Laregab AT LS 100/10mg Tablet 10’S

INTRODUCTION

LAREGAB AT LS 100/10MG TABLET is a combination of Amitriptyline and Gabapentin which belongs to the group of medicines called Tricyclic Antidepressants and Antiepileptics. It is used in the treatment of neuropathic pain in adults. Neuropathic pain is a long-term weakness, numbness or pain caused by damage to the nerves in hands and legs characterized by a feeling of hot, burning, throbbing, shooting, sharp, tingling, numbness.

LAREGAB AT LS 100/10MG TABLET is not recommended for use in patients with severe liver disease and heart problems and it should be used with caution in patients having kidney problems or undergoing haemodialysis. Do not stop taking LAREGAB AT LS 100/10MG TABLET suddenly, as this may lead to increased risk of seizure.  

LAREGAB AT LS 100/10MG TABLET is not recommended for use in pregnant woman especially during the last few months of the pregnancy. Do not take LAREGAB AT LS 100/10MG TABLET if you are breast-feeding as it may pass through breast milk to the baby. Consult your doctor for advice before taking it.   

LAREGAB AT LS 100/10MG TABLET is not recommended for use in children and adolescents below 18 years of age and should be used with caution in elderly patients aged 65 years and above. Consult your doctor for advice before taking LAREGAB AT LS 100/10MG TABLET.

The most common side effects of taking LAREGAB AT LS 100/10MG TABLET are dizziness, drowsiness, muscle pain, nausea, vomiting and stomach pain. Consult your doctor if any of these side effect worsens.

USES OF LAREGAB AT LS 100/10MG TABLET
Treats neuropathic pain (long term pain caused by damage to the nerves) in adults
HOW LAREGAB AT LS 100/10MG TABLET WORKS

LAREGAB AT LS 100/10MG TABLET works effectively in reducing the neuropathic pain where Amitriptyline effects are related to its mood-altering activities which acts by increasing the concentration of the neurotransmitters called serotonin and norepinephrine as these substances are found to be low in the anxiety patients and Gabapentin acts by blocking the pain signals travelling through the damaged nerves and the brain and hence prevents nerve pain.

DIRECTIONS FOR USE

Take LAREGAB AT LS 100/10MG TABLET as advised by your physician. Swallow LAREGAB AT LS 100/10MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking LAREGAB AT LS 100/10MG TABLET without consulting your doctor.

SIDE EFFECTS OF LAREGAB AT LS 100/10MG TABLET
COMMON
Sleepiness/drowsiness, dizziness, lack of coordination, tiredness
Dizziness while standing up (orthostatic hypotension)
Irregular or fast heartbeat, heart block
Eating disorder characterized by low body weight, increased appetite
Anger, nervousness, difficulty with thinking, confusion, mood changes, depression, anxiety
Jerky movements, loss of memory, tremor, headache, sensitive skin, decreased sensation (numbness), unusual eye movement, increased, decreased or absent reflexes, difficulty with speaking and coordination, difficulty sleeping
Blurred vision, double vision
Feeling of spinning (vertigo)
High blood pressure
Difficulty in breathing, sore throat, cough, dry and congested nose
Vomiting, nausea
Problems with teeth, inflamed gums
Stomach pain, diarrhea, indigestion, constipation, flatulence, dry mouth or throat
Facial swelling, bruises, rash, itching, acne
Muscles and joint pain, back pain, muscle twitching
Difficulties with erection (impotence) in male
Swelling in the legs and arms, weakness, pain, feeling unwell, difficulty with walking
Increase in weight
Rhythmic shaking movements of body parts
Excessive sweating (anxiety)
Slurred or slow speech
Agitation (anxiety)
Sexual disturbances
Disturbance in attention
Altered taste sensation
Dilated pupils
UNCOMMON
Allergic reaction such as hives
Decreased movements
Difficulty in swallowing
Swelling of the face, limbs and trunk
Excitement, nightmares
Fits, ringing in ears
Nettle rash (urticaria)
Difficulties passing urine
Increased breast milk production or its outflow without breast feeding
Increased pressure in the eyeball
RARE
Loss of consciousness
Decreased appetite
Delirium (especially in elderly patients), hallucinations
Swelling of the salivary glands
Hair loss
Increased sensitivity to sunlight
Breast enlargement in men
Weight loss

Stop taking LAREGAB AT LS 100/10MG TABLET and contact your doctor immediately if you experience any of the following side effects:

Swelling of the skin, lips and face
Rash and redness and/or hair loss
Signs of acute pancreatitis such as nausea and vomiting, persistent stomach pain
Breathing problems, swollen glands 
Severe weakness, unusual bruising or bleeding
Frequent infections, muscle pain
Hives (nettle rash), facial swelling due to allergies (Quincke’s oedema or angioedema), difficulty in breathing, severe dizziness with very fast heartbeat and sweating
Blistering of the skin and rapid deterioration of general condition, peeling of skin (including slight bleeding) of eyes, nose, mouth/ lips or genitals (Stevens Johnson-Syndrome, Lyell-Syndrome, Erythema multiforme) and sensitivity to light
Eye pain, intermittent blurred vision, rainbow vision
Jaundice (yellowing of the skin or white of the eyes)
Persistent sore throat and fever
Suicidal thoughts
HOW TO MANAGE SIDE EFFECTS

Nausea or Vomiting:

Take LAREGAB AT LS 100/10MG TABLET with or just after meals. Stick to simple meals. Try to avoid oil rich or spicy foods, sugary snacks and drinks. Try to drink liquid slowly along with your meals or in between meals. Consult your doctor if the symptom worsens.

