AMNURING 25mg Tablet 10’s

INTRODUCTION

AMNURING 25MG TABLET is a combination of Amitriptyline and Methylcobalamin, which belong to a group of medicines called Tricyclic antidepressants and Vitamins, respectively. It is used in the management of neuropathic pain which is a type of pain caused by damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body which is generally characterized by symptoms such as spontaneous pain which may be of shooting, burning, stabbing or electric shock-like pain, with tingling and numbness feeling.

Avoid taking AMNURING 25MG TABLET if you are allergic to Amitriptyline and Methylcobalamin or have a history of urinary retention due to enlargement of the prostate gland (benign prostatic hypertrophy), myocardial infarction (heart attack), congestive heart failure and/or impaired liver function.

Before taking AMNURING 25MG TABLET, inform your doctor if you have a history of seizures, blood dyscrasias, urinary retention, narrow-angle glaucoma (an eye disorder), increased intraocular (eye) pressure, an overactive thyroid, suicidal thoughts or kidney problems.

AMNURING 25MG TABLET is not recommended for use during pregnancy and in breastfeeding women; it is also not recommended for use in children and adolescents (below 18 years). The most common symptoms of taking AMNURING 25MG TABLET are sleepiness, drowsiness, shakiness of hands or other body parts, dizziness, headache, dry mouth and constipation. Consult your doctor if any of your symptoms get worse.

USES OF AMNURING 25MG TABLET
Management of neuropathic pain
HOW AMNURING 25MG TABLET WORKS

AMNURING 25MG TABLET helps to manage neuropathic pain, where amitriptyline increases the levels of certain chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain and methylcobalamin helps in the production of myelin, a substance that protects the nerve fibres and rejuvenates damaged nerve cells, which together acting with amitriptyline provides relief from neuropathic pain due to damaged nerves.

DIRECTIONS FOR USE

Take AMNURING 25MG TABLET as advised by your physician. Swallow AMNURING 25MG TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF AMNURING 25MG TABLET
COMMON
Sleepiness
Drowsiness
Shakiness of hands or other body parts
Dizziness
Headache
Irregular, hard or rapid heartbeat
Dizziness due to low blood pressure (orthostatic hypotension)
Dry mouth
Constipation
Nausea
Excessive sweating
Weight gain
Slurred or slow speech
Aggression
Problem with the ability of the eye to change its focus from distant to near objects (and vice versa)
Congested nose
Confusion
Sexual disturbances (decreased sex drive, problems with erection)
Disturbance in attention
Changes in taste
Numbness or tingling sensation in the arms or legs
Disturbed coordination
Dilated pupils
Heart block
Weakness
Agitation
Urination disorders such as incontinence, kidney stones and kidney failure
Feeling thirsty
UNCOMMON
Excitement, anxiety, difficulty sleeping, nightmares
Convulsions (fits)
Tinnitus (ringing or buzzing noise in ears)
Increased blood pressure
Diarrhea
Vomiting
Skin rash, nettle rash, swelling of the face and tongue
Difficulties passing urine
Increased production of breast milk or breast milk outflow without breastfeeding
Increased pressure in the eyeball
Collapse conditions
Worsening of cardiac failure
Liver function impairment such as cholestatic liver disease
RARE
Decreased appetite
Delirium (especially in elderly patients)
Hallucinations
Abnormality in the heart’s rhythm or heartbeat pattern
Swelling of the salivary glands
Hair loss
Increased sensitivity to sunlight
Breast enlargement in men
Fever
Weight loss

Stop taking AMNURING 25MG TABLET and contact your doctor if you experience any of the following side effects:

Signs of acute glaucoma (serious eye condition) such as attacks of intermittent blurring of vision, rainbow vision and eye pain
Signs of prolonged qt interval such as fast, chaotic heartbeats
Signs of the paralyzed intestine such as bad constipation, a swollen stomach, fever and vomiting
Signs of jaundice such as yellowing of the skin and the white in the eyes
Signs of blood or bone marrow effects such as bruising, bleeding, pallor or persistent sore throat and fever
Suicidal thoughts or behaviour
HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest, relax and get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult and inform your doctor if the symptom does not improve.

