INTRODUCTION
ASTANOL TABLET contains Allylestrenol which belongs to group of medicines called Progestogens. It is used to treat intrauterine growth retardation (growth of the foetus is lesser than its normal growth rate), threatened abortion (vaginal bleeding at less than 20 weeks of gestation), and threatened premature delivery (onset of labor between 24 and 37 weeks of pregnancy) in affected women.
ASTANOL TABLET is also used to treat habitual abortion. Habitual abortion is a condition that occurs due to sequential loss of three or more pre-viable pregnancies in affected women which is generally characterized by symptoms such as crampy pelvic pain, and bleeding.
ASTANOL TABLET is not recommended for use in patients with thrombophlebitis (blood clot in vein), undiagnosed vaginal bleeding, incomplete abortion, stroke, and/or severe hepatic impairment.
Before taking ASTANOL TABLET, inform your doctor if you have lung, kidney, or heart disease, epilepsy, seizures, or migraine.
ASTANOL TABLET can be taken during pregnancy. Consult with your doctor before taking. ASTANOL TABLET should be used with caution in breastfeeding women. This medicine is not recommended for use in children and adolescents (below 16 years of age). Consult your doctor before taking the medicine.
The most common side effects of taking ASTANOL TABLET are nausea, vomiting or stomach discomfort. Consult your doctor if any of these symptoms worsens.
USES OF ASTANOL TABLET
Treats,
Intrauterine growth retardation
Threatened abortion
Habitual abortion
Threatened premature delivery
HOW ASTANOL TABLET WORKS
ASTANOL TABLET works by promoting the attachment of embryo to the lining of the womb which also improves blood flow to the placenta thus relaxing the uterus muscles and preventing the occurrence of premature labor in affected women.
DIRECTIONS FOR USE
Take ASTANOL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition
SIDE EFFECTS OF ASTANOL TABLET
COMMON
Nausea
Vomiting
Stomach discomfort
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take this medicine with or after meals. Stick to simple meals while taking this medicine. Do not take any medication on your own. Ask for your doctor’s advice if the nausea doesn’t improve.
Vomiting:
Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, oily, or sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting doesn’t improve.
WARNING & PRECAUTIONS
PREGNANCY
ASTANOL TABLET is generally recommended for use in pregnant women and should be discontinued after delivery. Consult your doctor before taking it.
BREASTFEEDING
ASTANOL TABLET should be used with caution in breastfeeding women as it may affect the child. Consult your doctor before taking it.
KIDNEY
ASTANOL TABLET should be used with caution in patients with kidney diseases such as renal dysfunction. Consult your doctor before taking.
LIVER
ASTANOL TABLET is not recommended in patients with severe hepatic impairment. Consult your doctor before taking it.
ALLERGY
Do not take ASTANOL TABLET if you are allergic to Allylestrenol or any of the other ingredients of this medicine.
LUNGS
ASTANOL TABLET should be used with caution in patients with lung diseases such as asthma, emphysema, chronic bronchitis or chronic obstructive pulmonary disease. Consult your doctor before taking.
HEART DISEASE
ASTANOL TABLET should be used with caution in patients with heart diseases such as congestive heart failure, sick sinus syndrome, and coronary artery disease. Consult your doctor before taking.
OTHERS
ASTANOL TABLET is not recommended for use if you:
Have thrombophlebitis (blood clot in vein)
Have undiagnosed vaginal bleeding
Have incomplete abortion
Have hormone-dependent carcinoma
Have stroke
Plan it as a diagnostic test for pregnancy
Before taking ASTANOL TABLET, inform your doctor if you:
Have migraine headaches
Suffer from seizures (epilepsy)
Use in Pediatrics:
ASTANOL TABLET is not recommended for use in children and adolescents (below the age of 16 years). Consult your doctor before taking.
Use in Geriatrics:
There is no information on the use of ASTANOL TABLET in elderly patients. Consult with your doctor before taking.
