INTRODUCTION

TMC 80MG INJECTION contains Tobramycin which belongs to the group of medicines called Antibiotics. It is used to treat bacterial infections of brain and nervous system (Ex. meningitis which is characterized by fever, headache and neck stiffness), stomach (gastroenteritis which is characterized by nausea (feel sick), vomiting, fever, diarrhea, abdominal cramps and pain), intestines, bladder, kidney (urinary tract infection characterize by pelvic pain, pain while urinating and blood in urine), lungs, airway (pneumonia with symptoms of cough, fever, chills, breathing difficulty) and bone, skin or soft tissue including burns, blood poisoning.

Before receiving this medicine TMC 80MG INJECTION inform your doctor if you have kidney disease or need dialysis, muscle disorder, such as myasthenia gravis, or Parkinson’s disease, are dehydrated, history of mitochondrial mutation disease (caused by variants in the genome of mitochondria, the parts of your cells which help make energy), have extensive burns, loss of hearing, endocarditis (an inflammation inside the heart), neutropenia (a low number of white blood cells).

TMC 80MG INJECTION is not recommended for use in pregnant and breast-feeding woman. Consult your doctor for advice.

TMC 80MG INJECTION should be received with caution in children and elderly patients. The common side effects of receiving TMC 80MG INJECTION are pain at the site of injection. redness, swelling, and tenderness along a vein, change in urine function. Consult your doctor if the symptoms does not improve.

USES OF TMC 80MG INJECTION
Used to treat bacterial infections
HOW TMC 80MG INJECTION WORKS

TMC 80MG INJECTION effectively works against the disease-causing bacteria by binding irreversibly to one of two amino glycoside binding sites on the 30 S ribosomal subunit of bacteria, inhibiting protein synthesis and thereby terminating the bacterial growth.

DIRECTIONS FOR USE

TMC 80MG INJECTION will be administered by your doctor or nurse into intramuscularly or intravenously. Your healthcare provider will administer the right dose depending upon your age, body weight and health condition.

SIDE EFFECTS OF TMC 80MG INJECTION
COMMON
Pain at the site of injection
Redness, swelling, and tenderness along a vein
Change in white cells count in the blood that may result in infections
Passing more urine than usual
UNCOMMON
Headache, cough
Hoarseness of voice or difficulty speaking, sore throat, difficulty in breathing, noisy breathing
Nausea
Rashes or colored spots
Itching
RARE
Confusion and disorientation
Increased sputum secretion or coughing up blood
Diarrhea
Fever
Feeling tired or drowsiness
Palpitations (irregular or fast heartbeat)
Blurred vision
Anemia (reduction in red blood cells which may cause skin pale)

Stop receiving TMC 80MG INJECTION and contact your doctor immediately if you experience any of the following side effects:

Signs of severe allergic reaction such as sudden itchy rash (hives), swelling of the hands, feet, ankles, face, lips, mouth or throat which may cause difficulty in swallowing or breathing, and feeling of fainting
Severe peeling skin (exfoliative dermatitis)
Ringing, buzzing or roaring noise in ears (tinnitus)
Dizziness
Muscle twitching, numbness or pins and needles
Fits or epilepsy
Changes in blood cells with signs of bleeding or bruising (caused by low platelet counts) or more prone to infections (reduced levels of white blood cells), tiredness due to anemia or have sudden fever or sore throat
WARNING & PRECAUTIONS
PREGNANCY

TMC 80MG INJECTION is not recommended for use in pregnant woman or women planning to have a baby unless recommended by the doctor as it can harm the unborn baby. Consult your doctor before receiving TMC 80MG INJECTION.

BREASTFEEDING

TMC 80MG INJECTION is not recommended for use in breastfeeding woman as it passes into the breastmilk. Consult your doctor before receiving TMC 80MG INJECTION.

DRIVING AND USING MACHINES

Do not drive or handle any machines if you feel muscle weakness, while receiving this TMC 80MG INJECTION.

KIDNEY

TMC 80MG INJECTION should be received with caution in patients suffering from kidney diseases or under dialysis. Dose will be adjusted by your doctor. Consult your doctor before receiving TMC 80MG INJECTION.

ALLERGY

Do not receive TMC 80MG INJECTION if you are allergic to Tobramycin or any other ingredients of this medicine.

HEART DISEASE

TMC 80MG INJECTION should be received with caution in patients having endocarditis (an inflammation inside the heart). Consult your doctor before receiving TMC 80MG INJECTION.

