INTRODUCTION
EBAZIDE M is a combination of Ebastine and Montelukast which belongs to the group of medicines called H1 receptor blockers and Leukotriene receptor antagonists respectively. It is used to treat seasonal allergic rhinitis.
Allergic rhinitis (also known as hay fever) is an allergic condition caused due to allergens such as pollens, dusts, molds, or flakes of skin from certain animals. It can occur seasonally or year-round and often characterized by inflammation of the inner lining of the nose accompanied by nasal decongestion, repeated sneezing, or a red, watery, and itchy eyes.
Ebastine is a selective H1 receptor blocker and montelukast is a leukotriene receptor antagonist. They both act together and prevent the release of certain chemicals (histamines and leukotriene) in the body that causes inflammation, swelling and narrowing of the nasal tract.
Take EBAZIDE M for the stipulated duration instructed by your doctor. Do not stop taking EBAZIDE M once your symptoms subside during the mid-way of the therapy as it may make your symptoms to reappear. EBAZIDE M is suitable for use in both adults and in adolescents aged above 15 years.
Before taking EBAZIDE M inform your doctor if you have asthma or any other breathing problems. You must also inform your doctor if you have any liver or kidney problems before taking EBAZIDE M as a precaution. Consult your doctor before taking EBAZIDE M if you are pregnant or breast-feeding.
EBAZIDE M may cause drowsiness or sleepiness. Therefore, avoid driving or operating any heavy tools or performing activities that requires complete concentration.
Other most common side effects of taking EBAZIDE M are headache, dry mouth, stomach pain, upper respiratory infection, and vomiting. Consult your doctor if any of these side effect worsens. Also, talk to your doctor if you or your child experience any behavioral or mood changes after taking EBAZIDE M.
USES OF EBAZIDE M
Treats seasonal allergic rhinitis
HOW EBAZIDE M WORKS
EBAZIDE M effectively controls and prevents the symptoms of allergic rhinitis. It contains two medicines namely, ebastine and montelukast. Ebastine reduces nasal congestion, repeated sneezing, nasal itching, and watery eyes by blocking the release of certain chemicals (histamines) in the nasal tract that triggers the allergic reactions. Montelukast reduces inflammation and swelling of the airways by blocking the release of certain chemicals (leukotriene) in the airways that causes inflammation. Together, they reduce the unpleasant symptoms of allergic rhinitis.
DIRECTIONS FOR USE
Take EBAZIDE M as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking EBAZIDE M without consulting your doctor even if your symptom subsides.
SIDE EFFECTS OF EBAZIDE M
COMMON
Headache
Stomach pain
Upper respiratory infection
Diarrhea
Nausea, vomiting
Skin rash
Fever
UNCOMMON
Difficulty in sleeping, nightmares, walking in the sleep
Feeling irritated, anxious, or restless
Dizziness or drowsiness
Sensation of tingling or numbness
Nosebleeds
Dry mouth, indigestion
Bruising, itching
Joint pain, muscle pain or cramps
Bedwetting in children
Feeling tired or weak
Swelling of body parts
RARE
Disturbance in attention, memory impairment
Uncontrolled muscle movements
Stop taking EBAZIDE M and contact your doctor immediately if you experience any of the following side effects:
Allergic reactions symptoms (such as swelling of the face, lips, throat or tongue, which may cause difficulty in breathing or swallowing)
Behavior and mood changes such as agitation, aggressive behavior or hostility, depression
Fits (seizures)
Increased bleeding tendency
Tremor
Palpitations (fast or pounding heartbeat)
HOW TO MANAGE SIDE EFFECTS
Nausea and Vomiting:
Take EBAZIDE M with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Diarrhea:
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
EBAZIDE M should be used in pregnant women only if considered necessary by the physician. Your doctor will access your condition and prescribes it to you only if the potential benefits overweigh the risk to the growing fetus. Therefore, inform your doctor before taking EBAZIDE M if you are pregnant or think you may be pregnant.
BREASTFEEDING
It is not known whether EBAZIDE M can pass through breast milk or not. Therefore, it should be used in breast-feeding women only if considered necessary by the physician.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience dizziness and drowsiness after taking EBAZIDE M.
ALCOHOL
Avoid consumption of alcohol while taking EBAZIDE M as it could make you feel dizzy or drowsy.
KIDNEY
EBAZIDE M should be used with caution in patients with kidney problems (such as renal insufficiency). Therefore, consult your doctor before taking it.
LIVER
EBAZIDE M should be used with caution in patients with severe liver problems (such as hepatic impairment or hepatic insufficiency). Therefore, consult your doctor before taking it.
ALLERGY
Do not take EBAZIDE M if you are allergic to Ebastine or Montelukast.
LUNGS
EBAZIDE M should be used with caution in patients with asthma or breathing difficulties. Therefore, consult your doctor before taking it.
OTHERS
EBAZIDE M is not recommended for use if you have:
Phenylketonuria due to the presence of aspartame
Before taking EBAZIDE M, inform your doctor if you have:
Any behavior or mood related changes
Use in pediatrics:
EBAZIDE M should be used in children and in adolescents (aged 15 years or older) only if prescribed by the physician. It is generally not recommended for use in children aged below 15 years. However, consult your doctor before taking it.