INTERACTIONS
A. Drug – Drug interactions:
Before taking ASTANOL TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription or any herbal medicine.
Over dosage:
If you or anyone else accidentally take too much of ASTANOL TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include unusual drowsiness, rapid pulse, fainting, unusual muscle movement or rigidity of the face, neck or limbs, seizures and loss of consciousness.
SYNOPSIS
Drug : Allylestrenol
Pharmacological Category : Progestogen
Therapeutic Indication : Threatened abortion, Habitual abortion, Intrauterine growth retardation (IUGR), Threatened premature delivery
Dosage Forms : Tablet
MORE INFORMATION
Keep ASTANOL TABLET out of reach of children
Store ASTANOL TABLET at room temperature below 25°C
FAQs ABOUT ASTANOL TABLET
Can ASTANOL TABLET be taken if a patient suffers from respiratory disorders?
ASTANOL TABLET should be used with caution in such patients specially, if a patient suffers from breathing disorders such as asthma, emphysema (shortness of breath), chronic bronchitis (inflammation and irritation of bronchial tube) or chronic obstructive pulmonary disease. Consult your doctor before taking ASTANOL TABLET.
Does ASTANOL TABLET cause a disturbed stomach?
Yes, ASTANOL TABLET may cause stomach discomfort as it is a common side effect associated with the use of medicine. You can take ASTANOL TABLET with or after meals to minimize the side effect. Also, stick to simple meals, drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, oily, or sweet foods. Avoid carbonated drinks. Do not consume alcohol and consult doctor if the symptom worsens.
Can ASTANOL TABLET be taken by a pregnant or breastfeeding woman?
ASTANOL TABLET is specifically made to be taken during pregnancy but with your doctor’s consent. It should be discontinued after delivery and should be used with caution in breastfeeding women as it may affect the child. Consult with your doctor before taking.
Can I stop taking ASTANOL TABLET on my own?
No. Do not stop taking ASTANOL TABLET until and unless your doctor asks you to. It is suggested to maintain a regular dosing schedule. This will ensure that you remember taking your medicine. Ask for your doctor’s advice if you wish to discontinue taking ASTANOL TABLET.
How to manage if I miss a dose of ASTANOL TABLET?
In case of a missed dose, take ASTANOL TABLET as soon as you remember. You should not take a double dose to make up for the missed dose. Ask for your doctor’s advice.
REFERENCES
1. K.D. Tripathi. Estrogens, Progestins and Contraceptives. Essentials of Medical Pharmacology. Eighth edition. Revised 2019. Page 343.
2. Allylestrenol. NIH National Library of Medicine. National Center for Biotechnology Information. Pubchem. [Revised in April 2022] [Accessed on 30th April 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Allylestrenol#section=Mechanism-of-Action
3. Malhotra, Narendra & Garg, Ruchika & Malhotra, Neharika & Malhotra, Jaideep. Oral Allylestrenol: A Pregnancy-supporting Progestogen. Research Gate. December 2017. [Accessed on 30th April 2022]. https://www.researchgate.net/publication/322739835_Oral_Allylestrenol_A_Pregnancy-supporting_Progestogen
4. N.E.Borglin. G.Eliasson. Analysis of the Pregnancy-Maintaining Effect of Allylestrenol in Threatened and Habitual Abortion. Science Direct. May 2016. [Accessed 30th April 2022] https://www.sciencedirect.com/science/article/pii/S0015028216346234
5. Square Pharmaceuticals Ltd. Geston (Allylestrenol). [Accessed 30th April 2022] http://www.squarepharma.com.bd/downloads/Geston.pdf
6. Leeford Healthcare. Fetogard (Allylestrenol). [Accessed 30th April 2022]. https://www.leeford.in/product/1506/fetogard
USEFUL DIAGNOSTIC TESTS
X-ray
CT scan
Ultrasound
Country Of Origin
India
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