MP 16mg Tablet 10’S

INTRODUCTION

MP 16MG TABLET contains Methylprednisolone which belongs to the group of medicines called Corticosteroids. It is used to treat problematic conditions of the adrenal glands (such as adrenal insufficiency, congenital adrenal hyperplasia and nonsuppurative thyroiditis).

It can also be used to treat various inflammatory auto-immune disease conditions affecting the bones and joints (Ex. rheumatoid arthritis, ankylosing spondylitis), skin and collagen (Ex. systemic lupus erythematosus, psoriasis), eyes (Ex. optic neuritis, uveitis or iritis), respiratory tract (Ex. asthma, tuberculosis), blood or blood vessels (Ex. leukaemia), bowel and gut (Ex. Crohn’s disease and ulcerative colitis) and brain (Ex. tuberculous meningitis).

It is also indicated in the treatment of drug induced hypersensitivity reactions and in other allergic reactions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis). It also helps in prevention of graft rejection following organ transplantation and increases urine output or reduces protein loss in urine among patients having kidney problems (such as nephrotic syndrome).

Take MP 16MG TABLET as advised by your physician. Do not stop taking MP 16MG TABLET or reduce the dose of methylprednisolone without consulting your doctor as it may lead to unpleasant withdrawal symptoms, especially if you are taking higher dose of methylprednisolone.

Before taking MP 16MG TABLET inform your doctor if you any viral infections, or any liver, kidney or heart problems. You must also inform your doctor if you have hypertension, diabetes, thyroid deficiency, glaucoma, skin problem, gut inflammation, muscle problems, osteoporosis, any types of tumors or cancer in the body, depression or any other forms of mental illness.

MP 16MG TABLET should be used in pregnant or breastfeeding women only if it is considered necessary by the physician. Avoid drinking grapefruit juice or eating grapefruit while taking MP 16MG TABLET as it may lead to unwanted side effects.

The most common side effects of taking MP 16MG TABLET are high blood pressure, swelling of body parts, muscle cramps or weakness, skin thinning, feeling sad or depressed and slowed growth in children. Consult your doctor if any of these side effect worsens.

You must also inform your doctor if you experience severe depression with suicidal thoughts or severe stomach pain with blood-stained stools or vomit.

USES OF MP 16MG TABLET

It is used to treat the following disease conditions:

Adrenal insufficiency and its associated conditions
Bone and joint problems (Ex. rheumatoid arthritis, ankylosing spondylitis)
Skin and collagen disorders (Ex. systemic lupus erythematosus, psoriasis)
Eye problems (Ex. optic neuritis, uveitis or iritis)
Respiratory tract diseases (Ex. asthma, tuberculosis)
Blood cancer (leukemia), lymph cancer (lymphoma)
Problems of bowel and gut (Ex. Crohn’s disease and ulcerative colitis)
Brain problems (Ex. tuberculous meningitis)
Drug induced hypersensitivity reactions
Allergic reactions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis)

It can also:

Prevent graft rejection following organ transplantation
Improve urine output or reduces protein loss in urine among patients having nephrotic syndrome
HOW MP 16MG TABLET WORKS

MP 16MG TABLET is a corticosteroid medicine with anti-inflammatory and immune suppressant properties. It boosts your body with sufficient corticosteroid levels (cortisol, aldosterone) during deficient conditions and helps your body to function properly.

It also reduces the release of certain chemicals (prostaglandins) in the body that causes inflammation. It prevents graft rejection by suppressing the immune functions and protects your kidney from damage in patients with kidney problems.

DIRECTIONS FOR USE

Take MP 16MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking MP 16MG TABLET without consulting your doctor.

