RIVOXAMAC 15 Tablet 10’s

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INTRODUCTION

RIVOXAMAC 15 TABLET contains Rivaroxaban, which belongs to theroup of medicines called Antithrombotic agents. It is used to treat deep vein thrombosis (DVT), pulmonary embolism (PE), and venous thromboembolism (VTE). It is also used to reduce the risk of stroke, systemic embolism in nonvalvular atrial fibrillation, recurrence of DVT or PE, major cardiovascular events in patients with coronary artery disease (CAD), and major thrombotic vascular events in patients with peripheral artery disease (PAD). Venous thromboembolism is a condition that occurs due to clot formation in the venous circulation.

It can also be used for THE prevention of DVT in patients undergoing knee or hip replacement surgery, VTE in acutely ill medical patients, and thrombosis in children (older than 2 years) with congenital heart disease post the Fontan procedure.

Before taking RIVOXAMAC 15 TABLET, inform your doctor if you have any liver, kidney, or bleeding problems or antiphospholipid syndrome. RIVOXAMAC 15 TABLET is not recommended for use in pregnant or breast-feeding women, so consult your doctor before taking it.

RIVOXAMAC 15 TABLET is not studied and is not recommended in children less than 6 months of age who were less than 37 weeks ofrowth at birth, had less than 10 days of oral feeding, or weigh less than 2.6 kg. RIVOXAMAC 15 TABLET should be used with caution in elderly patients (65 years or older). Consult your doctor before taking it.

The most common side effects of taking RIVOXAMAC 15 TABLET are bleeding, pain and swelling in the limbs, fever, stomach pain, indigestion, nausea, vomiting, constipation, diarrhea, low blood pressure (feeling dizzy or fainting when standing up), weakness, tiredness, headache, dizziness, rash, and itchy skin. Contact your doctor if any of your symptoms worsen.

USES OF RIVOXAMAC 15 TABLET

It is used:

Treats deep vein thrombosis (DVT), pulmonary embolism (PE), venous thromboembolism (VTE)
Reduces the risk of stroke, systemic embolism in nonvalvular atrial fibrillation, recurrence of DVT or PE, major cardiovascular events in patients with coronary artery disease (CAD), and major thrombotic vascular conditions in patients with peripheral artery disease (PAD)
Prevention of DVT in patients undergoing knee or hip replacement surgery, VTE in acutely ill medical patients, and thrombosis in children (2 years and older) with congenital heart disease post the Fontan procedure
HOW RIVOXAMAC 15 TABLET WORKS

RIVOXAMAC 15 TABLET works by competitively inhibiting factor Xa (a clotting factor) and preventing the progression of the coagulation cascade through the final common pathway, thus preventing thrombineneration.

DIRECTIONS FOR USE

Take RIVOXAMAC 15 TABLET as advised by your physician. Swallow the medicine with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking RIVOXAMAC 15 TABLET unless your doctor advises.

SIDE EFFECTS OF RIVOXAMAC 15 TABLET
COMMON
Decrease in red blood cells (pale skin, weakness, or breathlessness)
Bleeding in the stomach or intestine, urogenital bleeding (including blood in the urine and heavy menstrual bleeding), nosebleed, bleeding in theum
Bleeding into the eye (including from the whites of the eyes)
Hematoma, bruising (bleeding into tissue or a cavity of the body)
Coughing up blood
Bleeding from or under the skin
Bleeding after an operation
Oozing of blood or fluid from surgical injury
Impaired kidney function (may be seen in tests performed by your doctor)
Pain and swelling in the limbs
Fever
Stomach pain, indigestion, nausea, vomiting, constipation, diarrhea
Low blood pressure (feeling dizzy or fainting when standing up)
Weakness, tiredness, headache, dizziness
Rash, itchy skin
UNCOMMON
Bleeding into the brain or inside the skull, or into a joint (pain and swelling)
Low number of platelets
Allergic reactions including skin reactions
Fainting
Feeling unwell
Rapid heartbeat
Dry mouth
Hives
RARE
Bleeding into a muscle
Decreased bile flow, inflamed liver including liver injury
Yellowing of the skin and eye
Localized swelling
Accumulation of blood in theroin as a complication of the cardiac procedure where a catheter is inserted in your leg artery

Stop taking RIVOXAMAC 15 TABLET and contact your doctor immediately if you experience any of the following side effects:

Bleeding inside brain (headache, one-sided weakness, vomiting, seizures, decreased level of consciousness, neck stiffness); long or excessive bleeding; abnormal weakness, tiredness, paleness, dizziness, unexplained swelling, breathlessness, chest pain; frequent nose bleeds; abnormal bleeding from theums; menstrual bleeding that is heavier than normal or vaginal bleeding; bleeding that is severe or uncontrollable; red, pink or brown urine; bright red or black tar-like stools; cough up blood or blood clots; vomit blood or your vomit looks like “coffeerounds”; pain, swelling, or new drainage at wound sites
Severe skin reactions (spreading intense skin rash, blisters or mucosal lesions in the mouth or eyes, a drug reaction that causes rash, fever, inflammation of internal organs, blood abnormalities and systemic illness)
Severe allergic reaction (swelling of the face, lips, mouth, tongue, or throat; trouble swallowing; hives and breathing difficulties; sudden drop in blood pressure)
Spinal or epidural blood clots
Back pain
Muscle weakness (legs and feet)
Tingling
Bowel or bladder incontinence
Numbness
HOW TO MANAGE SIDE EFFECTS

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.

