INTRODUCTION
DEPNOC 25MG contains Dosulepin which belongs to the group of medicines called Antidepressants. It is used in the treatment of depression (mood disorder causing persistent feeling of sadness and loss of interest) and also helps to reduce the feelings of anxiety (intense, excessive, persistent worry and fear about everyday situations), this medicine is used only when other medicines are not suitable.
DEPNOC 25MG is not recommended for use in patients with liver problems, irregular heartbeat or any other heart problems, mania (feeling over excited with unusual behaviour), glaucoma (increased pressure in eye), prostate problems and fits.
Before taking DEPNOC 25MG inform your doctor if you have any planned surgeries (such as dental or general surgery), intolerance to certain sugars and thyroid problems. Avoid consumption of alcohol during treatment with DEPNOC 25MG as it can make the drowsiness worse.
DEPNOC 25MG should be used in pregnant and breast-feeding women only if clearly advised by the doctor. It is not recommended for use in children and adolescents (below the age of 18 years) and it should be used with caution in elderly patients due to increased risk of certain side effects.
The most common side effects of taking DEPNOC 25MG are dry mouth, blurred vision, dizziness, constipation, sedation and difficulty in passing urine. Consult with your doctor if any of the side effect worsens.
USES OF DEPNOC 25MG
Treats depression
Reduce the feelings of anxiety
HOW DEPNOC 25MG WORKS
DEPNOC 25MG acts on central nervous system (CNS) which works by enhancing the activity of certain neurotransmitters (such as serotonin and noradrenaline) in the brain. It also works by stopping the reabsorption of neurotransmitters into the nerve cells in the brain. Thus, results in prolonging their effects and helps to relieve depression and lighten the mood.
DIRECTIONS FOR USE
Take DEPNOC 25MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF DEPNOC 25MG
COMMON
Dry mouth
Blurred vision
Heartbeat changes
Dizziness
Constipation
Sedation
Difficulty in passing urine
UNCOMMON
Severe allergic reaction (skin rash, itching, swollen face or tongue, collapse, shortness of breath, collapse)
Severe low blood pressure
Increased sweating
Tiredness or sleepiness
Confusion and hallucination (strange vision or sounds)
Tremors
Changes in libido (sex drive)
RARE
Severe mood changes such as extreme excitability
Stop taking DEPNOC 25MG and inform your doctor immediately if you experience any of the following side effects:
Skin rash or difficulty in breathing
Thoughts of harming or killing yourself
Bone marrow depression or reduction in some blood cells (signs include unusual bruising, abnormal bleeding, mouth ulcers, sore throat and fever)
Liver problems associated with yellowing of the skin and eyes (jaundice)
Convulsions (fits)
Irregular heartbeat (more common with high dosage)
HOW TO MANAGE SIDE EFFECTS
Constipation:
Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatment for constipation.
Dry mouth:
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Dizziness:
Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. Consult your doctor if the symptom gets worse.
Tiredness:
Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
DEPNOC 25MG should be used in pregnant women only if clearly advised by your doctor. Consult your doctor before taking it.
BREASTFEEDING
DEPNOC 25MG should be used in breastfeeding women only if clearly advised by your doctor. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or use machines if you feel drowsy after taking DEPNOC 25MG. Consult your doctor for advice.
ALCOHOL
Avoid consumption of alcohol during treatment with DEPNOC 25MG as it can make the feeling of drowsiness worse.
LIVER
DEPNOC 25MG is not recommended for use in patients with liver problems. Consult your doctor before taking DEPNOC 25MG.
ALLERGY
Do not take DEPNOC 25MG if you are allergic to Dosulepin or any other ingredients of this medicine.
HEART DISEASE
DEPNOC 25MG is not recommended for use in patients with irregular heartbeat or any other heart problems. Consult your doctor before taking DEPNOC 25MG.
OTHERS
DEPNOC 25MG is not recommended for use if you:
Have mania (feeling over excited with unusual behaviour)
Have glaucoma (increased pressure in eye)
Have fits (epilepsy)
Have prostate problems (difficulty in passing urine)
Before taking DEPNOC 25MG inform your doctor if you:
Have any planned surgeries (general or dental surgery)
Have thyroid problems
Are intolerant to certain sugars
Use in paediatrics:
DEPNOC 25MG is not recommended for use in children and adolescents (under 18 years of age). Consult child’s doctor for advice.
