Acitrom 1mg Tablet 30’S

INTRODUCTION

ACITROM contains Nicoumalone which belongs to theroup of medicines called Anti-coagulants. It is used to treat or prevent the formation of blood clots in the body. Blood clots (also known as thrombosis) are semi-solid masses of blood cells deposited within the blood vessels. It happens due to excessive clumping of platelets (blood cells) or other blood proteins within the blood vessels. As a result, it blocks them and reduce blood flow within them, leading to various complications such as deep vein thrombosis (blood clot in veins of legs), pulmonary embolism (blood clot in veins of lungs), heart attack, abnormal heart rate or stroke. ACITROM can also be used as an adjunct in the treatment of coronary occlusion (block in heart which reduces oxygen and blood supply leading to heart attack) and transient cerebral ischemic attacks (mini stroke, caused by blockage in the blood vessel supplying the brain).

Nicoumalone is a blood thinning medication. It works by preventing the formation of blood clots within the blood vessels. It blocks the actions of certain blood proteins and enzymes that forms blood clots in the body. As a result, it reduces the risk of heart attack and other serious complications such as stroke, deep vein thrombosis or pulmonary embolism. ACITROM cannot not dissolve an existing blood clot, but it can prevent them fromrowing larger. During treatment with ACITROM, your doctor would regularly monitor your blood clotting time to avoid the risk of unwanted side effects.

Before taking ACITROM inform your doctor if you have any liver, kidney, or heart problems. Avoid drinking alcohol or cranberry juice while taking ACITROM. Inform your doctor if you are scheduled for any upcoming surgeries or if you had met with any accident recently. ACITROM isenerally not recommended for use in pregnant women due to increased risk of bleeding at the time of childbirth. It should be used with caution in children and in elderly patients. The most common side effect of ACITROM is increased bleeding tendency (even after minor cuts or wounds). Consult your doctor if your bleeding becomes uncontrollable.

USES OF ACITROM
Treats or prevents the formation of blood clots
HOW ACITROM WORKS

ACITROM is a blood thinning medication. It works by preventing the formation of blood clots within the blood vessels. It blocks the actions of certain blood proteins and enzymes (such as vitamin k reductase, prothrombin, coagulation factors VII, IX, X and protein C) that forms blood clots in the body. As a result, it improves blood flow and oxygen supply through the blood vessels and reduce the symptoms of blood clotting disorders such as deep vein thrombosis, pulmonary embolism, heart attack, abnormal heart rate or stroke.

DIRECTIONS FOR USE

Take ACITROM as advised by your physician. Swallow the medicine with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ACITROM
COMMON
Bleedingums
Heavy menstrual bleeding
Unexplained bruising or nosebleeds
Severe bleeding from minor cuts or wounds
RARE
Loss of appetite
Vomiting, nausea
Hair loss

Stop taking ACITROM and contact your doctor immediately if you experience any of the following side effects:

Signs of bleeding in the stomach (abdominal pain, vomiting blood, bloody or black tarry stools)
Signs of bleeding in the urinary tract (backache, blood in urine)
Signs of bleeding in the brain (dizziness, severe headache, weakness in one arm or leg)
Signs of bleeding in the eyes (such as eye redness)
Allergic reaction (such as skin rash, itching, inflammation with fever)
HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily and spicy food.

Loss of appetite:

Eat when you are hungry. Try to eat smaller meals more often than usual. Snack only when you’re hungry. Always try to have a nutritious snack that is high in calories and protein, such as dried fruit and nuts.

WARNING & PRECAUTIONS
PREGNANCY

ACITROM is not recommended for use in pregnant women, as it may cause serious harm to therowing foetus. Consult your doctor for advice before taking. Women of childbearing potential should use suitable contraceptive method to avoidetting pregnant.

BREASTFEEDING

ACITROM is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor for advice before taking.

DRIVING AND USING MACHINES

ACITROM does not affect your ability to drive or operate heavy tools or machines.

ALCOHOL

Avoid consumption of alcohol while taking ACITROM, as it may lead to unwanted side effects.

KIDNEY

ACITROM is not recommended for use in patients having severe kidney diseases. It should be used with caution in patients having other kidney problems. Therefore, consult your doctor for advice before taking.

LIVER

ACITROM is not recommended for use in patients having severe liver diseases. It should be used with caution in patients having other liver problems. Therefore, consult your doctor for advice before taking.

ALLERGY

Do not take ACITROM if you are allergic to Nicoumalone, warfarin, or phenprocoumon, etc.