Nausea:

Take RIVOXAMAC 15 TABLET with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.

Vomiting:

Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it – you do not need to eat or avoid any specific foods. Do not take any medicine other than RIVOXAMAC 15 TABLET without asking your doctor.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine other than RIVOXAMAC 15 TABLET without consulting your doctor.

Headache:

Drink ample amount of water.et adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache.

Dizziness:

Lie down until dizziness isone, thenet up slowly. Move slowly and carefully, do not hurry.et adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs.

WARNING & PRECAUTIONS
PREGNANCY

RIVOXAMAC 15 TABLET is not recommended for use in pregnant women as it not known if it causes any harm to the unborn baby. Consult your doctor before taking it.

BREASTFEEDING

RIVOXAMAC 15 TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy after taking RIVOXAMAC 15 TABLET.

KIDNEY

RIVOXAMAC 15 TABLET should be taken with caution in adults with severe kidney disease and children with moderate or severe kidney disease. Consult your doctor before taking RIVOXAMAC 15 TABLET.

LIVER

RIVOXAMAC 15 TABLET is not recommended for use in patients with liver disease which leads to an increased risk of bleeding. Consult your doctor before taking RIVOXAMAC 15 TABLET.

ALLERGY

Do not take RIVOXAMAC 15 TABLET if you are allergic to Rivaroxaban or any of the other ingredients of this medicine.

LUNGS

RIVOXAMAC 15 TABLET should be used with caution in patients with lung disease where the bronchi are widened and filled with pus, or those with previous bleeding from the lung. Consult your doctor before taking RIVOXAMAC 15 TABLET.

HEART DISEASE

RIVOXAMAC 15 TABLET is not recommended for use in patients with acute coronary syndrome, coronary artery disease, or peripheral artery disease. RIVOXAMAC 15 TABLET should be taken with caution in patients with very high or unstable blood pressure which is not controlled by medicines, prosthetic heart valve, or coronary artery disease with severe symptomatic heart failure. Consult your doctor before taking RIVOXAMAC 15 TABLET.

OTHERS

RIVOXAMAC 15 TABLET is not recommended for use if you:

Are bleeding excessively
Have a disease or condition in an organ of the body that increases the risk of serious bleeding (Ex. stomach ulcer, injury or bleeding in the brain, recent operation of the brain or eyes)
Had stroke (previously had a bleeding or a blood clot in your brain)
Had lacunar stroke (blockage of the small arteries providing blood to the brain’s deep tissues) or ischemic, nonlacunar stroke (blood clot in your brain) in the previous month

Before taking RIVOXAMAC 15 TABLET, inform your doctor if you:

Have or had bleeding problems
Have antiphospholipid syndrome (immunity disorder that causes an increased risk of blood clots)
Have diseases of your stomach or bowel that might result in bleeding (Ex. inflammation of the bowels, stomach, or food pipe) or tumours in the stomach, bowels,enital tract, or urinary tract)
Have retinopathy (problem with the blood vessels in the back of your eyes)
Need to have an operation
Weigh less than 60 kg

Use in pediatrics:

RIVOXAMAC 15 TABLET is not studied and is not recommended for use in children less than 6 months of age who were less than 37 weeks ofrowth at birth, had less than 10 days of oral feeding, or weigh 2.6 kg. RIVOXAMAC 15 TABLET is not recommended for use in children with moderate to severe kidney disease. Consult your doctor before taking RIVOXAMAC 15 TABLET.

Use ineriatrics:

RIVOXAMAC 15 TABLET should be used with caution in elderly patients (aged above 75 years). Consult your doctor before taking RIVOXAMAC 15 TABLET.

INTERACTIONS

A. Drug – Drug interactions:

Before taking RIVOXAMAC 15 TABLET, inform your doctor if you are taking any of the following medicine:

Medicines used for fungal infections (Ex. fluconazole, itraconazole, voriconazole, posaconazole), unless they are used on the skin
Ketoconazole (used to treat Cushing’s syndrome)
Medicines used for bacterial infections (Ex. clarithromycin, erythromycin, rifampicin)
Medicines used for HIV infection (Ex. ritonavir, indinavir)
Other medicines used to reduce blood clotting (Ex. enoxaparin, clopidogrel, warfarin, apixaban, heparin, acenocoumarol, prasugrel, ticagrelor)
Medicines used to treat inflammation and pain (Ex. naproxen, acetylsalicylic acid)
Dronedarone (used to treat abnormal heartbeat)
Medicines used to treat depression (Ex. citalopram, fluoxetine, venlafaxine, duloxetine, St. John’s wort)
Medicines used to treat fits (Ex. carbamazepine, phenytoin, phenobarbital)

Overdosage:

If you or anyone else accidentally take too much of RIVOXAMAC 15 TABLET, consult your doctor immediately or visit the nearby hospital. Symptom of overdose include bleeding.