Dizziness:

Lie or sit down immediately when you feel dizzy. If you’re feeling severe episode of spinning (vertigo), lie in a dark and quite place with eyes closed. Try to avoid vehicle driving. Discuss with your doctor if the symptom worsens.

Headache:

Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage on scalp or head with mild pressure. Consult your doctor if the symptom worsens.     

Dry mouth:

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if the symptom worsens.     

Stomach pain:

Try to rest and relax. Try to have smaller and frequent meals. Keep a heat pad on your stomach. Talk to your if the symptoms does not improve.

WARNING & PRECAUTIONS
PREGNANCY

LAREGAB AT LS 100/10MG TABLET is not recommended for use in pregnant woman unless considered clearly necessary, especially during the last few months of pregnancy as the new-born may have withdrawal symptoms such as tremors (shaking movements), irregular breathing, irritability, increased muscle tension, poor drinking, crying loudly, urinary retention and constipation. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

BREASTFEEDING

Do not take LAREGAB AT LS 100/10MG TABLET if you are breast-feeding as it may pass through breast milk to the baby. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

DRIVING AND USING MACHINES

Do not drive or operate any machines because LAREGAB AT LS 100/10MG TABLET may cause dizziness, drowsiness and tiredness.

ALCOHOL

Avoid consumption of alcohol while taking LAREGAB AT LS 100/10MG TABLET as it may cause sleepiness or dizziness.

KIDNEY

LAREGAB AT LS 100/10MG TABLET should be used with caution in patients with kidney problems or those who are undergoing haemodialysis. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

LIVER

LAREGAB AT LS 100/10MG TABLET is not recommended for use in patients having severe liver disease. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

ALLERGY

Do not take LAREGAB AT LS 100/10MG TABLET if you are allergic to Amitriptyline or Gabapentin.

LUNGS

LAREGAB AT LS 100/10MG TABLET should be used with caution in patients with respiratory disorders. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

HEART DISEASE

LAREGAB AT LS 100/10MG TABLET is not recommended for use in patients who had heart attack (myocardial infarction), disturbances in heart rhythm, heart block or coronary artery disease. It should be used with caution in patients with pre-existing heart disease. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

OTHERS

Before taking LAREGAB AT LS 100/10MG TABLET, inform your doctor if you:

Have acute pancreatitis with signs of persistent stomach pain, nausea and vomiting
Have nervous system disorders
Have a problem resulting in low levels of potassium or magnesium or high levels of potassium in the blood
Have a planned surgery
Have an overactive thyroid gland

Use in pediatrics:

LAREGAB AT LS 100/10MG TABLET is not recommended for use in children and adolescents below 18 years of age. Consult your child’s doctor for advice before administration of LAREGAB AT LS 100/10MG TABLET.

Use in geriatrics:

LAREGAB AT LS 100/10MG TABLET should be taken with caution in elderly patients (aged 65 years or above) especially in patients with impaired kidney function. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

INTERACTIONS

A. Drug – Drug interactions:

Before taking LAREGAB AT LS 100/10MG TABLET, inform your doctor, if you are taking any of the following medicines:

Antacids such as aluminum hydroxide and magnesium hydroxide (medicines used to reduce heart burn, indigestion)
Fluoxetine, paroxetine, fluvoxamine, duloxetine, bupropion and monoamine oxidase inhibitors like phenelzine, iproniazid, isocarboxazid, nialamide or tranylcypromine (medicines used to treat depression)
Terbinafine, itraconazole, fluconazole, ketoconazole, (used to treat fungal infections)
Erlotinib (medicine used for certain types of cancer)
Warfarin and phenprocoumon (medicines used as a blood thinning agent)
Rifampicin (medicine used to treat tuberculosis)
St john’s wort (hypericum perforatum) (used to treat mild depression)
Glyceryl trinitrate, adrenaline, ephedrine, isoprenaline, noradrenaline, atenolol, propranolol (medicines used to treat heart disease)
Phenylephrine and phenylpropanolamine (medicines used to treat cough and cold)
Medicines to treat high blood pressure (Ex. diltiazem and verapamil, betanidine, reserpine, methyldopa, guanethidine and clonidine)
Medicines to treat parkinson’s disease and gastrointestinal disorders (Ex. atropine, hyoscyamine)
Thioridazine (medicine used to treat schizophrenia)
Nefopam, tramadol, morphine, buprenorphine (used to treat pain)
Barbiturates like phenobarbital, pentobarbital (medicines used to treat insomnia) or other sleeping medicines like triazolam, zolpidem
Cimetidine (used to treat stomach ulcers)
Methylphenidate (used to treat ADHD-attention-deficit/hyperactivity disorder)
Ritonavir (medicine used to treat HIV)
Oral contraceptives
Valproic acid, phenytoin and carbamazepine (medicines used to treat epilepsy)
Thyroxine (used to treat underactive thyroid)
Baclofen (medicine used as muscle relaxant)

