INTRODUCTION
ALRISTA SR contains Epalrestat which belongs to the group of medicines called Aldose reductase inhibitors. It is used in the treatment of diabetic neuropathy. Diabetic neuropathy is a serious and common complication of type 1 and type 2 diabetes, which is a type of nerve damage that occurs due to long-term high blood sugar levels in diabetic patients that affects most often the legs and feet. It is generally characterized by symptoms such as numbness/reduced ability to feel pain or temperature changes, tingling/burning sensation, sharp pains/cramps, and muscle weakness.
Epalrestat works by inhibiting an enzyme (aldose reductase) which converts glucose into sorbitol. In diabetics, there is an excess sorbitol production that gets deposited in nerves and other tissues, causing diabetic neuropathy. By inhibiting the enzyme, epalrestat delays sorbitol accumulation in nerves and other tissues thus delaying the progression and occurrence of diabetic neuropathy in affected individuals. During treatment with ALRISTA SR, your doctor will closely monitor you if you have diabetic peripheral neuropathy with irreversible organic changes.
ALRISTA SR is not recommended for use in patients with allergic to Epalrestat. It should be used with caution in patients with diabetic peripheral neuropathy with irreversible organic changes. ALRISTA SR should be used with caution in pregnant women only if it is clearly advised by your doctor. It should be used with caution in breastfeeding women after consulting the doctor.
The safety and effectiveness of ALRISTA SR have not been established in children and adolescents (under 18 years of age), so consult your doctor before taking it. The most common side effects of taking ALRISTA SR are elevated liver enzymes (signs are dark urine, tiredness, itching, jaundice, and loss of appetite), and/or gastrointestinal disorders such as nausea, vomiting. Contact your doctor if any of these symptoms worsen.
USES OF ALRISTA SR
To treat diabetic neuropathy
HOW ALRISTA SR WORKS
ALRISTA SR works by inhibiting an enzyme (aldose reductase) which converts glucose into sorbitol. In diabetics, there is excess production of sorbitol that gets deposited in nerves and other tissues, causing diabetic neuropathy. Thus, by inhibiting the enzyme, ALRISTA SR delays sorbitol accumulation in nerves and other tissues thereby delaying the progression and occurrence of diabetic neuropathy in affected individuals.
DIRECTIONS FOR USE
Take ALRISTA SR as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ALRISTA SR
COMMON
Signs of elevated liver enzymes such as dark urine, tiredness, itching, jaundice (yellowing of your skin or eyes), and loss of appetite
Gastrointestinal disorders such as nausea, vomiting
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take ALRISTA SR with, or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. If nausea does not improve, contact your doctor.
Vomiting:
Get adequate rest. Drink lot of fluids, especially water. Have small sips if you feel sick. Do not lie down immediately after eating. Do not take any medicine for vomiting without asking your doctor. If vomiting does not improve, contact your doctor.
WARNING & PRECAUTIONS
PREGNANCY
ALRISTA SR should be used with caution in pregnant women only if it is considered clearly necessary. Consult your doctor before taking it.
BREASTFEEDING
ALRISTA SR should be used with caution in breastfeeding women. Consult your doctor before taking it.
KIDNEY
ALRISTA SR should be used with caution in patients with kidney problems such as renal impairment. Consult your doctor before taking ALRISTA SR.
ALLERGY
Do not take ALRISTA SR if you are allergic to Epalrestat or any of the other ingredients of this medicine.
OTHERS
Before taking ALRISTA SR, inform your doctor if you:
Have diabetic peripheral neuropathy with irreversible organic changes
Use in pediatrics:
The safety and effectiveness of ALRISTA SR have not been established in children and adolescents (under 18 years of age). Consult child’s doctor for advice.
Use in geriatrics:
ALRISTA SR should be used with caution in elderly patients (aged above 70 years). Consult your doctor before taking ALRISTA SR.
INTERACTIONS
Overdosage:
If you or anyone else accidentally take too much of ALRISTA SR, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
Drug : Epalrestat
Pharmacological Category : Aldose reductase inhibitor
Therapeutic Indication : Diabetic neuropathy
Dosage Forms : Tablet
MORE INFORMATION
Keep ALRISTA SR out of reach of children
Store at room temperature
FAQs ABOUT ALRISTA SR
Can ALRISTA SR be used in children?
As, safety and effectiveness of ALRISTA SR have not been established in children and adolescents (under 18 years of age). Consult child’s doctor for advice. Your doctor will decide the correct dose or select a suitable alternative therapy for your child.
Can ALRISTA SR cause vomiting?
Vomiting is a common side effect associated with the use of ALRISTA SR. To manage this effect, get adequate rest and drink lot of fluids, especially water. Have small sips if you feel sick. Do not lie down immediately after eating. Do not take any medicine for vomiting without asking your doctor. Tell your doctor if you have continuous vomiting.
What precautions do I need to follow while taking ALRISTA SR?
Patients taking ALRISTA SR must inform their doctor about their pre-existing conditions like kidney, liver, or heart problems. Patients should also inform if they are pregnant, breast-feeding, or having any allergies. Consult your doctor if you experience any unusual effects.
Can ALRISTA SR be used during pregnancy?
ALRISTA SR should be used with caution during pregnancy only if it is clearly advised by your doctor. If you think you are pregnant, or planning to get pregnant, consult your doctor before taking this medicine. Inform your doctor immediately if you become pregnant during treatment with ALRISTA SR.
Can I take other medicines with ALRISTA SR?
Before taking ALRISTA SR, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription or any herbal medicine, as these might interact with each other and alter the effect of the medicine.
How does ALRISTA SR work?
ALRISTA SR works by inhibiting an enzyme (aldose reductase) which converts glucose into sorbitol. In diabetics, there is an excess sorbitol production that gets deposited in nerves and other tissues, causing diabetic neuropathy. By inhibiting the enzyme, epalrestat delays sorbitol accumulation in nerves and other tissues thus delaying the progression and occurrence of diabetic neuropathy in affected individuals.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 279.
2. S.R Sharma, Nalini Sharma. Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: an Indian perspective. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. December 2008. [Accessed on 7th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771994/
3. J W Steele, D Faulds, K L Goa. Epalrestat. A review of its pharmacology, and therapeutic potential in late-onset complications of diabetes mellitus. NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. November 2013. [Accessed on 7th July 2022] https://pubmed.ncbi.nlm.nih.gov/8312678/
4. Mary Ann Ramirez, Nancy L Borja. Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy. NIH. National Library of Medicine. National center for biotechnology information. PubMed.gov. May 2008. [Accessed on 7th July 2022] https://pubmed.ncbi.nlm.nih.gov/18447661/
5. Aaron I. Vinik, Elsa S. Strotmeyer, Abhijeet A Nakave, and Chhaya V Patel. Diabetic Neuropathy in Older Adults. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. August 2009. [Accessed on 7th July 2022] https://pubmed.ncbi.nlm.nih.gov/18447661/
6. Micro Labs Ltd. Eparel 50 Tablets (Epalrestat 50 mg) [Accessed on 7th July 2022] https://www.microlabsltd.com/elibrary/node/1813
USEFUL DIAGNOSTIC TESTS
Filament test
Sensory test
Nerve conduction test
Electromyography
Autonomic test
Net Qty
1 N
Item Weight
17.5 g
Ingredient
EPALRESTAT 150MG (SR)
Hsn Code
30049082
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