Use in geriatrics:
DEPNOC 25MG should be used with caution in elderly patients due to increased risk of side effects such as agitation, confusion and light headedness. Consult your doctor before taking DEPNOC 25MG.
INTERACTIONS
A. Drug–Drug Interactions:
Before taking DEPNOC 25MG inform your doctor if you are taking any of the following medicines:
Medicines used to treat depression such as selective serotonin reuptake inhibitor (SSRIs) (Ex. citalopram, fluoxetine) and mono-amine oxidase inhibitor (MAOI) (Ex. isocarboxazid, phenelzine)
Medicines used to treat underactive thyroid (Ex. Levothyroxine)
Medicines used to treat epilepsy (Ex. phenobarbitone), insomnia (Ex. amylobarbitone) and behavioural problems (Ex. methylphenidate)
Medicine containing an opioid (Ex. codeine, morphine, dihydrocodeine, co-proxamol and co-dydramol) (used to treat pain)
Medicines used to treat heart problems and asthma (also as cough and cold remedies), sympathomimetic agents (Ex. ephedrine, pseudoephedrine, adrenaline and noradrenaline)
Medicines used to treat high blood pressure (Ex. guanethidine) and regulate heartbeat (Ex. sotalol)
Terfenadine, astemizole (used to treat hay fever or allergy)
Halofantrine (used to treat malaria)
Overdosage:
If you or anyone else accidentally take too much of DEPNOC 25MG, consult your doctor immediately or visit the nearby hospital as it may seriously harm you and cause life-threatening problems.
SYNOPSIS
Drug :
Dosulepin
Pharmacological Category :
Tricyclic Antidepressants
Therapeutic Indication : Depression, Anxiety
Dosage Forms :
Tablet
MORE INFORMATION
Keep DEPNOC 25MG out of reach of children
Store at room temperature
FAQs ABOUT DEPNOC 25MG
What is DEPNOC 25MG and why is it given?
DEPNOC 25MG contains Dosulepin which belongs to the group of medicines called Antidepressants. It is used in the treatment of depression and also helps to reduce the feelings of anxiety, this medicine is used only when other medicines are not suitable.
Can I stop taking DEPNOC 25MG on my own?
You should not stop taking DEPNOC 25MG suddenly on your own without the advice of your doctor. Your doctor may gradually withdraw the dose in case of stopping the medicine. If you stop taking DEPNOC 25MG suddenly you may experience some withdrawal symptoms like irritability, insomnia and excessive perspiration (sweating).
Is DEPNOC 25MG safe to use in pregnant and breast-feeding women?
DEPNOC 25MG should be used in pregnant and breast-feeding women only if clearly advised by the doctor. Consult your doctor before taking DEPNOC 25MG if you are pregnant or planning to get pregnant or breast-feeding your child.
Can I drive or operate heavy machines after taking DEPNOC 25MG?
DEPNOC 25MG can cause drowsiness. Therefore, it is not advisable to drive or use machineries and tools until you feel normal again. Consult your doctor for advice before taking DEPNOC 25MG.
Can DEPNOC 25MG be used in elderly patients?
DEPNOC 25MG should be used with caution in elderly patients due to increased risk of side effects such as agitation, confusion and light headedness. Consult your doctor before taking it.
REFERENCES
1. KD. Tripathi. Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 459.
2. T Nakagawa, K Ukai, S Kubo. Antidepressive effects of the stereoisomer cis-dosulepin hydrochloride. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 1993 [Accessed on 14th June 2022] https://pubmed.ncbi.nlm.nih.gov/8447840/
3. P Zusky, T C Manschreck, C Blanchard, J Rosenbaum, C Elliot, P Lou. Dothiepin hydrochloride: treatment efficacy and safety. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 1986. [Accessed on 14th June 2022] https://pubmed.ncbi.nlm.nih.gov/3531188/
4. Dosulepin. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Revised in September 2022] [Accessed on 14th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Dosulepin#section=Mechanism-of-Action
5. Teva Pharmaceuticals Works Pvt Ltd. Dosulepin. [Revised in March 2021]. [Accessed on 14th June 2022] https://products.tevauk.com/mediafile/id/50662.pdf
6. Teofarma S.r.l. Health Products Regulatory Authority (HPRA). [Revised in July 2020] [Accessed on 14th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/0cc11c1c-a57e-470f-a788-57d351b29341.pdf
PRODUCT DETAILS
Net Qty
1 N
Item Weight
17.5 g
Ingredient
DOSULEPIN(DOTHIEPIN) 25 mg
Hsn Code
30049099
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