Overdosage:

If you or anyone else accidentally takes too much of LAREGAB AT LS 100/10MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of LAREGAB AT LS 100/10MG TABLET includes loss of consciousness, dizziness, double vision, slurred speech, drowsiness, diarrhoea, dilated pupils, fast or irregular heartbeats, difficulties passing water, dry mouth and tongue, intestinal blockage, low blood pressure, weak pulse, pallor (pale skin), difficulty in breathing, blue discolouration of the skin, decreased heart rate, drowsiness, loss of consciousness, coma, fits, fever, agitation, confusion, hallucinations, uncontrolled movements, various cardiac symptoms such as heart block, heart failure, cardiogenic shock, metabolic acidosis, low levels of blood potassium (hypokalaemia).   

SYNOPSIS
Drug :   Amitriptyline, Gabapentin
Pharmacological Category :   Tricyclic Antidepressants, Antiepileptics
Therapeutic Indication :   Neuropathic pain
Dosage Forms :   Tablet 
MORE INFORMATION
Keep LAREGAB AT LS 100/10MG TABLET out of reach of children
Store LAREGAB AT LS 100/10MG TABLET at room temperature  
FAQs ABOUT LAREGAB AT LS 100/10MG TABLET

What is LAREGAB AT LS 100/10MG TABLET and why is it given?

LAREGAB AT LS 100/10MG TABLET contains Amitriptyline and Gabapentin which is used in the treatment of neuropathic pain which is a long-term weakness, numbness or pain caused by damage to the nerves in hands and legs characterized by a feeling of hot, burning, throbbing, shooting, sharp, tingling, numbness.

How LAREGAB AT LS 100/10MG TABLET works?

LAREGAB AT LS 100/10MG TABLET works effectively in reducing the neuropathic pain where Amitriptyline effects are related to its mood-altering activities which acts by increasing the concentration of the neurotransmitters called serotonin and norepinephrine as these substances are found to be low in the anxiety patients and Gabapentin acts by blocking the pain signals travelling through the damaged nerves and the brain and hence prevents nerve pain.

Is LAREGAB AT LS 100/10MG TABLET safe to use in pregnant women?

LAREGAB AT LS 100/10MG TABLET is not intended for use in pregnant and breast-feeding woman especially during the last few months of pregnancy as the new-born may have withdrawal symptoms such as irritability, irregular breathing pattern, increased muscle tension, tremor (shaking movements), poor drinking, crying loudly, urinary retention, and constipation. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

LAREGAB AT LS 100/10MG TABLET can be used in patients with heart problems?

LAREGAB AT LS 100/10MG TABLET is not recommended for use in patients who had heart attack (myocardial infarction), disturbances in heart rhythm, heart block or coronary artery disease. It should be used with caution in patients with pre-existing heart disease. Consult your doctor before taking LAREGAB AT LS 100/10MG TABLET.

Does LAREGAB AT LS 100/10MG TABLET cause dizziness?

Yes, LAREGAB AT LS 100/10MG TABLET may cause dizziness in some individuals. Lie or sit down immediately when you feel dizzy. If you’re feeling a severe episode of vertigo, lie in a dark and quite place with eyes closed. Talk to your doctor if the symptom does not improve.

REFERENCES

1. KD. Tripathi. Antidepressants and Anti-Anxiety Drugs and Antiepileptics. Essentials of medical pharmacology. Eighth edition. 2019. Page – 485-486, 439-442.

2. Mariangela Panebianco, Sarah Al-Bachari, Jennifer Weston, Jane L Hutton, Anthony G Marson. Gabapentin add-on treatment for drug-resistant focal epilepsy. National Library of Medicine, National center for biotechnology information. PubMed Central. October 2018. [Accessed on 8th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517293/ 

3. Kim Lawson, Shaker A. Mousa. Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. National Library of Medicine, National center for biotechnology information. PubMed Central. June 2017. [Accessed on 8th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489810/

4. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021]. [Accessed on 8th July 2022] https://www.medicines.org.uk/emc/files/pil.9543.pdf

5. Accord, Barnstaple, EX32 8NS, UK. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 8th July 2022] https://www.medicines.org.uk/emc/files/pil.5698.pdf

USEFUL DIAGNOSTIC TESTS
Electroencephalogram
Net Qty
1 N
Item Weight
17.5 g
Ingredient
amitriptyline+gabapentin
Hsn Code
30049099
Show more