HEART DISEASE

ACITROM is not recommended for use in patients having severe high blood pressure. It should be used with caution in patients having heart failure. Therefore, consult your doctor for advice before taking.

OTHERS

ACITROM is not recommended for use if you:

Have any mental illness such as schizophrenia or dementia
Have a habit of drinking excessive alcohol (alcohol abuse)
Have recently had or areoing to have any major surgery on your spine, brain or eyes
Have stroke caused due to brain haemorrhage (bleeding in the brain)
Have stomach ulcer or bleeding from intestines
Have blood in urine or in vomit
Have any forms of bleeding disorders or unexplained bruising
Areoing to receive any injections in your muscles

Before taking ACITROM, inform your doctor if you:

Have cancer
Have any signs of infection or inflammation in the body
Have overactive thyroid
Have ever had any stomach or intestinal ulcer
Have any recent wound or injury
Need any injections into spine or as part of a scan, x-ray or any dental surgeries
Have anaemia (low RBC count in the blood)
Had recently met with an accident

Use in pediatrics:

ACITROM should be used in caution in children and adolescents below (18 years). Consult your doctor for advice before taking.

Use ineriatrics:

ACITROM should be used with caution in elderly patients (aged above 65 years). Proper dose adjustments are required in such patients. Therefore, consult your doctor for advice before taking.
INTERACTIONS

A. Drug – Drug interactions:

Other medicines used to prevent blood clots (Ex. heparin, dipyridamole, clopidogrel, ticlopidine, ateplase or reteplase)
Medicines used to treat bacterial infections (Ex. clindamycin, clarithromycin, tetracyclines, neomycin, chloramphenicol, amoxicillin, sulfasalazine, clavulanic acid, cephalosporins, ciprofloxacin, norfloxacin and ofloxacin)
Medicines used to treat anxiety or depression (Ex. viloxazine, citalopram, fluoxetine, sertraline, paroxetine, or St. John’s Wort)
Rifampicin (used to treat tuberculosis)
Medicines used to treat pain or fever (Ex. aspirin, paracetamol, tramadol, phenylbutazone, celecoxib)
Allopurinol or sulfinpyrazone (used to treatout)
Immunosuppressants (medicines used to suppress immune function) Ex. methylprednisolone or prednisolone
Anabolic steroids (medicines used to treat hormonal disorders). Ex nandrolone, oxandrolone
Medicines used to treat irregular heartbeat (Ex. amiodarone and quinidine)
Medicines used to treat diabetes (Ex. tolbutamide, chlorpropamide,limepiride)
Thyroid hormones (used to treat thyroid deficiency states) Ex. levothyroxine or dextrothyroxine
Medicines used to treat stomach problems (Ex. cimetidine, ranitidine, omeprazole, cisapride)
Medicines used to control blood cholesterol levels (Ex. atorvastatin, fluvastatin, simvastatin fenofibrate,emfibrozil, or cholestyramine)
Disulfiram (a medicine used to control alcohol abuse)
Etacrynic acid (a medicine used to treat water retention or high blood pressure)
Glucagon (a medicine used to treat low blood sugar levels)
Medicines used to treat fungal infections (Ex. econazole, miconazole, ketoconazole, fluconazole orriseofulvin)
Metronidazole (a medicine used to treat protozoal infections)
Glucosamine (a medicine used to treat bone problems)
Medicines used to treat cancer (Ex. 5-fluorouracil, azathioprine, aminoglutethimide, mercaptopurine, or tamoxifen)
Medicines used to treat HIV infection (Ex. indinavir, ritonavir, nelfinavir or saquinavir)
Oral contraceptives (birth control pills) Ex. drospirenone, ethinylestradiol
Diuretics (medicines used to increase urine output) Ex. bendroflumethiazide, metolazone 
Medicines used to treat epilepsy (Ex. phenobarbital, phenytoin, carbamazepine)
Supplements containing vitamin E or vitamin K

B. Drug – Food interaction:

Avoid drinking cranberry juice or taking other cranberry products such as capsules or concentrates while taking ACITROM.

Overdosage:

If you or anyone else accidentally took more ACITROM, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include nosebleeds, bleedingums, vomiting, or coughing up blood, bloody urine, bloody and black tarry stools,enital bleeding, excessive mensural bleeding, large bruises, bleeding into the joints causing tightness, swelling and pain, increased heartbeat, decreased blood pressure which can make you feel dizzy and can make you skin pale, cold and sweaty. You may also experience vomiting, diarrhea or stomach pain.