SIDE EFFECTS OF MP 16MG TABLET
COMMON
High blood pressure (causing headache, or a general feeling of being unwell)
Swelling of body parts
Muscle cramps, weakness or wasting
Cataract, blurred vision
Slowed growth in children
Moon shaped face (Cushingoid facies)
Feeling sad, mood changes, mania, anxiety
Problems in sleeping
Difficulty in thinking, confusion, loss of memory, hallucinations
Fear or frightening thoughts
Acne, poor wound healing
Skin thinning
RARE

Contact your doctor immediately if you experience any of the following side effects while undergoing therapy with MP 16MG TABLET:

Signs of allergic reaction (such as skin rash, itching, blistering and peeling of the skin, swelling of the face, lips, mouth, throat which may lead to breathing difficulties)
Signs of bleeding in the gut (such as stomach pain which radiates until your back, bleeding from the anus, black or blood-stained stools, blood in vomit)
Increased infections causing fever or a general feeling of being unwell
Signs of flare up of a previous tuberculosis infection (such as coughing blood or pain in the chest)
Signs of pancreatitis (inflammation of pancreas causing severe stomach pain and vomiting)
Signs of blood clot in lungs (such as sharp chest pain, shortness of breath, coughing up blood)
Signs of increased pressure within the skull (such as severe headaches with vomiting, lack of energy and drowsiness) usually occurs once therapy is stopped
Thrombophlebitis (blood clots in vein supplying the legs causing leg pain, swelling, redness and tenderness)
Feeling depressed, suicidal thoughts
Blurred vision or other visual disturbances
HOW TO MANAGE SIDE EFFECTS

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

WARNING & PRECAUTIONS
PREGNANCY

MP 16MG TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before taking MP 16MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby.

BREASTFEEDING

MP 16MG TABLET should be used in breastfeeding women only if it is considered necessary by the physician. Therefore, inform your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you experience dizziness after taking MP 16MG TABLET.

ALCOHOL

Avoid consumption of alcohol while taking MP 16MG TABLET as it may make you feel drowsier.

KIDNEY

MP 16MG TABLET should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.

LIVER

MP 16MG TABLET should be used with caution in patients with liver diseases. Therefore, consult your doctor before taking it.

ALLERGY

Do not take MP 16MG TABLET if you are allergic to Methylprednisolone.

LUNGS

MP 16MG TABLET is not recommended for use in patients with fungal infection of the lungs. Therefore, consult your doctor before taking it.

HEART DISEASE

MP 16MG TABLET should be used with caution in patients with heart problems (such as recent heart attack or heart failure). Therefore, consult your doctor before taking it.

OTHERS

MP 16MG TABLET is not recommended for use if you:

Have serious untreated fungal infections (Ex. infection of lungs or esophagus)
Got vaccinated recently or scheduled for any upcoming vaccinations

Before taking MP 16MG TABLET, inform your doctor if you:

Have or had been in contact with someone who has chickenpox, measles or shingles
Have or ever had severe depression or bipolar disorder
Have a family history of mental illness
Have diabetes or a family history of diabetes
Have fits
Have or have a family history of glaucoma
Have viral or fungal infections of the eyes
Have hypertension (high blood pressure)
Have underactive thyroid gland (hypothyroidism)
Have inflammation of pancreas or gut lining (peritonium)
Have scleroderma (an autoimmune disorder causing skin tightness, cold extremities, joint pain and heart burn)
Have Kaposi’s sarcoma (a type of skin cancer)
Have any muscle problems (Ex. myasthenia gravis)
Have osteoporosis (brittle bones)
Have pheochromocytoma (a rare tumor of the adrenal glands)
Have skin abscess
Have stomach ulcer or other serious stomach or intestinal problems
Have thrombophlebitis (clots in veins)
Have or had tuberculosis
Have Cushing’s disease
Have brain injury due to trauma
Have any unusual stress
Are scheduled for any upcoming surgery (including dental surgery)

Use in pediatrics:

MP 16MG TABLET should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice before taking it.

