26/11/1063/560931

6. Charles H Hennekens  Danielle Hollar, Arthur S Agatston. Aspirin and Statins to Decrease Risks of Cardiovascular Disease – The Need for Wider Utilization. US Cardiology reviews. 2004. [Accessed on 7th October 2021] https://www.uscjournal.com/articles/aspirin-and-statins-decrease-risks-cardiovascular-disease-need-wider-utilization-0

7. Travis R. Sexton, Eric L. Wallace, Tracy E. Macaulay, Richard J. Charnigo, Virgilio Evangelista, Charles L. Campbell, Alison L. Bailey and Susan S. Smyth. The effect of rosuvastatin on thromboinflammation in the setting of acute coronary syndrome. NCBI; PMC US National Library of Medicine, National Institute of Health. October 2014. [Accessed on 7th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320305/

8. Ke An, Rong Huang, Sai Tian, Danuo, Jiaqi Wang, Hongyan Lin and Shaohua Wang. Statins significantly reduce mortality in patients receiving clopidogrel without affecting platelet activation and aggregation: a systematic review and meta-analysis. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2019. [Accessed on 7th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533696/

9. P. Maggi, G. V. De Socio, S. Cicalini, M. D’Abbraccio, G. Dettorre, A. Di Biagio, C. Martinelli, G. Nunnari, S. Rusconi, L. Sighinolfi, V. Spagnuolo and N. Squillace. Statins and aspirin in the prevention of cardiovascular disease among HIV-positive patients between controversies and unmet needs: review of the literature and suggestions for a friendly use. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2019. [Accessed on 7th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534832/

10. Torrent Pharmaceuticals Ltd. Unistarold / Rozucorold. Torrentian.com. [Revised in March 2021]. [Accessed on 7th October 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2934.pdf

11. Cipla Ltd. Rosulipold Capsules (Rosuvastatin calcium + Clopidogrel + Aspirin). Ciplamed.com. [Revised in January 2019]. [Accessed on 7th October 2021] https://ciplamed.com/content/rosulip-gold-capsules

USEFUL DIAGNOSTIC TESTS
Electrocardiogram
Kidney function test
Liver function test
Complete blood count
VIDEOS
Aspirin+Clopidogrel+Rosuvastatin Capsule – Drug Information

Aspirin+Clopidogrel+Rosuvastatin Capsule : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage

PRODUCT DETAILS
Net Qty
1 N
Item Weight
17.5
Ingredient
ASPIRIN 75 mg+CLOPIDOGREL 75 mg+ROSUVASTATIN 10 mg
Hsn Code
30049099
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Additional information

Weight 17.5 g

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ROZUTIN CLA 10 Capsule 10's

US$18.00US$25.00 (-28%)

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