Use in geriatrics:
EBAZIDE M should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interaction:
Before taking EBAZIDE M, inform your doctor if you are taking any of the following:
Medicines used to treat fungal infections (Ex. ketoconazole and itraconazole)
Medicines used to treat bacterial infections (ex. clarithromycin, josamycin, erythromycin and rifampicin)
Non-steroidal anti-inflammatory drugs (used for pain relief) Ex. aspirin
Medicines used to treat epilepsy (Ex. phenytoin, phenobarbital)
Gemfibrozil (a medicine used to treat high blood cholesterol levels)
Overdosage:
If you or anyone else accidentally took more EBAZIDE M, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include abdominal pain, sleepiness, thirst, headache, vomiting, and hyperactivity.
SYNOPSIS
Drug :
Ebastine, Montelukast
Pharmacological Category :
H1 receptor blockers, Leukotriene receptor antagonists
Therapeutic Indication : Seasonal allergic rhinitis
Dosage Forms :
Tablet
MORE INFORMATION
Keep EBAZIDE M out of reach of children
Store EBAZIDE M at room temperature
FAQs ABOUT EBAZIDE M
How long should I take EBAZIDE M?
Take EBAZIDE M as long as your doctor prescribes it to you. It is typically given for a period of 14 days (2 weeks). However, this period may vary from person-to-person depending upon the severity of the allergic condition. Allergic rhinitis is a heterogenous disorder that may occur year-round or seasonally. You may have to take medicines whenever you experience an allergic symptom. Therefore, consult your doctor regarding the duration of therapy with EBAZIDE M.
Can I take EBAZIDE M for asthma?
Studies have shown that EBAZIDE M can prevent the symptoms of asthma. However, consult your doctor before taking EBAZIDE M if you wish to treat asthma.
How long will it take for EBAZIDE M to show the results?
It may take around 3-5 hours for EBAZIDE M to show its effects. However, it may take around 2-4 weeks to achieve complete results. For more information regarding the onset of action consult your doctor.
Can EBAZIDE M be used in children?
EBAZIDE M should be used in children and in adolescents (aged 15 years or older) only if prescribed by the physician. It is generally not recommended for use in children aged below 15 years. However, consult your doctor before taking it.
Can EBAZIDE M be used during pregnancy?
EBAZIDE M should be used in pregnant women only if considered necessary by the physician. Your doctor will access your condition and prescribes it to you only if the potential benefits overweigh the risk to the growing fetus. Therefore, inform your doctor before taking EBAZIDE M if you are pregnant or think you may be pregnant.
Can I stop taking EBAZIDE M once my symptoms subside?
No. Do not stop taking EBAZIDE M without consulting your doctor as it may cause the allergic symptoms to reappear. Make sure to take EBAZIDE M for the stipulated duration recommended by your doctor to achieve maximum results.
What should I do if I forgot to take a dose of EBAZIDE M?
If you forgot a dose of EBAZIDE M, take it as soon as you remember. However, if it is time for the next dose, skip the missed one and take the next one at regular times. Do not take a double dose of EBAZIDE M to compensate the missed ones.
What are the side effects of EBAZIDE M?
The most common side effects of taking EBAZIDE M are dizziness, drowsiness, headache, dry mouth, stomach pain, upper respiratory infection, and vomiting. Consult your doctor if any of these side effect worsens. Also, talk to your doctor if you or your child experience any behavioral or mood changes after taking EBAZIDE M.
What are the uses of EBAZIDE M?
EBAZIDE M is used to treat seasonal allergic rhinitis in both adults and in adolescents aged above 15 years.
Will taking a higher dose of EBAZIDE M be more effective?
Do not consume a higher dose of EBAZIDE M than the one prescribed by your doctor, as it may lead to unwanted side effects. Your doctor will decide the correct dose for you, depending on your age and disease condition. If the prescribed dose, does not help you, contact your doctor.
Can EBAZIDE M cause dryness of mouth?
Yes. EBAZIDE M may cause dryness of mouth. If you experience mouth dryness, drink plenty of water or fluids at regular intervals. Frequent small sips of water may be beneficial. However, if it bothers you or if your condition worsens contact your doctor.
Will EBAZIDE M make me feel more sleepy?
Yes. EBAZIDE M may cause drowsiness or sleepiness. Therefore, avoid driving or operating any heavy tools or performing activities that requires complete concentration. Try to rest and relax. Get enough sleep. Do not consume excessive alcohol. Consult your doctor if your condition worsens.
REFERENCES
1. KD. Tripathi. Histamine and Antihistaminics & Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 167 & 228.
2. Rajashekar Y R1, Shobha S N. Randomized prospective double-blind comparative clinical study of ebastine and its combined preparation of montelukast in persistent allergic rhinitis. National Journal of Physiology, Pharmacy and Pharmacology. September 2017. [Accessed on 8th July 2022] https://www.ejmanager.com/mnstemps/28/28-1505330264.pdf?t=1657300928
3. Getz Pharma Pvt. Ltd. [Accessed on 8th July 2022] https://getzpharma.com/wp-content/uploads/2020/01/Ebaget-D-leaflet.pdf
4. Accord Healthcare Ltd. Electronic Medicines Compendium (EMC) [Revised on September 2020] [Accessed on 8th July 2022] https://www.medicines.org.uk/emc/files/pil.1243.pdf
PRODUCT DETAILS
Country Of Origin
India
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