Headache:

If AMNURING 25MG TABLET causes a headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Paracetamol is safe to be taken with these medicines. Headaches should usually go away after the first week of taking AMNURING 25MG TABLET. If headaches last more than a week or are severe, inform your doctor.

Nausea and vomiting:

Try to take AMNURING 25MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fiber foods, such as fresh fruit, vegetables and cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor about receiving alternate treatments for constipation.

Diarrhea:

Drink lots of fluids, such as water, to keep yourself hydrated. Try to avoid taking any medicine to treat diarrhoea. Consult your doctor if the symptom worsens.

WARNING & PRECAUTIONS
PREGNANCY

AMNURING 25MG TABLET is not recommended for use during pregnancy or in women with childbearing potential. Consult your doctor before taking AMNURING 25MG TABLET.

BREASTFEEDING

AMNURING 25MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking AMNURING 25MG TABLET.

DRIVING AND USING MACHINES

AMNURING 25MG TABLET might cause dizziness or drowsiness. If you experience these side effects, try to avoid driving or operating heavy machines. Consult your doctor before taking AMNURING 25MG TABLET.

ALCOHOL

Avoid consumption of alcohol while taking AMNURING 25MG TABLET since it increases the sedative effect.

KIDNEY

AMNURING 25MG TABLET should be used with caution in patients with kidney problems such as renal failure. Consult your doctor before taking AMNURING 25MG TABLET.

LIVER

AMNURING 25MG TABLET is not recommended for use in patients with impaired liver function. Consult your doctor before taking AMNURING 25MG TABLET.

ALLERGY

AMNURING 25MG TABLET is not recommended for use if you are allergic to Amitriptyline, Methylcobalamin or any other ingredients of this medicine.

HEART DISEASE

AMNURING 25MG TABLET is not recommended for use if you have heart diseases such as myocardial infarction (heart attack) and congestive heart failure. Consult your doctor before taking AMNURING 25MG TABLET.

OTHERS

AMNURING 25MG TABLET is not recommended for use if you:

Have a history of urinary retention due to enlargement of the prostate gland (benign prostatic hypertrophy)

Before taking AMNURING 25MG TABLET, inform your doctor if you:                                                                   

Have a history of seizures
Have  a history of blood dyscrasias
Have a history of urinary retention
Have a history of narrow-angle glaucoma
Have a history of increased intraocular pressure
Have hyperthyroidism
Have suicidal thoughts

Use in Pediatrics:

AMNURING 25MG TABLET should be used with caution in children and adolescents (below 18 years). Consult your doctor before taking AMNURING 25MG TABLET.

Use in Geriatrics:

AMNURING 25MG TABLET should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking AMNURING 25MG TABLET.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking AMNURING 25MG TABLET, inform your doctor, if you are taking any of the following medicine:

Guanethidine (a medicine used to treat hypertension)
Anticholinergic agents (a medicine used to treat overactive bladder) Ex. atropine, belladonna alkaloids, benztropine mesylate
Sympathomimetic drugs (medicines used to treat glaucoma, anaphylactic shock, chronic obstructive pulmonary disease) Ex. benzphetamine, ritodrine
Cimetidine (a medicine used to treat ulcers)
Ethchlorvynol (a medicine used to treat insomnia)
Barbiturates (a medicine used to treat seizures)
Neomycin (a medicine used to prevent or treat bacterial skin infections)
Aminosalicylic acid (a medicine used for tuberculosis)
H2- blockers (a medicine used for gastric ulcers) Ex. famotidine, nizatidine and ranitidine
Colchicine (a medicine used to treat inflammation and pain)
Oral contraceptives (a medicine used for birth control) such as sprintec, taytulla
Parenteral chloramphenicol (a medicine used for superficial eye infections)

Overdosage:

If you or anyone else accidentally takes too much of AMNURING 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are temporary confusion, disturbed concentration or transient visual hallucinations, hypothermia (a dangerous drop in temperature), drowsiness,  fast heart rate, bundle branch block, congestive heart failure, dilated pupils, disorders of ocular motility (eye movement), convulsions, severe low blood pressure,  stupor (state of unconsciousness), coma, polyradiculoneuropathy (autoimmune disorder); constipation, agitation, muscle rigidity, overactive reflexes, high fever and vomiting.