Use in geriatrics:

MP 16MG TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking MP 16MG TABLET, inform your doctor if you are taking any of the following medicines such as:

Acetazolamide (a medicine used to treat glaucoma or edema)
Aminoglutethimide or cyclophosphamide (used for treating cancer)
Anticoagulants (used for blood thinning) such as acenocoumarol, phenindione and warfarin
Anti-cholinergic medicines used to treat myasthenia gravis (such as distigmine and neostigmine)
Medicines used to treat bacterial infections (Ex. isoniazid, erythromycin, clarithromycin and troleandomycin)
Medicines used to treat diabetes (Ex. metformin, glipizide)
Aprepitant or fosaprepitant (used to prevent nausea and vomiting)
Non-steroidal anti-inflammatory medicines (used for fever and pain relief) such as aspirin, ibuprofen
Medicines used to treat epilepsy (such as carbamazepine, phenytoin and primidone)
Carbenoxolone and cimetidine (used to treat stomach ulcer and acid reflux)
Ciclosporin, tacrolimus (medicines used to suppress immune function and to prevent graft rejection)
Medicines used to treat chest pain, hypertension or irregular heartbeat (such as digoxin, diltiazem or mibefradil)
Oral contraceptives (birth control pills) Ex. ethinylestridiol and norethisterone
Medicines used to treat HIV infection (such as ritonavir, indinavir, cobicistat)
Medicines used to treat fungal infection (such as ketoconazole, amphotericin B, itraconazole)
Muscle relaxants (Ex. pancuronium or vecuronium)
Diuretics (used to treat edema and hypertension) Ex. furosemide, chlorothiazide, hydrochlorothiazide
Medicines used to treat asthma (such as aminophylline, salmeterol, formoterol)
Rifampicin and rifabutin (used to treat tuberculosis)
Live vaccines

B. Drug-Food interaction:

Avoid drinking grapefruit juice or eating grapefruit while taking MP 16MG TABLET as it may lead to unwanted side effects.

Overdosage:

If you or anyone else accidentally took more MP 16MG TABLET, consult your doctor immediately or visit the nearby hospital straight away.

SYNOPSIS
Drug :  

Methylprednisolone

Pharmacological Category :  

Synthetic Glucocorticoids

Therapeutic Indication :  

Adrenal insufficiency, Auto Immune Disease, Allergic reactions, Prevent graft rejection, Proteinuria

Dosage Forms :  

Tablet, Injection, Cream

MORE INFORMATION
Keep MP 16MG TABLET out of reach of children
Store MP 16MG TABLET at room temperature
FAQs ABOUT MP 16MG TABLET

What is MP 16MG TABLET used for?

MP 16MG TABLET is a corticosteroid medicine used to treat adrenal insufficiency. It can also be used to treat drug induced hypersensitivity reactions, allergic reactions and various inflammatory auto-immune disease conditions affecting the skin, collagen, bones and joints, brain, gut, eyes etc. It also helps in prevention of graft rejection following organ transplantation and increases urine output among patients having kidney problems.

How to take MP 16MG TABLET?

Swallow MP 16MG TABLET with a glass of water. Do not crush or chew the medicine.

Is MP 16MG TABLET a steroid?

Yes. MP 16MG TABLET is synthetic corticosteroid used to treat problems of adrenal gland and various allergic, hypersensitivity and inflammatory autoimmune disease conditions.

What are the most common side effects of MP 16MG TABLET?

The most common side effects of taking MP 16MG TABLET are high blood pressure, swelling of body parts, muscle cramps or weakness, skin thinning, feeling sad or depressed and slowed growth in children. Consult your doctor if any of these side effect worsens.

Can MP 16MG TABLET make you feel high?

Yes. MP 16MG TABLET may make you feel high. Such symptoms may disappear once the therapy has been stopped. However, consult your doctor if it bothers you.

How does MP 16MG TABLET works?

MP 16MG TABLET boosts your body with sufficient corticosteroid levels and helps your body to function properly. It also reduces the release of certain chemicals in the body that causes inflammation. It also prevents graft rejection by suppressing the immune functions and protects your kidney from damage in patients with kidney problems.

How long will it take for MP 16MG TABLET to control my disease?