SYNOPSIS
Drug :   Rivaroxaban
Pharmacological Category :   Factor Xa inhibitor
Therapeutic Indication :   Treatment and prevention of deep vein thrombosis (DVT), pulmonary embolism (PE), and venous thromboembolism (VTE)
Dosage Forms :   Tablet
MORE INFORMATION
Keep RIVOXAMAC 15 TABLET out of reach from children
Store RIVOXAMAC 15 TABLET between 15-30°C
FAQs ABOUT RIVOXAMAC 15 TABLET

Can I take RIVOXAMAC 15 TABLET before surgery?

It is very important to take RIVOXAMAC 15 TABLET before and after any surgery (including a catheter or injection into your spinal cord) exactly at the times advised by your doctor. Inform your doctor immediately if youet numbness or weakness in your legs or problems with your bowels or bladder after the end of anesthesia, because urgent care is required.

Can RIVOXAMAC 15 TABLET be crushed?

If you have difficulty swallowing RIVOXAMAC 15 TABLET whole, ask your doctor about other ways to take RIVOXAMAC 15 TABLET. RIVOXAMAC 15 TABLET may be crushed and mixed with water or a soft food such as apple puree just before you take it. If required, your doctor mayive you the crushed medicine through a stomach tube.

What if I forget to take a dose of RIVOXAMAC 15 TABLET?

If you forget to take a dose of RIVOXAMAC 15 TABLET, take it as soon as you remember and continue the treatment as per your prescribed schedule. Do not take RIVOXAMAC 15 TABLET twice to make up for a forgotten dose.

Can RIVOXAMAC 15 TABLET be used in pregnancy?

Before taking RIVOXAMAC 15 TABLET, inform your doctor if you are pregnant or planning to become pregnant, as it may increase the risk of bleeding in you (uterine) or in your unborn baby. It is not known if RIVOXAMAC 15 TABLET can harm your unborn baby. Tell your doctor immediately if you become pregnant during treatment with RIVOXAMAC 15 TABLET. If you take RIVOXAMAC 15 TABLET during pregnancy, inform your doctor right away if you see any signs or symptoms of bleeding or blood loss.

What if I spit or vomit a dose of RIVOXAMAC 15 TABLET?

If you spit up or vomit a dose of RIVOXAMAC 15 TABLET less than 30 minutes after you have taken it, take a new dose. If you spit RIVOXAMAC 15 TABLET up more than 30 minutes after you took it, do not take a new dose and take the next one at the usual time. Contact the doctor if you repeatedly spit up or vomit RIVOXAMAC 15 TABLET doses.

Can RIVOXAMAC 15 TABLET be used in infants?

RIVOXAMAC 15 TABLET is not studied and is not recommended in children less than 6 months of age who were less than 37 weeks ofrowth at birth, had less than 10 days of oral feeding, or weigh less than 2.6 kg. RIVOXAMAC 15 TABLET is also not recommended in children with moderate to severe kidney disease. Consult your doctor before taking it.

Can I stop taking RIVOXAMAC 15 TABLET?

If you need to stop taking RIVOXAMAC 15 TABLET for any reason, ask your doctor to find out when you should stop taking it. Do not stop taking RIVOXAMAC 15 TABLET without consulting your doctor first.

REFERENCES

1. Barbara. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Venous Thromboembolism. Pharmacotherapy Handbook. Ninth edition. Page- 125, 126.

2 Rajshree Singh, Prabhu D. Emmady. Rivaroxaban. StatPearls [Internet]. StatPearls Publishing. May 2022. [Accessed on 1st June 2022] https://www.ncbi.nlm.nih.gov/books/NBK557502/#article-86483.s3

3. Bayer AG. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.3410.pdf

4. Bayer (Pty) Ltd. Rivaroxaban. [Revised in May 2022] [Accessed on 1st June 2022] https://www.bayer.com/sites/default/files/XARELTO_10_ENG_PIL.pdf

5. Janssen Pharmaceuticals, Inc. Rivaroxaban. [Revised in January 2022] [Accessed on 1st June 2022] https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/XARELTO-pi.pdf

USEFUL DIAGNOSTIC TESTS
D-dimer blood test
Duplex ultrasound
Venography
Magnetic resonance imaging (MRI) scan
PRODUCT DETAILS
Hsn Code
30049099
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RIVOXAMAC 15 Tablet 10's

US$18.00US$25.00 (-28%)

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