SYNOPSIS
Drug :   Amitriptyline, Methylcobalamin
Pharmacological Category :   Tricyclic antidepressants and Vitamins
Therapeutic Indication :   Neuropathic pain
Dosage Forms :   Tablet
MORE INFORMATION
Keep the medicine out of reach from children
Store AMNURING 25MG TABLET at room temperature
FAQs ABOUT AMNURING 25MG TABLET

Q: What is the function of AMNURING 25MG TABLET?

AMNURING 25MG TABLET is used in the management of neuropathic pain, which is a type of pain caused by damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body.

Q: Who should avoid taking AMNURING 25MG TABLET?

A: AMNURING 25MG TABLET is not recommended for use in patients who are allergic to Amitriptyline and Methylcobalamin, have a history of urinary retention due to enlargement of the prostate gland (benign prostatic hypertrophy), myocardial infarction (heart attack), congestive heart failure, impaired liver function or are pregnant or breastfeeding women.

Q: What side effects are seen with AMNURING 25MG TABLET?

A: The most common symptoms of taking AMNURING 25MG TABLET are sleepiness, drowsiness, shakiness of hands or other body parts, dizziness, headache, dry mouth and constipation. Consult your doctor if any of these symptoms get worse.

Q: Is it safe to drive after taking AMNURING 25MG TABLET?

A: AMNURING 25MG TABLET might cause dizziness or drowsiness. If you experience these side effects, try to avoid driving or operating heavy machines. Consult your doctor before taking AMNURING 25MG TABLET.

Q: What happens if you take more AMNURING 25MG TABLET than your required dose?

A: If you or anyone else accidentally takes too much AMNURING 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are temporary confusion, disturbed concentration, visual hallucinations, hypothermia (a dangerous drop in temperature), drowsiness, a fast heart rate, congestive heart failure, dilated pupils, convulsions, severe low blood pressure, stupor (state of unconsciousness), coma, constipation, agitation, muscle rigidity, overactive reflexes, a high fever and vomiting.

REFERENCES

1. KD Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs & Haematinics and Erythropoietin. Essentials of medical pharmacology. Seventh edition. 2013. Page – 464 & 608.

2. EpiCept Corporation.A Study of the Efficacy and Safety of Amitriptyline/Ketamine Topical Cream in Patients With Diabetic Peripheral Neuropathy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in May 2011] [Accessed on 7th June 2022] https://clinicaltrials.gov/ct2/show/NCT00476151

3. Clair Haslam and Turo Nurmikk. Pharmacological treatment of neuropathic pain in older persons. NIH National Library of Medicine, National center for biotechnology information. PMC PubMed Central. March 2008. [Accessed on 7th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544357/

4. Brown & Burk UK Ltd. Electronic medicines compendium (EMC). [Revised in January 2022] [Accessed on 7th June 2022] https://www.medicines.org.uk/emc/files/pil.10850.pdf

5. The madras pharmaceuticals. Am Nursing Tablets. [Revised in January 2022] [Accessed on 7th June 2022] https://www.centaurpharma.com/downloads/2022/neurology/Am-Nuring.pdf

USEFUL DIAGNOSTIC TESTS
Cryoglobulins
Cerebrospinal fluid analysis
Net Qty
1 N
Item Weight
17.5 g
Ingredient
AMITRIPTYLINE 25MG+METHYLCOBALAMIN 1500 MCG
Hsn Code
30049082
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