The time taken by MP 16MG TABLET to control the disease may vary from person-to-person depending upon the dose of methylprednisolone administered and disease severity.

Is MP 16MG TABLET safe to use in diabetic patients?

MP 16MG TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking MP 16MG TABLET as a precaution.

Who should not take MP 16MG TABLET?

MP 16MG TABLET is not recommended for use in patients with serious fungal infections. It is also not suitable for use in patients who got vaccinated recently.

Can I take a higher dose of MP 16MG TABLET?

No. It is not safe to take a higher dose of MP 16MG TABLET without consulting your doctor. If the prescribed dose is less effective for you, kindly consult your doctor for a suitable high dose or for an alternative therapy.

Can I take MP 16MG TABLET daily?

Your doctor will evaluate your health condition and suggests whether can you take MP 16MG TABLET every day or not.

Can I stop taking MP 16MG TABLET once by pain reduces?

Take MP 16MG TABLET for the stipulated duration recommended by your doctor to achieve maximum results. Do not stop taking MP 16MG TABLET or reduce the dose of methylprednisolone without consulting your doctor, as sudden cessation of the therapy may lead to unpleasant withdrawal symptoms such as skin itchiness, fever, headache, muscle pain, joint pain, runny nose, tiredness or weight loss, especially if you are taking higher dose of methylprednisolone.

Can MP 16MG TABLET be used in children?

MP 16MG TABLET should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice before taking it.

What to do if I forgot to take a dose of MP 16MG TABLET?

If you forgot to take a dose of MP 16MG TABLET, take it as soon as you remember. However, if it is time for the next dose of MP 16MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of MP 16MG TABLET to compensate the missed ones.

Will MP 16MG TABLET alter the effects of birth control pills?

MP 16MG TABLET may reduce the effects of birth control pills. Therefore, try to avoid taking birth control pills along with MP 16MG TABLET. Consult your doctor for advice.

Can MP 16MG TABLET be used in pregnant women?

MP 16MG TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before taking MP 16MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby.

REFERENCES

1. KD. Tripathi. Corticosteroids. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 313.

2. Antonio Ocejo, Ricardo Correa. Methylprednisolone. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. [Revised in December 2021]. [Accessed on 8th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK544340/

3. Jicheng Lv, MD, Hong Zhang, PhD, Muh Geot Wong, PhD. Effect of Oral Methylprednisolone on Clinical Outcomes in Patients with IgA Nephropathy: The TESTING Randomized Clinical Trial. JAMA Network. August 2017. [Accessed on 8th October 2022] https://jamanetwork.com/journals/jama/fullarticle/2646717

4. Pfizer Italia S.r.l. Electronic Medicines Compendium (EMC). [Revised in November 2018] [Accessed on 8th October 2022] https://www.medicines.org.uk/emc/files/pil.1085.pdf

5. Pfizer Italia S.r.l. Electronic Medicines Compendium (EMC). [Revised in November 2018] [Accessed on 8th October 2022] https://www.medicines.org.uk/emc/files/pil.1086.pdf

6. Methylprednisolone. Pfizer. [Revised in February 2019] [Accessed on 8th October 2022] https://labeling.pfizer.com/showlabeling.aspx?id=601

7. Central Drugs Standard Control Organization. Methylprednisolone Tablet 8mg. [Revised in September 2009]. [Accessed on 8th October 2022] https://cdscoonline.gov.in/CDSCO/Drugs

8. Predniwel 8. Leeford Healthcare Ltd. [Accessed on 8th October 2022] https://www.leeford.in/product/1072/predniwel-8

USEFUL DIAGNOSTIC TESTS
Absolute Eosinophil Count
Anti-Nuclear Antibody
Anti-ds-DNA Antibody
Anti-ds-DNA Antibody-IFA
Peripheral Smear Examination
Total IgE
Net Qty
1 N
Item Weight
17.5 g
Ingredient
METHYLPREDNISOLONE 16MG
Hsn Code
30043912
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