SYNOPSIS
Drug :   Nicoumalone
Pharmacological Category :  

Coumarin Derivatives

Therapeutic Indication :  

Blood clots

Dosage Forms :   Tablet
MORE INFORMATION
Keep ACITROM out of reach of children
Store in room temperature
FAQs ABOUT ACITROM

How to take ACITROM?

Take ACITROM as prescribed by your physician. It can be taken at the same time every day. Swallow ACITROM with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

How ACITROM works on my body?

ACITROM is a blood thinning medication. It works by preventing the formation of blood clots within the blood vessels. It blocks the actions of certain blood proteins and enzymes that causes blood clots in the body. As a result, it improves the blood flow and oxygen supply through the blood vessels of major organs (heart, brain, and lungs) and improve the symptoms of blood clot disorders.

Is ACITROM safe to use during pregnancy?

If you are pregnant or think you may be pregnant consult your doctor before taking ACITROM. ACITROM has a potential to affect therowing baby and so your doctor will decide whether you should use ACITROM or not depending upon your health condition.

Can ACITROM be taken along with alcohol?

No. Avoid consumption of alcohol while taking ACITROM because it may interfere with its actions and may lead to unwanted side effects.

What can I do if I forget to take ACITROM on time?

If you forgot to take ACITROM, take it as soon as you remember. If it’s time for the next dose, skip the missed one and take the next dose on time. Never take a double dose to compensate the missed dose as it could lead to toxicity.

Can I take antibiotics along with ACITROM?

It is always advisable to consult your doctor before taking any medicines along with ACITROM. Studies have shown that the use of antibiotics simultaneously with anticoagulants like nicoumalone, increases the risk of bleeding in patients, and so concomitant use of antibiotics along with ACITROM should be avoided without proper medical supervision.

Why am I not supposed to undergo any surgery while taking ACITROM?

It is because ACITROM increases your tendency to bleed. As surgeries are always associated with increased risk of bleeding, concomitant use of ACITROM with surgeries may make you bleed more than usual. Therefore, it is important to inform your doctor about the use of ACITROM before undergoing any surgeries (including minor surgeries) to avoid the risk of excessive bleeding.

Is ACITROM safe to use in children?

ACITROM should be used with caution in children and adolescents (below 18 years of age). Therefore, consult your doctor for advice before taking.

How long should I take ACITROM?

You should continue to take ACITROM unless your doctor tells you to stop. Failure to complete the suggested course may not help you in treating the condition properly.

What are the side effects caused due to long term use of ACITROM?

ACITROM may increase the risk of bleeding. It may make you bleed more easily even after minor cuts, injuries, or wounds, and therefore patients must be advised not to undergo even minor surgeries. It may also cause heavy menstrual period or internal bleeding which can be reflected as blood in vomiting, bloody urine or stools, bloody eyes, or blurred vision. To avoid this your doctor would periodically measure your blood clotting time during treatment with ACITROM. Therefore, do not miss your regular hospital visits and take this medicine only as advised by your physician. Consult your doctor if you experience any unusual bleeding over a prolonged period.

How long will it take for ACITROM to start working?

It may take around 3-4 days for ACITROM to start working. If immediate blood thinning is necessary, your doctor may prescribe you with other potent anticoagulants (like heparin or warfarin) along with ACITROM during the initial days. Therefore, consult your doctor for advice.

REFERENCES

1. K.D. Tripathi MD. Drugs Affecting Coagulation Bleeding and Thrombosis. Essentials of Medical Pharmacology. Seventh Edition. 2019. Page 620-623.

2. Abhijit Trailokya, JS Hiremath, JPS Sawhney, YK Mishra, Vivek Kanhere R Srinivasa, Mangesh Tiwaskar. Acenocoumarol – A review of anticoagulant efficacy and safety. Journal of Association of Physicians of India [Revised in December 2015]. [Accessed on 6th May 2022] https://www.japi.org/q2e45484/acenocoumarol-a-review-of-anticoagulant-efficacy-and-safety

3. Norgine Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in July 2020] [Accessed on 6th May 2022] https://www.medicines.org.uk/emc/files/pil.2058.pdf

4. Paladin Labs Inc. [Revised on 22nd May 2009]. [Accessed on 6th May 2022] https://www.paladin-labs.com/our_products/Sintrom_en.pdf

5. Abbott Healthcare Pvt Ltd. [Revised in July 2019]. Accessed on 6th May 2022] acitrom.com/api.html

PRODUCT DETAILS
Net Qty
1 N
Item Weight
40
Ingredient
Nicoumalone(Acenocoumarol) 1 MG
Hsn Code
30045010
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