INTRODUCTION
REXIZOLE contains Clotrimazole which belongs to the group of medicines called Antifungals. It is used in the treatment of skin infections such as ringworm, athlete’s foot, fungal intertrigo and fungal infections of the outer and middle ear. Ringworm is a fungal infection affecting the skin and causing redness and itching.
An athlete’s foot is a fungal infection affecting the spaces between the toes. Fungal intertrigo is inflammation caused by skin-to-skin friction in warm, moist areas of the body (groin, between folds of skin on the abdomen, under the breasts, arms or between toes).Clotrimazole works by preventing fungal growth by blocking the production of enzymes responsible for the growth of the fungal cell.
REXIZOLE is not recommended for use in patients allergic to this medicine. REXIZOLE should be used with caution in pregnant and breastfeeding women. The common side effects of REXIZOLE are itching, rash, blisters, burning, discomfort, swelling, irritation, redness and peeling of the skin. Consult your doctor if symptoms get worse or persist.
USES OF REXIZOLE
Treats ringworm
Treats athlete’s foot
Treats fungal intertrigo
Treats fungal infections of the outer and middle ear
HOW REXIZOLE WORKS
REXIZOLE acts by specifically inhibiting the biosynthesis of ergosterol and other sterols (enzymes) required for cell membrane production, therefore inhibiting the division and growth of fungi eventually leading to cell death.
DIRECTIONS FOR USE
Always apply REXIZOLE as directed by your physician. It is for external use only. After washing and drying the infected area thoroughly apply a thin and even layer on it. In case of ear infection use 2-3 drops in the ears. Do not scratch the infected area even though it is itchy, keep the area clean and always wash your hands before and after the use of the medicine. Do not share towels, bathmats, etc. with other people, wash your socks, stockings and tights thoroughly in hot water to remove any shed skin or fungal spores. Change your footwear daily if possible. Your doctor will decide the right dose and duration for you depending on your age and disease condition.
SIDE EFFECTS OF REXIZOLE
COMMON
Itching, rash
Blisters, burning
Discomfort, swelling
Irritation
Redness, peeling of skin
RARE
Stop applying this medicine and contact your doctor immediately if you experience any of the following side effects:
Severe allergic reaction symptoms include skin rash, swelling of the lips, throat or tongue, face, weakness, nausea, feeling faint difficulty in swallowing or breathing
HOW TO MANAGE SIDE EFFECTS
Skin irritation:
Avoid sharing vessels, personal items, or cosmetics with others. Use disinfects on objects you use in public spaces, such as gym equipment. Drink plenty of water and eat a nutritious diet. Avoid using irritants or harsh chemicals. Use sunscreens to prevent sunburn and other sun damage. Wash hands regularly with soap and water. Consult your doctor if symptoms do not improve.
WARNING & PRECAUTIONS
PREGNANCY
REXIZOLE should be used with caution in pregnant women or women planning to have a baby only under the supervision of a midwife or doctor. Consult your doctor before applying it.
BREASTFEEDING
REXIZOLE should be used with caution in breastfeeding women only under the supervision of a doctor or midwife as it is not known if it is excreted in the breastmilk. If used topically on the nipple area, wash breasts before feeding the child. Consult your doctor before applying it.
DRIVING AND USING MACHINES
REXIZOLE has no or negligible influence on the ability to drive or use machines.
ALLERGY
Do not apply REXIZOLE if you are allergic to clotrimazole, other anti-fungal medicines or any other ingredients of this medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before applying REXIZOLE, inform your doctor if you are taking any of the following medicine:
Sofradex drops (contains dexamethasone, framycetin sulfate, and gramicidin) to treat infection/inflammation of the ear
Overdosage:
If you or anyone else accidentally swallow REXIZOLE, consult your doctor immediately or visit the nearby hospital. Symptoms include dizziness, nausea or vomiting.
SYNOPSIS
Drug : Clotrimazole
Pharmacological Category : Imidazoles
Therapeutic Indication : Fungal infections
Dosage Forms : Cream, ointment, solution, liquid, Vaginal tablet, cream,lotion, lozenges, soap, pessaries, spray, powder, paint,ointment, gel, ear drops
MORE INFORMATION
Keep REXIZOLE out of reach from children
Store at room temperature
FAQs ABOUT REXIZOLE
Q: What is REXIZOLE used for?
A: REXIZOLE contains Clotrimazole, which belongs to the group of medicines called antifungals. It is used in the treatment of skin infections such as ringworm, athlete’s foot, fungal intertrigo, and fungal infections of the outer and middle ear. Ringworm is a fungal infection affecting the skin that causes redness and itching. An athlete’s foot is a fungal infection affecting the spaces between the toes. Fungal intertrigo is inflammation caused by skin-to-skin friction in warm, moist areas of the body (groin, between folds of skin on the abdomen, under the breasts, arms, or between toes).
Q: How does REXIZOLE work?
A: REXIZOLE works by preventing fungal growth. Clotrimazole works by blocking the production of enzymes responsible for the growth of the fungal cell. This inhibition results in the breakage of cell membranes and fungal cell abnormalities, finally leading to alterations in the membrane-based activity of fungus. These lead to fungal cell death and the prevention of further fungal growth.
Q: How should I apply REXIZOLE?
A: Take REXIZOLE as advised by your physician. It is for external use. Do not swallow the medicine. Apply a thin, even layer to the infected area after thoroughly washing and drying it. Use 2-3 drops in the ears if you have an ear infection. Do not scratch the infected area, even though it is itchy; keep the area clean, and always wash your hands before and after the use of the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition. If you have any doubts regarding the doses, consult your doctor.
Q: What are the side effects of REXIZOLE?
A: The common side effects of REXIZOLE are itching, rash, blisters, burning, discomfort, swelling, irritation, redness, and peeling of the skin.
Q: Can REXIZOLE be used during pregnancy?
A: REXIZOLE should be used with caution and only under the supervision of a midwife or doctor in pregnant women or women planning to have a baby. Consult your doctor before applying it.
REFERENCES
1. KD Tripathi, Antimicrobial Drugs Essentials of pharmacology seventh edition 2013 page no- 792.
2. Dan Zhao Topical clotrimazole cream for the treatment of tinea cruris, A retrospective study November 2020 NCBI, PMC US National Library of Medicine, National Institute of Health. [Accessed on 12th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676513/
3. P R Sawyer, R N Brogden, R M Pinder, T M Speight, Avery. Clotrimazole: a review of its antifungal activity and therapeutic efficacy. [Accessed on 12th August 2022] https://pubmed.ncbi.nlm.nih.gov/1097234/
4. KVP Pharma + Veterinär Produkte GmbH. Electronic Medicines Compendium (EMC). Clotrimazole solution. [Revised on March 2018] [Accessed on 12th August 2022] https://www.medicines.org.uk/emc/product/2209/smpc
5. Palsons Derma. clotrimazole 2% topical gel. [Accessed on 12th August] https://www.palsonsderma.com/kansel-ds-gel-ds-lotion
6. Francoindian. Clotrimazole 1% solution. [Accessed on 12th August] http://www.francoindian.com/products/surfaz.htm
7. Parkerrobinson. Clotrimazole 1% lotion. [Accessed on 12th August] http://www.parkerrobinson.org/parkers-synthetic-products
Net Qty
1 N
Item Weight
40 g
Ingredient
CLOTRIMAZOLE
Hsn Code
30049029
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