OTHERS

Before receiving TMC 80MG INJECTION, inform your doctor if you:

Have a history of mitochondrial mutation disease (condition caused by variants in the genome of mitochondria)
Have a muscle disorder, such as myasthenia gravis
Have Parkinson’s disease
Have severe burns
Ear problems
Neutropenia (a low number of white blood cells)

Use in pediatrics:

TMC 80MG INJECTION should be received with caution in premature, neonatal, infants and children. Your doctor will administer the correct dose and duration depending upon your age and body weight. Consult your doctor before receiving TMC 80MG INJECTION.

Use in geriatrics:

TMC 80MG INJECTION should be used with caution in elderly patients (especially with renal impairment). Dose will be adjusted by your doctor. Consult your doctor before receiving TMC 80MG INJECTION.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving TMC 80MG INJECTION inform your doctor if you are taking any of the following medicine:

Medicines used to treat bacterial infections like cephaloridine, viomycin, polymyxin B, colistin, vancomycin, and cephalosporin antibiotics like cephalothin and aminoglycosides (Ex. amikacin, streptomycin, neomycin, kanamycin, gentamicin, paromomycin)
Amphotericin B (medicine used to treat fungal infection)
Furosemide, bumetanide, mannitol (medicine used to reduce pressure and swelling)
Medicines used as muscle relaxants during general anesthesia (Ex. baclofen, chlorzoxazone)
Cisplatin (medicine used to treat cancer)
Ciclosporin (medicine that reduces the activity of the body’s immune system)
Pyridostigmine and neostigmine (medicines used to treat muscle weakness)
Warfarin and phenindione (medicine used to prevent blood clots)

Overdosage:

TMC 80MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual reactions, contact your doctor immediately.

SYNOPSIS
Drug :   Tobramycin
Pharmacological Category :   Aminoglycosides
Therapeutic Indication :   Bacterial infections
Dosage Forms :   Respule, Eye drops, Eye ointment, Injection
MORE INFORMATION
Keep out of reach of children
Store at room temperature
FAQs ABOUT TMC 80MG INJECTION

What are the uses of TMC 80MG INJECTION?

TMC 80MG INJECTION is used to treat bacterial infections of brain and nervous system, stomach, intestines, bladder, kidney (urinary tract infection), lungs (pneumonia) and bone, skin or soft tissue including burns.

How does TMC 80MG INJECTION work?

TMC 80MG INJECTION effectively works against the disease-causing bacteria by binding irreversibly to one of two amino glycoside binding sites on the 30 S ribosomal subunit of bacteria inhibiting protein synthesis and thereby terminating the bacterial growth.

Can TMC 80MG INJECTION be used in pregnant woman?

TMC 80MG INJECTION is not recommended for use in pregnant or women planning to have a baby unless recommended by the doctor as it can harm the unborn baby. Consult your doctor for advice.

Can TMC 80MG INJECTION be used in children?

Can TMC 80MG INJECTION be used in patients with kidney disease?

TMC 80MG INJECTION should be received with caution in patients suffering from kidney diseases or under dialysis. Dose will be adjusted by your doctor. Consult your doctor for advice.

REFERENCES

1. KD Tripathi MD. Aminoglycosides antibiotics. Essentials of Medical Pharmacology 8th edition. 2019. Page – 793.

2. Wilfried H Nikolaizik, MD, Delia Vietzke, MD, and Felix Ratjen. A pilot study to compare tobramycin 80 mg injectable preparation with 300 mg solution for inhalation in cystic fibrosis patients. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. 2008. [Accessed on 18th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679548/

3. Gizem Reyhanoglu; Anil Kumar Reddy Reddivari. Tobramycin. NIH National Library of Medicine, National center for biotechnology information. StatPearls. 2022 [Revised on June 2022] [Accessed on 18th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK551695/

4. Vianex SA. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 18th July 2022] https://www.medicines.org.uk/emc/files/pil.10194.pdf

5. Fresenius Kabi. U.S Food & Drug Administration. [Revised in October 2013] [Accessed 18th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/065122s008lbl.pdf

6. Pfizer Service Company. Health Products Regulatory Authority (HPRA). [Accessed on 18th July 2022] https://www.hpra.ie/img/uploaded/swedocuments/b22d5303-51a1-411c-96b5-5f42701aadf4.pdf

USEFUL DIAGNOSTIC TESTS
Complete blood count
Kidney function test
PRODUCT DETAILS
Country Of Origin
India

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